The New York Yankees had the highest run differential by a team at home in 2022, with a differential of 154 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	154	2022	81	.704	57	24	2,625	419	631	108	3	136	403	310	36	687	49	10	2,997	1,153	247	6	20	23	62	.240	.327	.439	.766
2	Dodgers	144	2022	81	.704	57	24	2,673	422	699	164	17	106	406	280	27	665	48	9	3,002	1,215	287	1	21	8	39	.262	.335	.455	.790
3	Astros	115	2022	81	.679	55	26	2,611	368	672	138	7	116	358	266	24	551	35	12	2,924	1,172	261	5	18	7	54	.257	.330	.449	.778
4	Braves	113	2022	81	.679	55	26	2,656	395	680	137	5	125	378	244	30	754	47	22	2,950	1,202	267	0	20	7	43	.256	.323	.453	.776
5	Mets	110	2022	81	.667	54	27	2,636	376	667	115	13	81	358	267	50	589	34	11	2,990	1,051	209	10	27	16	50	.253	.330	.399	.729
6	Cardinals	109	2022	81	.654	53	28	2,632	392	661	139	8	98	377	270	44	543	46	12	2,976	1,110	245	3	27	6	60	.251	.328	.422	.750
7	Phillies	60	2022	81	.580	47	34	2,689	396	699	131	17	107	385	245	24	668	43	16	2,990	1,185	255	5	27	10	54	.260	.324	.441	.765
8	Rays	57	2022	81	.630	51	30	2,612	336	631	150	8	71	317	244	27	667	43	17	2,908	1,010	229	4	21	6	46	.242	.311	.387	.697
9	Brewers	40	2022	81	.568	46	35	2,647	362	622	127	6	110	350	319	38	743	47	13	3,028	1,091	243	8	16	15	55	.235	.324	.412	.736
10	Giants	31	2022	81	.543	44	37	2,629	363	627	128	10	86	342	297	41	712	31	7	2,998	1,033	224	1	30	4	58	.238	.322	.393	.715
11	Twins	27	2022	81	.568	46	35	2,693	343	687	139	9	89	329	265	26	656	16	6	3,011	1,111	237	5	22	5	57	.255	.325	.413	.738
12	Mariners	19	2022	81	.568	46	35	2,600	318	580	101	8	97	306	284	41	696	41	12	2,954	988	206	8	21	11	55	.223	.307	.380	.687
13	Orioles	8	2022	81	.556	45	36	2,665	343	635	127	9	79	327	237	39	672	37	12	2,970	1,017	215	9	20	8	43	.238	.308	.382	.689
14	Blue Jays	4	2022	81	.580	47	34	2,670	359	696	150	4	102	352	233	32	589	28	14	2,954	1,160	256	4	15	7	67	.261	.326	.434	.760
15	Guardians	3	2022	81	.568	46	35	2,695	325	680	129	13	50	307	238	47	533	56	11	3,014	985	192	12	22	27	63	.252	.321	.365	.687
16	Padres	0	2022	81	.543	44	37	2,628	301	605	105	7	77	290	269	34	666	28	10	2,951	955	189	5	15	12	51	.230	.308	.363	.672
17	Diamondbacks	-7	2022	81	.494	40	41	2,601	353	603	133	10	71	330	267	29	625	44	13	2,944	969	214	18	29	6	51	.232	.307	.373	.680
18	Angels	-9	2022	81	.494	40	41	2,676	330	654	107	18	106	319	229	25	748	30	11	2,957	1,115	231	13	14	14	51	.244	.308	.417	.725
19	Red Sox	-19	2022	81	.531	43	38	2,747	392	747	190	9	86	376	227	31	675	19	9	3,035	1,213	285	3	27	11	64	.272	.331	.442	.773
20	Cubs	-19	2022	81	.457	37	44	2,660	324	661	129	19	73	306	258	39	688	54	14	2,986	1,047	221	8	21	7	62	.248	.322	.394	.715
21	Rockies	-20	2022	81	.506	41	40	2,794	456	790	151	22	98	438	251	30	600	18	12	3,105	1,279	271	5	25	8	72	.283	.345	.458	.803
22	Marlins	-51	2022	81	.420	34	47	2,653	296	625	132	15	71	280	221	42	678	53	15	2,936	1,000	218	0	20	5	53	.236	.302	.377	.679
23	Reds	-53	2022	81	.407	33	48	2,656	367	653	121	7	89	353	252	47	720	25	18	2,975	1,055	217	5	15	6	62	.246	.321	.397	.718
24	Rangers	-54	2022	81	.420	34	47	2,676	342	646	110	10	101	323	235	21	683	68	17	2,952	1,079	221	5	15	9	45	.241	.306	.403	.709
25	Royals	-64	2022	81	.481	39	42	2,671	335	691	136	21	65	321	219	22	566	61	18	2,947	1,064	222	10	25	2	47	.259	.317	.398	.716