Between the 2000 and 2009 seasons, Roy Oswalt fanned the most hitters for the Astros, with 1,473 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Roy Oswalt R. Oswalt	1,473	283	137	70	.662	271	3.23	18	6	0	1803.1	1,756	647	695	154	412	66	5	30	7,455	21	7.35	2.06	3.58	0.77	19.8	5.5	1.20	.299	3.47	75	3.34	76	8.76	208.1
2	Wandy Rodriguez W. Rodriguez	660	144	51	52	.495	135	4.33	2	2	0	790.0	796	380	422	93	285	29	1	19	3,389	16	7.52	3.25	2.32	1.06	19.5	8.4	1.37	.303	4.81	101	4.17	95	9.07	20
3	Wade Miller W. Miller	651	122	58	38	.604	122	3.79	5	1	0	757.2	682	319	351	87	301	23	0	14	3,194	18	7.73	3.58	2.16	1.03	20.4	9.4	1.30	.279	4.17	85	4.09	92	8.10	28.4
4	Brad Lidge B. Lidge	561	378	23	20	.535	1	3.30	0	0	123	401.0	310	147	160	38	170	26	206	22	1,684	32	12.59	3.82	3.30	0.85	33.3	10.1	1.20	.306	3.59	76	2.98	67	6.96	64.4
5	Octavio Dotel O. Dotel	552	302	22	24	.478	20	3.25	0	0	42	449.0	344	162	176	51	181	17	109	13	1,869	17	11.06	3.63	3.05	1.02	29.5	9.7	1.17	.274	3.53	71	3.38	75	6.90	53.9
6	Roger Clemens R. Clemens	505	84	38	18	.679	84	2.40	1	0	0	539.0	409	144	161	33	170	13	0	11	2,167	11	8.43	2.84	2.97	0.55	23.3	7.8	1.07	.260	2.69	56	2.99	68	6.83	84.4
7	Andy Pettitte A. Pettitte	428	84	37	26	.587	83	3.38	2	1	0	519.2	497	195	217	52	142	5	1	11	2,150	8	7.41	2.46	3.01	0.90	19.9	6.6	1.23	.292	3.76	78	3.57	80	8.61	49.3
8	Brandon Backe B. Backe	318	108	30	28	.517	79	5.16	1	1	0	467.2	519	268	275	78	206	14	11	8	2,079	12	6.12	3.96	1.54	1.50	15.3	9.9	1.55	.301	5.29	122	5.30	121	9.99	-47.4
9	Billy Wagner B. Wagner	300	240	9	15	.375	0	2.72	0	0	124	251.1	175	76	77	26	83	11	205	10	1,004	20	10.74	2.97	3.61	0.93	29.9	8.3	1.03	.255	2.76	61	3.10	70	6.27	35.9
10	Tim Redding T. Redding	290	91	21	28	.429	72	4.75	0	0	0	405.2	444	214	245	52	167	15	4	10	1,808	12	6.43	3.71	1.74	1.15	16.0	9.2	1.51	.305	5.44	109	4.60	105	9.85	-9.8
11	Shane Reynolds S. Reynolds	242	63	24	25	.490	63	4.74	3	0	0	387.2	438	204	224	57	107	11	0	6	1,682	8	5.62	2.48	2.26	1.32	14.4	6.4	1.41	.301	5.20	103	4.63	103	10.17	-5
12	Chad Qualls C. Qualls	218	262	23	12	.657	0	3.39	0	0	6	284.0	267	107	113	30	84	19	52	14	1,171	3	6.91	2.66	2.60	0.95	18.6	7.2	1.24	.289	3.58	78	4.04	90	8.46	13.3
13	Brian Moehler B. Moehler	214	105	20	24	.455	58	4.98	1	0	1	378.0	442	209	221	53	110	8	29	16	1,667	8	5.10	2.62	1.95	1.26	12.8	6.6	1.46	.303	5.26	119	4.75	109	10.52	-16.4
14	Scott Elarton S. Elarton	207	50	21	15	.583	50	5.66	2	0	0	302.1	324	190	205	55	133	12	0	2	1,354	13	6.16	3.96	1.56	1.64	15.3	9.8	1.51	.284	6.10	121	5.53	120	9.64	-29.4
15	Dan Wheeler D. Wheeler	202	205	6	12	.333	0	3.02	0	0	23	208.2	168	70	72	21	59	8	74	12	843	1	8.71	2.54	3.42	0.91	24.0	7.0	1.09	.266	3.11	69	3.44	77	7.25	23.3
16	Jose Lima J. Lima	165	47	8	18	.308	42	6.79	0	0	0	249.1	328	188	200	60	84	7	3	4	1,144	6	5.96	3.03	1.96	2.17	14.4	7.3	1.65	.324	7.22	143	6.01	128	11.84	-36.1
17	Chris Sampson C. Sampson	160	139	19	15	.559	33	4.28	0	0	3	328.1	347	156	168	33	79	11	17	14	1,378	5	4.39	2.17	2.03	0.90	11.6	5.7	1.30	.287	4.61	100	4.31	97	9.51	4.4
18	Ron Villone R. Villone	156	50	11	13	.458	25	4.69	0	0	0	174.2	168	91	97	28	72	9	6	2	750	3	8.04	3.71	2.17	1.44	20.8	9.6	1.37	.289	5.00	106	4.72	107	8.66	-6
19	Jose Valverde J. Valverde	139	126	10	5	.667	0	2.93	0	0	69	126.0	102	41	43	15	44	4	116	7	522	4	9.93	3.14	3.16	1.07	26.6	8.4	1.16	.272	3.07	70	3.59	83	7.29	10.1
20	Dave Borkowski D. Borkowski	139	130	8	7	.533	0	5.44	0	0	1	178.2	200	108	114	25	71	5	35	21	797	5	7.00	3.58	1.96	1.26	17.4	8.9	1.52	.314	5.74	125	4.71	105	10.07	-3.8
21	Nelson Cruz N. Cruz	136	109	5	9	.357	5	4.31	0	0	2	160.2	162	77	85	23	53	15	27	8	702	4	7.62	2.97	2.57	1.29	19.4	7.5	1.34	.293	4.76	98	4.44	102	9.07	-1.6
22	Carlos Hernandez C. Hernandez	136	35	9	8	.529	33	4.54	0	0	0	170.2	173	86	89	23	91	8	0	5	765	4	7.17	4.80	1.49	1.21	17.8	11.9	1.55	.296	4.69	105	4.88	113	9.12	-10.7
23	Chris Holt C. Holt	136	34	8	16	.333	32	5.35	3	1	0	207.0	247	123	131	22	75	8	1	2	916	10	5.91	3.26	1.81	0.96	14.8	8.2	1.56	.333	5.70	111	4.40	92	10.74	8.2
24	Pete Munro P. Munro	135	80	12	16	.429	35	4.49	0	0	0	234.1	272	117	126	24	75	18	9	7	1,042	5	5.18	2.88	1.80	0.92	13.0	7.2	1.48	.314	4.84	104	4.38	100	10.45	-0.4
25	Ricky Stone R. Stone	130	165	10	8	.556	0	3.80	0	0	2	187.0	188	79	87	26	74	10	46	11	810	3	6.26	3.56	1.76	1.25	16.0	9.1	1.40	.284	4.19	88	4.76	110	9.05	-8.9