Barry Zito had a 126-102 record with an ERA of 3.89 and 1,423 strikeouts in 307 appearances between the 2001 and 2009 seasons.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | B. Zito | 2001 |  OAK | 35 | 17 | 8 | .680 | 35 | 3.49 | 205 | 3 | 2 | 0 | 214.1 | 184 | 83 | 92 | 18 | 80 | 13 | 0 | 0 | 902 | 6 | 8.61 | 3.36 | 2.56 | 0.76 | 22.7 | 8.9 | 1.23 | .283 | 3.86 | 79 | 3.52 | 80 | 7.73 | 21.5 |
| 2 | | B. Zito | 2002 | OAK | 35 | 23 | 5 | .821 | 35 | 2.75 | 182 | 1 | 0 | 0 | 229.1 | 182 | 70 | 79 | 24 | 78 | 9 | 0 | 2 | 939 | 2 | 7.14 | 3.06 | 2.33 | 0.94 | 19.4 | 8.3 | 1.13 | .245 | 3.10 | 63 | 3.86 | 89 | 7.14 | 12.6 |
| 3 | | B. Zito | 2003 | OAK | 35 | 14 | 12 | .538 | 35 | 3.30 | 146 | 4 | 1 | 0 | 231.2 | 186 | 85 | 98 | 19 | 88 | 6 | 0 | 3 | 957 | 4 | 5.67 | 3.42 | 1.66 | 0.74 | 15.3 | 9.2 | 1.18 | .239 | 3.81 | 74 | 4.05 | 90 | 7.23 | 11.8 |
| 4 | | B. Zito | 2004 | OAK | 34 | 11 | 11 | .500 | 34 | 4.48 | 163 | 0 | 0 | 0 | 213.0 | 216 | 106 | 116 | 28 | 81 | 9 | 0 | 2 | 926 | 4 | 6.89 | 3.42 | 2.01 | 1.18 | 17.6 | 8.7 | 1.39 | .291 | 4.90 | 98 | 4.49 | 99 | 9.13 | 0.8 |
| 5 | | B. Zito | 2005 | OAK | 35 | 14 | 13 | .519 | 35 | 3.86 | 171 | 0 | 0 | 0 | 228.1 | 185 | 98 | 106 | 26 | 89 | 13 | 0 | 0 | 953 | 4 | 6.74 | 3.51 | 1.92 | 1.02 | 17.9 | 9.3 | 1.20 | .243 | 4.18 | 92 | 4.33 | 100 | 7.29 | -0.3 |
| 6 | | B. Zito | 2006 | OAK | 34 | 16 | 10 | .615 | 34 | 3.83 | 151 | 0 | 0 | 0 | 221.0 | 211 | 94 | 99 | 27 | 99 | 13 | 0 | 5 | 945 | 4 | 6.15 | 4.03 | 1.53 | 1.10 | 16.0 | 10.5 | 1.40 | .281 | 4.03 | 86 | 4.88 | 108 | 8.59 | -9 |
| 7 |  | B. Zito | 2007 |  SFG | 34 | 11 | 13 | .458 | 33 | 4.53 | 131 | 0 | 0 | 0 | 196.2 | 182 | 99 | 105 | 24 | 83 | 4 | 0 | 4 | 850 | 5 | 5.99 | 3.80 | 1.58 | 1.10 | 15.4 | 9.8 | 1.35 | .260 | 4.81 | 102 | 4.81 | 109 | 8.33 | -9.4 |
| 8 | | B. Zito | 2008 | SFG | 32 | 10 | 17 | .370 | 32 | 5.15 | 120 | 0 | 0 | 0 | 180.0 | 186 | 103 | 115 | 16 | 102 | 4 | 0 | 10 | 818 | 3 | 6.00 | 5.10 | 1.18 | 0.80 | 14.7 | 12.5 | 1.60 | .295 | 5.75 | 120 | 4.71 | 111 | 9.30 | -10 |
| 9 | | B. Zito | 2009 | SFG | 33 | 10 | 13 | .435 | 33 | 4.03 | 154 | 1 | 0 | 0 | 192.0 | 179 | 86 | 89 | 21 | 81 | 8 | 0 | 8 | 818 | 2 | 7.22 | 3.80 | 1.90 | 0.98 | 18.8 | 9.9 | 1.35 | .285 | 4.17 | 98 | 4.30 | 105 | 8.39 | -4.5 |
| Total | 307 | 126 | 102 | .553 | 306 | 3.89 | 1,423 | 9 | 3 | 0 | 1906.1 | 1,711 | 824 | 899 | 203 | 781 | 79 | 0 | 34 | 8,108 | 34 | 6.72 | 3.69 | 1.82 | 0.96 | 17.6 | 9.6 | 1.31 | .268 | 4.24 | 89 | 4.31 | 99 | 8.08 | 13.4 |
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