The New York Yankees have the highest run differential by a team this season, with a differential of 112 runs.

Interpreted as:

best point differential in MLB this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	112	2025	84	.571	48	36	2,844	426	717	144	13	128	408	335	35	752	59	20	3,247	1,271	285	4	29	25	55	.252	.335	.447	.782
2	Cubs	104	2025	84	.583	49	35	2,914	453	745	148	17	124	444	288	22	659	100	17	3,256	1,299	289	7	25	9	36	.256	.325	.446	.770
3	Tigers	99	2025	85	.624	53	32	2,874	424	735	138	19	106	408	270	38	736	30	7	3,216	1,229	263	5	29	7	47	.256	.325	.428	.752
4	Dodgers	90	2025	85	.624	53	32	2,910	477	764	146	15	133	459	317	30	694	45	14	3,289	1,339	294	3	29	18	61	.263	.338	.460	.798
5	Rays	69	2025	85	.553	47	38	2,868	407	742	130	9	94	386	258	28	707	109	25	3,185	1,172	233	8	23	4	60	.259	.324	.409	.732
6	Brewers	56	2025	84	.560	47	37	2,811	397	695	121	8	79	368	291	33	674	99	29	3,179	1,069	208	18	26	10	43	.247	.322	.380	.703
7	Phillies	50	2025	85	.588	50	35	2,882	390	733	134	11	89	372	296	33	671	73	15	3,238	1,156	234	8	19	9	53	.254	.329	.401	.730
8	Astros	46	2025	84	.595	50	34	2,802	350	714	117	7	91	333	241	39	649	47	19	3,113	1,118	215	9	22	7	69	.255	.320	.399	.719
9	Mets	39	2025	85	.565	48	37	2,840	368	695	135	13	109	359	294	50	669	64	10	3,215	1,183	257	3	28	14	70	.245	.323	.417	.740
10	Cardinals	38	2025	86	.547	47	39	2,920	403	741	145	4	87	383	269	44	666	47	15	3,267	1,155	236	9	25	12	61	.254	.324	.396	.719
11	Reds	33	2025	85	.518	44	41	2,852	393	706	140	11	92	375	285	27	744	65	23	3,192	1,144	243	6	22	7	54	.248	.320	.401	.721
12	Giants	30	2025	85	.529	45	40	2,777	351	639	125	14	79	332	305	34	713	44	17	3,158	1,029	218	18	24	6	59	.230	.311	.371	.682
13	Red Sox	17	2025	86	.488	42	44	2,965	412	741	163	13	106	393	290	40	795	71	18	3,321	1,248	282	7	19	16	48	.250	.323	.421	.744
14	Mariners	17	2025	84	.524	44	40	2,900	386	720	114	4	110	373	293	47	739	79	22	3,275	1,172	228	14	21	14	55	.248	.325	.404	.729
15	Padres	13	2025	84	.536	45	39	2,795	345	689	126	11	73	321	265	23	589	57	16	3,127	1,056	210	19	25	9	54	.247	.314	.378	.692
16	Braves	12	2025	83	.458	38	45	2,807	339	684	115	8	84	326	293	24	710	42	13	3,151	1,067	207	7	20	9	52	.244	.318	.380	.699
17	Rangers	12	2025	85	.482	41	44	2,816	314	636	115	8	85	301	245	33	698	76	19	3,124	1,022	208	5	25	10	44	.226	.293	.363	.656
18	Diamondbacks	4	2025	84	.500	42	42	2,857	436	727	149	18	122	426	295	39	652	62	19	3,241	1,278	289	15	35	9	55	.254	.329	.447	.776
19	Blue Jays	-3	2025	84	.548	46	38	2,841	370	729	141	4	83	354	277	34	565	44	15	3,195	1,127	228	17	26	15	62	.257	.327	.397	.724
20	Twins	-14	2025	84	.476	40	44	2,818	356	678	132	8	96	343	248	51	694	40	14	3,136	1,114	236	2	17	5	54	.241	.312	.395	.707
21	Pirates	-35	2025	86	.419	36	50	2,852	304	670	115	14	61	294	280	30	748	74	22	3,190	996	190	8	20	12	75	.235	.308	.349	.657
22	Royals	-37	2025	85	.459	39	46	2,843	279	692	141	15	58	275	202	28	584	64	29	3,114	1,037	214	18	23	13	44	.243	.298	.365	.663
23	Guardians	-47	2025	82	.488	40	42	2,667	303	603	114	8	81	288	257	28	679	65	19	2,989	976	203	11	26	12	51	.226	.298	.366	.664
24	Angels	-49	2025	83	.494	41	42	2,770	359	633	112	9	124	345	227	44	808	37	18	3,066	1,135	245	7	18	11	50	.229	.296	.410	.705
25	Nationals	-68	2025	84	.417	35	49	2,818	366	689	142	11	85	350	243	38	634	74	30	3,135	1,108	238	16	20	10	51	.244	.311	.393	.704