The Milwaukee Brewers had the highest run differential by a team this season, with a differential of 172 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Brewers	172	2025	162	.599	97	65	5,510	806	1,423	265	18	166	750	564	73	1,266	164	53	6,223	2,222	449	26	50	15	97	.258	.332	.403	.736
2	Yankees	164	2025	162	.580	94	68	5,471	849	1,371	255	20	274	820	639	55	1,463	134	38	6,226	2,488	549	7	54	47	104	.251	.332	.455	.787
3	Cubs	144	2025	162	.568	92	70	5,495	793	1,371	267	29	223	771	554	46	1,277	161	35	6,160	2,365	519	10	55	16	72	.249	.320	.430	.751
4	Dodgers	142	2025	162	.574	93	69	5,481	825	1,384	257	21	244	791	580	56	1,353	88	25	6,184	2,415	522	13	54	33	108	.253	.327	.441	.768
5	Phillies	130	2025	162	.593	96	66	5,517	778	1,426	268	24	212	753	528	60	1,337	124	30	6,163	2,378	504	16	42	19	95	.258	.328	.431	.759
6	Red Sox	110	2025	162	.549	89	73	5,562	786	1,414	324	24	186	748	518	72	1,419	139	38	6,206	2,344	534	13	41	24	99	.254	.324	.421	.745
7	Padres	81	2025	162	.556	90	72	5,424	702	1,369	254	18	152	663	510	58	1,161	106	30	6,085	2,115	424	48	45	18	103	.252	.321	.390	.711
8	Rangers	79	2025	162	.500	81	81	5,443	684	1,275	245	15	175	658	486	63	1,327	134	33	6,043	2,075	435	11	40	19	92	.234	.302	.381	.684
9	Blue Jays	77	2025	162	.580	94	68	5,507	798	1,461	294	13	191	771	520	65	1,099	77	25	6,172	2,354	498	35	45	25	133	.265	.333	.427	.761
10	Mariners	72	2025	162	.556	90	72	5,502	766	1,345	234	9	238	734	544	89	1,446	161	37	6,197	2,311	481	24	38	29	102	.244	.320	.420	.740
11	Tigers	67	2025	162	.537	87	75	5,456	758	1,346	244	36	198	724	511	65	1,454	61	16	6,087	2,256	478	5	50	12	90	.247	.316	.413	.730
12	Mets	51	2025	162	.512	83	79	5,457	766	1,359	262	19	224	746	563	87	1,325	147	18	6,175	2,331	505	15	53	28	119	.249	.326	.427	.753
13	Reds	35	2025	162	.512	83	79	5,448	716	1,333	250	23	167	677	527	51	1,415	105	30	6,082	2,130	440	12	44	15	106	.245	.315	.391	.706
14	Rays	31	2025	162	.475	77	85	5,470	714	1,374	242	16	182	680	468	46	1,397	194	48	6,043	2,194	440	16	43	10	109	.251	.313	.401	.714
15	Giants	21	2025	162	.500	81	81	5,375	705	1,261	239	28	173	672	556	66	1,380	68	24	6,071	2,075	440	22	52	14	103	.235	.311	.386	.697
16	Astros	21	2025	162	.537	87	75	5,490	686	1,372	247	12	182	655	471	71	1,301	85	28	6,086	2,189	441	16	38	15	124	.250	.315	.399	.714
17	Royals	14	2025	162	.506	82	80	5,431	651	1,342	292	22	159	638	435	69	1,096	111	42	6,005	2,155	473	29	41	19	96	.247	.309	.397	.706
18	Diamondbacks	6	2025	162	.494	80	82	5,480	791	1,377	277	38	214	768	545	81	1,316	121	39	6,207	2,372	529	37	64	21	109	.251	.325	.433	.757
19	Guardians	-6	2025	162	.543	88	74	5,310	643	1,199	243	18	168	621	494	60	1,344	129	34	5,942	1,982	429	28	50	30	78	.226	.296	.373	.670
20	Braves	-10	2025	162	.469	76	86	5,508	724	1,349	243	19	190	701	575	51	1,371	82	25	6,185	2,200	452	15	36	14	98	.245	.320	.399	.720
21	Pirates	-62	2025	162	.438	71	91	5,375	583	1,244	245	21	117	561	530	54	1,422	115	36	6,004	1,882	383	13	32	19	123	.231	.305	.350	.655
22	Cardinals	-65	2025	162	.481	78	84	5,433	689	1,331	264	9	148	653	478	88	1,321	89	27	6,064	2,057	421	25	40	17	115	.245	.314	.379	.693
23	Athletics	-84	2025	162	.469	76	86	5,547	733	1,403	296	16	219	709	502	44	1,406	80	28	6,146	2,388	531	18	35	14	117	.253	.318	.431	.749
24	Marlins	-89	2025	162	.488	79	83	5,543	709	1,388	272	29	154	677	482	54	1,247	138	44	6,142	2,180	455	19	44	13	94	.250	.314	.393	.708
25	White Sox	-95	2025	162	.370	60	102	5,377	647	1,250	243	10	165	626	498	49	1,364	85	21	5,982	2,008	418	22	36	8	108	.232	.302	.373	.675