Rube Waddell has the lowest career ERA by a left-hander, with an ERA of 2.16.

Interpreted as:

best left handed with a minimum of 1500 IP pitchers all-time

	NAME	ERA	IP	G	W	L	W%	GS	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Rube Waddell R. Waddell	2.16	2961.1	407	193	143	.574	340	2,316	261	50	5	2,460	711	1,063	37	803	115	54		11,717	74	7.04	2.44	2.88	0.11	19.8	6.9	1.10	.287	3.23	75	2.03	71	7.48	262
2	Eddie Plank E. Plank	2.35	4495.2	623	326	194	.627	529	2,246	410	69	23	3,958	1,174	1,566	42	1,072	190	77		17,803	88	4.50	2.15	2.10	0.08	12.6	6.0	1.12	.275	3.14	81	2.45	86	7.92	195.2
3	Ed Killian E. Killian	2.38	1598.1	214	103	78	.569	180	516	149	22	4	1,463	423	585	9	482	70	31		6,508	22	2.91	2.71	1.07	0.05	7.9	7.4	1.22	.268	3.29	91	2.80	110	8.24	-41.2
4	Doc White D. White	2.39	3041.0	427	189	156	.548	363	1,384	262	45	5	2,738	808	1,118	33	670	120	53		12,093	63	4.10	1.98	2.07	0.10	11.4	5.5	1.12	.274	3.31	89	2.51	96	8.10	22.9
5	Nap Rucker N. Rucker	2.42	2375.1	336	134	134	.500	274	1,217	186	38	14	2,089	639	823	41	701	73	58		9,441	43	4.61	2.66	1.74	0.16	12.9	7.4	1.17	.276	3.12	86	2.60	90	7.92	73.7
6	Hooks Wiltse H. Wiltse	2.47	2112.1	357	139	90	.607	225	965	152	27	33	1,892	580	787	54	498	40	109		8,413	41	4.11	2.12	1.94	0.23	11.5	5.9	1.13	.268	3.35	89	2.56	90	8.06	70.5
7	Lefty Leifield L. Leifield	2.47	1838.0	296	124	97	.561	216	616	138	32	7	1,673	505	694	27	554	85	57		7,411	17	3.02	2.71	1.11	0.13	8.3	7.5	1.21	.269	3.40	87	2.95	102	8.19	-7.9
8	Hippo Vaughn H. Vaughn	2.49	2730.0	390	178	137	.565	332	1,416	214	41	5	2,461	754	1,039	39	817	85	45		11,225	63	4.67	2.69	1.73	0.13	12.6	7.3	1.20	.273	3.43	83	2.62	88	8.11	108.4
9	Clayton Kershaw C. Kershaw	2.53	2855.1	455	223	96	.699	451	3,052	25	15	0	2,193	804	881	235	713	46	1	28	11,279	108	9.62	2.25	4.28	0.74	27.1	6.3	1.02	.271	2.78	65	2.85	70	6.91	375.1
10	Noodles Hahn N. Hahn	2.55	2029.1	243	130	94	.580	231	917	212	25	0	1,916	574	821	27	381	52	11		8,126	28	4.07	1.69	2.41	0.12	11.3	4.7	1.13	.280	3.64	75	2.65	77	8.50	181.2
11	Slim Sallee S. Sallee	2.56	2821.2	476	174	143	.549	305	836	189	25	36	2,729	804	1,092	68	573	43	123		11,476	12	2.67	1.83	1.46	0.22	7.3	5.0	1.17	.267	3.48	89	2.87	97	8.70	25.8
12	Ed Siever E. Siever	2.60	1507.0	203	83	82	.503	174	470	136	14	2	1,550	435	674	24	311	39	28		6,170	21	2.81	1.86	1.51	0.14	7.6	5.0	1.23	.287	4.03	89	2.82	98	9.26	10.9
