biggest run differencial by one team in a game in the past 16 years

Between June 25, 2009 and June 25, 2025, the Los Angeles Angels have the highest run differential by a team in a game, with a differential of 24 runs against the Rockies on June 24, 2023.

Interpreted as:

biggest run differencial by one team in a regular-season game in the past 16 years

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Angels	24	6/24/2023	LAA	@	COL	W 25-1	52	25	28	5	0	5	25	6	1	3	0	0	59	48	10	0	0	0	3	.538	.593	.923	1.516
2	Blue Jays	23	7/22/2022	TOR	@	BOS	W 28-5	57	28	29	5	0	5	28	5	1	9	0	0	63	49	10	0	0	0	0	.509	.556	.860	1.415
3	Reds	22	4/20/2025	CIN	@	BAL	W 24-2	51	24	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
4	Padres	21	5/10/2025	SDP	@	COL	W 21-0	50	21	24	4	1	5	20	5	0	4	0	0	56	45	10	0	1	0	0	.480	.518	.900	1.418
5	Cubs	21	4/23/2022	CHC	vs	PIT	W 21-0	48	21	23	4	0	1	19	4	1	3	2	0	53	30	5	0	0	0	1	.479	.528	.625	1.153
6	Dodgers	21	7/10/2021	LAD	vs	ARI	W 22-1	44	22	21	2	1	8	22	8	1	4	0	0	53	49	11	0	0	0	2	.477	.566	1.114	1.680
7	Astros	21	8/10/2019	HOU	@	BAL	W 23-2	50	23	25	7	0	6	21	2	0	4	0	0	52	50	13	0	0	0	3	.500	.519	1.000	1.519
8	Nationals	21	7/31/2018	WSH	vs	NYM	W 25-4	50	25	26	5	2	5	25	8	1	6	2	0	59	50	12	0	0	1	0	.520	.593	1.000	1.593
9	Phillies	21	7/6/2009	PHI	vs	CIN	W 22-1	43	22	21	6	0	4	21	7	1	9	0	0	52	39	10	0	1	0	1	.488	.558	.907	1.465
10	Braves	20	9/9/2020	ATL	vs	MIA	W 29-9	47	29	23	2	0	7	28	9	1	9	2	0	58	46	9	0	1	0	0	.489	.569	.979	1.548
11	Astros	20	9/8/2019	HOU	vs	SEA	W 21-1	47	21	22	11	0	2	19	7	1	8	0	0	55	39	13	0	0	0	0	.468	.545	.830	1.375
12	Mets	20	8/16/2018	NYM	@	PHI	W 24-4	52	24	25	7	1	3	19	7	1	5	1	0	61	43	11	1	0	1	2	.481	.550	.827	1.377
13	Brewers	20	4/22/2010	MIL	@	PIT	W 20-0	52	20	25	7	1	4	20	6	0	8	2	0	59	46	12	0	1	0	0	.481	.525	.885	1.410
14	Blue Jays	19	5/23/2023	TOR	@	TBR	W 20-1	52	20	27	3	1	4	18	1	0	9	2	0	54	44	8	0	1	0	1	.519	.519	.846	1.365
15	Braves	19	5/21/2021	ATL	vs	PIT	W 20-1	41	20	20	7	0	7	20	5	0	9	0	0	49	48	14	1	2	0	0	.488	.521	1.171	1.692
16	Brewers	19	9/9/2020	MIL	@	DET	W 19-0	45	19	21	8	0	5	18	7	2	6	0	1	54	44	13	0	0	0	2	.467	.556	.978	1.533
17	Phillies	19	4/7/2018	PHI	vs	MIA	W 20-1	42	20	20	4	0	4	20	6	0	11	0	0	49	36	8	0	1	0	1	.476	.531	.857	1.388
18	Angels	19	7/2/2016	LAA	@	BOS	W 21-2	50	21	22	6	1	4	19	3	1	5	0	0	55	42	11	0	1	0	0	.440	.473	.840	1.313
19	Braves	18	8/12/2023	ATL	@	NYM	W 21-3	48	21	22	5	0	6	21	6	1	8	3	0	55	45	11	0	0	0	0	.458	.527	.938	1.465
20	Braves	18	6/30/2021	ATL	vs	NYM	W 20-2	43	20	20	4	0	4	20	6	1	6	1	1	50	36	8	0	0	0	0	.465	.540	.837	1.377
21	Giants	18	9/1/2020	SFG	@	COL	W 23-5	52	23	27	8	1	4	23	5	1	6	1	0	59	49	13	0	1	0	0	.519	.559	.942	1.502
22	Athletics	18	9/20/2018	OAK	vs	LAA	W 21-3	44	21	22	4	0	3	20	7	0	7	0	0	51	35	7	0	0	0	2	.500	.569	.795	1.364
23	Astros	18	7/9/2017	HOU	@	TOR	W 19-1	45	19	17	4	0	5	16	8	1	7	1	0	54	36	9	0	0	0	1	.378	.481	.800	1.281
24	Nationals	18	4/30/2017	WSH	vs	NYM	W 23-5	46	23	23	4	0	7	23	6	0	6	0	0	54	48	11	1	1	3	0	.500	.547	1.043	1.591
25	Athletics	18	8/31/2012	OAK	vs	BOS	W 20-2	44	20	19	5	0	5	20	2	1	4	0	0	47	39	10	0	0	0	0	.432	.468	.886	1.354