Sammy Sosa has launched the most career homers for the Cubs against left-handed pitchers, with 121 home runs.

	NAME	HR	G	AB	H	2B	3B	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Sammy Sosa S. Sosa	121	811	1,585	479	70	8	305	283	2	417	1,878	928	199	1	7	68	.302	.407	.585	.993
2	Ryne Sandberg R. Sandberg	72	1,009	2,289	683	134	21	268	263	4	304	2,573	1,075	227	3	14	34	.298	.370	.470	.839
3	Aramis Ramirez A. Ramirez	60	414	930	277	60	2	196	90	11	137	1,041	521	122	0	10	10	.298	.363	.560	.923
4	Anthony Rizzo A. Rizzo	59	788	1,329	339	57	2	232	151	62	248	1,552	577	118	0	10	4	.255	.356	.434	.790
5	Andre Dawson A. Dawson	52	442	1,013	299	50	7	181	66	6	127	1,103	519	109	0	18	29	.295	.336	.512	.849
6	Alfonso Soriano A. Soriano	51	388	871	238	58	2	137	83	3	207	964	453	111	1	6	19	.273	.336	.520	.857
7	Kris Bryant K. Bryant	49	393	704	215	48	3	130	122	9	200	839	416	100	0	4	11	.305	.412	.591	1.003
8	Mark Grace M. Grace	43	1,144	2,298	680	134	12	323	238	15	242	2,585	967	189	9	25	5	.296	.362	.421	.783
9	Javier Báez J. Báez	41	374	678	198	36	4	127	50	6	189	739	365	81	0	5	13	.292	.344	.538	.882
10	Shawon Dunston S. Dunston	41	580	1,307	354	64	16	159	45	5	180	1,377	573	121	4	16	11	.271	.294	.438	.733
11	Derrek Lee D. Lee	40	349	782	238	61	2	129	134	5	138	928	423	103	0	7	11	.304	.406	.541	.947
12	Willson Contreras W. Contreras	34	352	636	170	41	4	96	82	13	166	735	321	79	1	3	6	.267	.361	.505	.866
13	Patrick Wisdom P. Wisdom	32	263	442	97	18	2	70	42	8	187	494	215	52	1	1	2	.219	.298	.486	.785
14	Ron Cey R. Cey	32	251	490	122	28	0	86	77	7	100	579	246	60	0	5	15	.249	.356	.502	.858
15	Keith Moreland K. Moreland	30	411	814	257	42	5	123	121	3	89	953	399	77	3	12	27	.316	.401	.490	.891
16	Jody Davis J. Davis	29	446	886	229	43	4	109	91	2	139	993	367	76	3	11	22	.258	.325	.414	.739
17	Dave Kingman D. Kingman	29	186	387	110	21	3	76	48	3	93	446	224	53	1	7	12	.284	.362	.579	.941
18	Ian Happ I. Happ	28	548	918	226	45	4	110	92	9	286	1,026	363	77	4	3	3	.246	.320	.395	.715
19	Jose Hernandez J. Hernandez	26	310	564	137	22	11	78	45	1	148	618	259	59	5	3	2	.243	.299	.459	.758
20	Geovany Soto G. Soto	24	245	498	149	30	0	80	79	4	107	585	251	54	0	4	5	.299	.397	.504	.901
21	Glenallen Hill G. Hill	24	201	425	139	14	3	72	37	0	89	462	231	41	0	0	2	.327	.381	.544	.924
22	Luis Salazar L. Salazar	21	229	512	141	23	3	73	23	1	57	542	233	47	3	3	4	.275	.306	.455	.761
23	Seiya Suzuki S. Suzuki	19	248	434	127	27	5	69	65	2	92	505	221	51	0	4	7	.293	.384	.509	.893
24	Michael Barrett M. Barrett	19	183	355	103	30	5	56	45	2	39	406	200	54	2	2	3	.290	.371	.563	.935
25	Leon Durham L. Durham	19	419	737	193	30	9	106	89	5	189	834	298	58	0	3	4	.262	.344	.404	.748