The Philadelphia Phillies had the highest run differential by a team at home in 2025, with a differential of 100 runs.

Interpreted as:

best run differential MLB teams at home this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	100	2025	81	.679	55	26	2,718	432	749	133	14	122	421	259	29	648	66	14	3,034	1,276	269	7	21	10	49	.276	.343	.469	.812
2	Dodgers	94	2025	81	.642	52	29	2,661	447	692	131	6	142	428	295	32	608	46	8	3,026	1,261	279	8	30	18	57	.260	.338	.474	.812
3	Blue Jays	94	2025	81	.667	54	27	2,694	431	729	153	7	104	416	259	34	523	36	15	3,023	1,208	264	17	19	12	62	.271	.340	.448	.788
4	Padres	89	2025	81	.642	52	29	2,604	364	647	100	12	77	343	289	24	534	58	13	2,968	1,002	189	26	25	15	50	.248	.326	.385	.711
5	Yankees	85	2025	81	.617	50	31	2,604	409	634	104	9	140	395	317	22	676	52	18	2,974	1,176	253	4	27	21	45	.243	.328	.452	.779
6	Brewers	77	2025	81	.642	52	29	2,627	382	644	125	12	83	357	287	37	620	75	21	2,996	1,042	220	18	27	8	40	.245	.325	.397	.722
7	Rangers	77	2025	81	.593	48	33	2,626	327	592	116	5	78	314	251	27	665	69	17	2,931	952	199	6	21	14	47	.225	.297	.363	.660
8	Mets	67	2025	81	.605	49	32	2,687	404	697	120	8	116	394	271	50	640	71	8	3,043	1,181	244	7	28	17	52	.259	.335	.440	.775
9	Cubs	67	2025	81	.617	50	31	2,642	391	641	122	18	103	380	289	28	625	100	18	2,993	1,108	243	7	27	11	40	.243	.321	.419	.740
10	Red Sox	62	2025	81	.593	48	33	2,712	395	711	177	13	86	379	254	37	637	72	20	3,033	1,172	276	8	22	11	55	.262	.331	.432	.763
11	Mariners	47	2025	81	.630	51	30	2,624	352	600	114	3	104	337	266	44	730	88	14	2,967	1,032	221	15	18	16	40	.229	.308	.393	.702
12	Tigers	44	2025	81	.568	46	35	2,665	398	685	133	23	104	377	257	34	704	36	8	2,985	1,176	260	3	26	6	45	.257	.327	.441	.769
13	Rays	34	2025	81	.506	41	40	2,678	372	699	121	6	96	357	260	24	666	108	24	2,989	1,120	223	9	18	6	62	.261	.330	.418	.748
14	Diamondbacks	30	2025	81	.531	43	38	2,683	411	689	142	27	104	398	270	43	600	53	16	3,054	1,197	273	22	36	13	64	.257	.330	.446	.777
15	Reds	29	2025	81	.556	45	36	2,675	365	672	120	10	87	347	259	22	682	50	15	2,980	1,073	217	4	20	8	49	.251	.320	.401	.721
16	Pirates	16	2025	81	.543	44	37	2,638	314	653	143	14	49	302	271	30	672	52	18	2,971	971	206	7	25	15	65	.248	.322	.368	.690
17	Cardinals	4	2025	81	.543	44	37	2,633	346	658	132	3	73	331	240	42	597	49	12	2,946	1,015	208	14	17	9	61	.250	.321	.385	.706
18	Royals	-7	2025	81	.531	43	38	2,625	301	653	145	16	70	295	220	28	526	49	27	2,912	1,040	231	15	24	9	47	.249	.311	.396	.707
19	Giants	-8	2025	81	.519	42	39	2,643	338	628	115	15	80	316	266	27	628	30	15	2,979	1,013	210	16	27	9	44	.238	.311	.383	.694
20	Guardians	-18	2025	81	.556	45	36	2,571	314	580	114	7	79	302	263	30	670	65	21	2,896	945	200	12	20	18	34	.226	.303	.368	.670
21	Astros	-28	2025	81	.568	46	35	2,624	319	653	113	5	81	306	233	36	639	36	8	2,927	1,019	199	7	27	7	69	.249	.316	.388	.704
22	Orioles	-29	2025	81	.481	39	42	2,664	362	644	139	7	106	343	233	36	716	64	19	2,958	1,115	252	3	22	7	50	.242	.309	.419	.728
23	Braves	-41	2025	81	.481	39	42	2,689	341	662	114	9	92	329	259	30	680	41	12	3,004	1,070	215	6	20	7	38	.246	.317	.398	.715
24	White Sox	-42	2025	81	.407	33	48	2,623	323	604	102	3	83	313	245	22	635	44	8	2,919	961	188	11	18	5	58	.230	.300	.366	.666
25	Marlins	-60	2025	81	.469	38	43	2,672	317	646	131	17	69	303	249	32	612	67	21	2,981	1,018	217	11	17	11	47	.242	.312	.381	.693