13	Carl Weilman C. Weilman	2.67	1521.0	239	84	93	.475	179	536	105	15	10	1,394	451	600	22	418	32	49		5,993	17	3.17	2.47	1.28	0.13	8.9	7.0	1.19	.275	3.55	88	2.85	95	8.25	21.9
14	Nick Altrock N. Altrock	2.67	1514.0	218	83	75	.525	161	425	128	16	7	1,455	449	600	16	272	22	45		6,016	31	2.53	1.62	1.56	0.10	7.1	4.5	1.14	.272	3.57	104	2.56	103	8.65	-22.3
15	Whitey Ford W. Ford	2.75	3170.1	498	236	106	.690	438	1,956	156	45	11	2,766	967	1,107	228	1,086	28	35	44	13,036	75	5.55	3.08	1.80	0.65	15.0	8.3	1.22	.261	3.14	75	3.26	88	7.85	156.9
16	Dutch Leonard D. Leonard	2.76	2192.0	331	139	114	.549	273	1,160	151	33	13	2,022	672	851	54	664	68	47		8,907	61	4.76	2.73	1.75	0.22	13.0	7.5	1.23	.283	3.49	86	2.82	89	8.30	78.4
17	Sandy Koufax S. Koufax	2.76	2324.1	397	165	87	.655	314	2,396	137	40	9	1,754	713	806	204	817	18	44	48	9,497	87	9.28	3.16	2.93	0.79	25.2	8.6	1.11	.256	3.12	75	2.69	75	6.79	226.6
18	Jesse Tannehill J. Tannehill	2.80	2759.1	359	197	117	.627	321	944	264	34	7	2,794	858	1,199	40	478	130	37		11,236	28	3.08	1.56	1.97	0.13	8.4	4.3	1.19	.286	3.91	89	2.86	91	9.11	95.2
19	Ed Morris E. Morris	2.82	2678.0	311	171	122	.584	307	1,217	297	29	1	2,468	838	1,312	42	498	25	4		11,073	112	4.09	1.67	2.44	0.14	11.0	4.5	1.11	.262	4.41	87	2.91	92	8.29	34.1
20	Willie Mitchell W. Mitchell	2.88	1632.0	276	83	92	.474	190	921	93	16	4	1,464	522	731	14	605	75	65		6,692	47	5.08	3.34	1.52	0.08	13.8	9.0	1.27	.286	4.03	97	2.71	91	8.07	54.1
21	Wilbur Cooper W. Cooper	2.89	3480.0	517	216	178	.548	406	1,252	279	35	14	3,415	1,119	1,406	103	853	100	83		14,377	44	3.24	2.21	1.47	0.27	8.7	5.9	1.23	.274	3.64	86	3.17	94	8.83	72.2
22	Harry Brecheen H. Brecheen	2.92	1907.2	318	133	92	.591	240	901	125	25	18	1,731	618	701	116	536	37	53		7,821	18	4.25	2.53	1.68	0.55	11.5	6.9	1.19	.259	3.31	75	3.26	84	8.17	135.3
23	Lefty Tyler L. Tyler	2.95	2230.0	323	127	116	.523	267	1,003	181	30	7	1,990	730	947	51	829	67	45		9,222	55	4.05	3.35	1.21	0.21	10.9	9.0	1.26	.267	3.82	96	3.11	101	8.03	-2.7
24	Carl Hubbell C. Hubbell	2.98	3590.1	535	253	154	.622	433	1,677	260	36	33	3,461	1,188	1,380	227	725	53	82		14,805	53	4.20	1.82	2.31	0.57	11.3	4.9	1.17	.267	3.46	76	3.55	89	8.68	174.2
25	Max Lanier M. Lanier	3.01	1619.1	327	108	82	.568	204	821	91	21	17	1,490	541	630	65	611	18	62		6,772	13	4.56	3.40	1.34	0.36	12.1	9.0	1.30	.271	3.50	79	3.22	84	8.28	108.7