Since 2000, Roy Oswalt has pitched the most innings for the Astros, with 1932.1 innings.

	NAME	IP	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Roy Oswalt R. Oswalt	1932.1	303	143	82	.636	291	3.24	1,593	19	7	0	1,865	696	747	167	446	68	5	32	7,976	23	7.42	2.08	3.57	0.78	20.0	5.6	1.20	.298	3.48	76	3.35	77	8.69	217.7
2	Wandy Rodriguez W. Rodriguez	1306.2	227	80	84	.488	218	4.04	1,093	2	2	0	1,295	587	664	147	454	45	1	31	5,577	34	7.53	3.13	2.41	1.01	19.6	8.1	1.34	.299	4.57	98	4.03	96	8.92	28.1
3	Dallas Keuchel D. Keuchel	1189.1	192	76	63	.547	183	3.66	945	12	4	0	1,144	484	521	115	343	21	2	7	4,937	44	7.15	2.60	2.76	0.87	19.1	6.9	1.25	.293	3.94	92	3.71	92	8.66	45.3
4	Framber Valdez F. Valdez	1080.2	188	81	52	.609	166	3.36	1,053	9	3	0	912	404	444	87	389	58	7	1	4,483	61	8.77	3.24	2.71	0.72	23.5	8.7	1.20	.285	3.70	81	3.50	84	7.60	77.8
5	Justin Verlander J. Verlander	810.1	130	73	28	.723	130	2.71	962	3	2	0	589	244	261	106	155	31	0	0	3,166	16	10.68	1.72	6.21	1.18	30.4	4.9	0.92	.253	2.90	65	3.18	76	6.54	92.7
6	Lance McCullers Jr. L. McCullers Jr.	774.0	146	51	37	.580	140	3.70	861	1	0	0	664	318	344	67	335	45	2	4	3,291	48	10.01	3.90	2.57	0.78	26.2	10.2	1.29	.301	4.00	90	3.52	84	7.72	56.8
7	Wade Miller W. Miller	757.2	122	58	38	.604	122	3.79	651	5	1	0	682	319	351	87	301	23	0	14	3,194	18	7.73	3.58	2.16	1.03	20.4	9.4	1.30	.279	4.17	85	4.09	92	8.10	28.4
8	Collin McHugh C. McHugh	753.1	195	58	35	.624	110	3.63	743	1	0	0	699	304	320	82	219	33	26	4	3,145	24	8.88	2.62	3.39	0.98	23.6	7.0	1.22	.298	3.82	90	3.59	88	8.35	42.2
9	Bud Norris B. Norris	689.2	119	34	46	.425	118	4.33	643	0	0	0	687	332	368	85	281	26	0	13	3,001	22	8.39	3.67	2.29	1.11	21.4	9.4	1.40	.306	4.80	110	4.13	104	8.97	-10.9
10	Brad Peacock B. Peacock	542.2	178	32	30	.516	81	4.08	583	0	0	3	477	246	266	77	232	20	35	4	2,316	24	9.67	3.85	2.51	1.28	25.2	10.0	1.31	.285	4.41	101	4.23	103	7.91	-5.2
11	Roger Clemens R. Clemens	539.0	84	38	18	.679	84	2.40	505	1	0	0	409	144	161	33	170	13	0	11	2,167	11	8.43	2.84	2.97	0.55	23.3	7.8	1.07	.260	2.69	56	2.99	68	6.83	84.4
12	Cristian Javier C. Javier	538.0	124	35	21	.625	90	3.66	598	0	0	2	397	219	229	76	219	23	5	1	2,217	23	10.00	3.66	2.73	1.27	27.0	9.9	1.14	.247	3.83	89	4.14	99	6.64	0
13	Hunter Brown H. Brown	531.1	100	36	31	.537	92	3.49	585	1	0	0	461	206	222	61	179	21	1	1	2,186	8	9.91	3.03	3.27	1.03	26.8	8.2	1.20	.299	3.76	85	3.59	87	7.81	31.5
14	Andy Pettitte A. Pettitte	519.2	84	37	26	.587	83	3.38	428	2	1	0	497	195	217	52	142	5	1	11	2,150	8	7.41	2.46	3.01	0.90	19.9	6.6	1.23	.292	3.76	78	3.57	80	8.61	49.3
15	Brett Myers B. Myers	470.1	102	21	26	.447	66	3.77	360	4	0	19	473	197	221	55	129	9	30	9	1,987	10	6.89	2.47	2.79	1.05	18.1	6.5	1.28	.291	4.23	98	3.92	99	9.05	2.2
16	Brandon Backe B. Backe	467.2	108	30	28	.517	79	5.16	318	1	1	0	519	268	275	78	206	14	11	8	2,079	12	6.12	3.96	1.54	1.50	15.3	9.9	1.55	.301	5.29	122	5.30	121	9.99	-47.4
17	Octavio Dotel O. Dotel	449.0	302	22	24	.478	20	3.25	552	0	0	42	344	162	176	51	181	17	109	13	1,869	17	11.06	3.63	3.05	1.02	29.5	9.7	1.17	.274	3.53	71	3.38	75	6.90	53.9
18	Brian Moehler B. Moehler	434.2	125	21	28	.429	66	4.97	242	1	0	1	508	240	253	58	136	9	34	17	1,916	8	5.01	2.82	1.78	1.20	12.6	7.1	1.48	.306	5.24	119	4.74	110	10.52	-20.3
19	Gerrit Cole G. Cole	412.2	65	35	10	.778	65	2.68	602	1	1	0	285	123	134	48	112	10	0	0	1,616	13	13.13	2.44	5.38	1.05	37.3	6.9	0.96	.281	2.92	63	2.66	62	6.22	77.7
20	Tim Redding T. Redding	405.2	91	21	28	.429	72	4.75	290	0	0	0	444	214	245	52	167	15	4	10	1,808	12	6.43	3.71	1.74	1.15	16.0	9.2	1.51	.305	5.44	109	4.60	105	9.85	-9.8
21	José Urquidy J. Urquidy	405.0	79	26	16	.619	70	3.98	326	0	0	1	366	179	181	67	97	12	4	0	1,662	11	7.24	2.16	3.36	1.49	19.6	5.8	1.14	.258	4.02	97	4.51	109	8.13	-16.9
22	Brad Lidge B. Lidge	401.0	378	23	20	.535	1	3.30	561	0	0	123	310	147	160	38	170	26	206	22	1,684	32	12.59	3.82	3.30	0.85	33.3	10.1	1.20	.306	3.59	76	2.98	67	6.96	64.4
23	Shane Reynolds S. Reynolds	387.2	63	24	25	.490	63	4.74	242	3	0	0	438	204	224	57	107	11	0	6	1,682	8	5.62	2.48	2.26	1.32	14.4	6.4	1.41	.301	5.20	103	4.63	103	10.17	-5
24	Chad Qualls C. Qualls	384.2	380	27	22	.551	0	3.51	307	0	0	29	367	150	159	41	98	23	110	17	1,586	7	7.18	2.29	3.13	0.96	19.4	6.2	1.21	.292	3.72	84	3.85	89	8.59	19.5
25	Mike Fiers M. Fiers	384.1	70	21	19	.525	67	4.59	339	1	1	0	389	196	210	68	125	21	0	0	1,647	30	7.94	2.93	2.71	1.59	20.6	7.6	1.34	.293	4.92	112	4.82	114	9.11	-25.8