The Chicago Cubs had their lowest run differential in a game on September 16, 1975 and on June 6, 1892, with a differential of -22 runs.

Interpreted as:

chicago cubs lowest run diff in a regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	-22	9/16/1975	CHC	vs	PIT	L 0-22	30	0	3	0	0	0	0	0	0	7	0	0	30	3	0	0	0	0	0	.100	.100	.100	.200
2	Colts	-22	6/6/1892	CHI	@	BAL	L 1-23		1
3	Cubs	-20	6/1/1957	CHC	@	CIN	L 2-22	33	2	6	0	1	0	1	4	1	2	0	0	39	8	1	0	1	0	0	.182	.282	.242	.524
4	Cubs	-19	7/6/1949	CHC	@	CIN	L 4-23	34	4	11	1	1	1	3	2	0	2	0		36	17	3	0			1	.324	.361	.500	.861
5	Cubs	-18	6/23/1986	CHC	@	PHI	L 1-19	32	1	6	1	0	0	1	1	0	2	0	0	34	7	1	1	0	0	1	.188	.212	.219	.431
6	Cubs	-18	4/27/1977	CHC	vs	STL	L 3-21	37	3	10	1	0	1	3	4	0	5	0	0	41	14	2	0	0	0	1	.270	.341	.378	.720
7	Cubs	-18	5/26/1964	CHC	vs	NYM	L 1-19	30	1	4	2	0	0	1	1	0	3	0	0	31	6	2	0	0	0	1	.133	.161	.200	.361
8	Colts	-18	7/17/1897	CHI	vs	BAL	L 2-20		2
9	Colts	-18	9/7/1891	CHI	@	BKN	L 3-21		3
10	Cubs	-17	4/27/2024	CHC	@	BOS	L 0-17	32	0	5	1	0	0	0	2	1	7	0	0	35	6	1	0	0	0	0	.156	.229	.188	.416
11	Cubs	-17	8/2/2010	CHC	vs	MIL	L 1-18	31	1	4	4	0	0	1	1	0	14	0	0	32	8	4	0	0	0	0	.129	.156	.258	.414
12	Cubs	-17	5/20/1996	CHC	@	ATL	L 1-18	33	1	7	2	0	0	1	1	0	7	0	0	34	9	2	0	0	0	1	.212	.235	.273	.508
13	Cubs	-17	9/4/1988	CHC	vs	CIN	L 0-17	30	0	6	1	0	0	0	0	0	3	0	0	30	7	1	0	0	0	3	.200	.200	.233	.433
14	Cubs	-17	7/3/1904	CHC	vs	SLN	L 2-19	33	2	7	2	0	0		1	0	5	0		36	9	2	2				.212	.235	.273	.508
15	Colts	-17	6/13/1895	CHI	@	BSN	L 3-20		3
16	Colts	-17	9/10/1894	CHI	vs	BSN	L 8-25		8
17	White Stockings	-17	6/8/1888	CWS	@	NYG	L 2-19		2
18	Cubs	-16	6/27/2012	CHC	vs	NYM	L 1-17	34	1	9	2	0	0	1	1	0	8	0	1	35	11	2	0	0	0	1	.265	.286	.324	.609
19	Cubs	-16	7/4/1977	CHC	vs	MON	L 3-19	33	3	9	2	0	0	3	2	0	5	1	0	36	11	2	0	1	0	2	.273	.306	.333	.639
20	Cubs	-16	4/29/1974	CHC	@	HOU	L 2-18	33	2	7	2	0	0	2	3	0	3	0	0	36	9	2	0	0	0	2	.212	.278	.273	.551
21	Cubs	-16	7/4/1961	CHC	vs	SFG	L 3-19	31	3	5	3	0	1	3	1	0	13	0	0	32	11	4	0	0	0	1	.161	.188	.355	.542
22	Cubs	-16	4/23/1960	CHC	vs	SFG	L 2-18	30	2	5	1	0	0	2	4	0	5	0	0	34	6	1	0	0	0	2	.167	.265	.200	.465
23	Colts	-16	5/29/1893	CHI	@	BSN	L 2-18		2
24	White Stockings	-16	8/7/1882	CWS	@	BOS	L 2-18		2
25	Cubs	-15	5/26/2022	CHC	@	CIN	L 5-20	35	5	8	2	0	3	5	2	1	8	2	0	38	19	5	0	0	0	1	.229	.289	.543	.832