The Chicago Cubs had their most runs in a game in 1927 versus the Pirates on April 28, 1927, with 16 runs.

Interpreted as:

cubs most runs in a regular-season game 1927

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Cubs	16	4/28/1927	CHC	@	PIT	W 16-4	40	17	2	1	1	14	8	0	5	2	0	52	24	4	4	.425	.521	.600	1.121
2	Cubs	14	6/19/1927	CHC	vs	PIT	W 14-7	38	14	3	0	1	13	6	1	2	0	0	46	20	4	1	.368	.467	.526	.993
3	Cubs	13	8/24/1927	CHC	@	PHN	W 13-1	47	22	9	0	2	12	4	0	4	1	0	52	37	11	1	.468	.510	.787	1.297
4	Cubs	13	5/4/1927	CHC	vs	CIN	W 13-9	38	15	5	0	1	13	3	0	2	0	0	45	23	6	4	.395	.439	.605	1.044
5	Cubs	12	8/3/1927	CHC	vs	BSN	W 12-1	38	15	3	0	0	12	7	1	4	0	0	46	18	3	0	.395	.500	.474	.974
6	Cubs	12	7/31/1927	CHC	vs	PHN	W 12-5	36	12	6	0	1	11	2	0	4	0	0	39	21	7	1	.333	.368	.583	.952
7	Cubs	12	6/15/1927	CHC	vs	PHN	W 12-5	36	18	3	2	0	10	6	0	3	0	0	44	25	5	2	.500	.571	.694	1.266
8	Cubs	11	9/8/1927	CHC	@	SLN	W 11-7	39	16	2	4	0	9	4	0	5	2	0	45	26	6	2	.410	.465	.667	1.132
9	Cubs	11	6/27/1927	CHC	@	CIN	W 11-4	38	14	2	1	0	8	2	2	6	3	0	46	18	3	4	.368	.429	.474	.902
10	Cubs	11	5/26/1927	CHC	vs	CIN	W 11-2	39	17	3	0	0	11	2	0	3	1	0	43	20	3	2	.436	.463	.513	.976
11	Cubs	11	5/21/1927	CHC	@	BKN	W 11-6	36	12	3	1	1	10	9	0	4	1	0	47	20	5	2	.333	.467	.556	1.022
12	Cubs	10	9/24/1927	CHC	vs	PHN	W 10-2	32	14	1	2	2	10	3	1	1	0	0	41	25	5	5	.438	.500	.781	1.281
13	Cubs	10	9/23/1927	CHC	vs	PHN	W 10-0	39	17	5	1	0	9	3	1	3	0	0	44	24	6	1	.436	.488	.615	1.104
14	Cubs	10	8/27/1927	CHC	@	PHN	W 10-6	44	19	3	0	0	9	1	0	5	0	0	47	22	3	2	.432	.444	.500	.944
15	Cubs	10	4/12/1927	CHC	vs	SLN	W 10-1	32	12	2	0	3	10	5	0	2	0	0	38	23	5	1	.375	.459	.719	1.178
16	Cubs	9	7/15/1927	CHC	@	BSN	W 9-6	37	16	4	1	0	7	4	0	2	0	0	45	22	5	4	.432	.488	.595	1.082
17	Cubs	9	5/31/1927	CHC	@	PIT	L 9-10	39	13	3	0	1	8	2	0	5	0	0	44	19	4	3	.333	.366	.487	.853
18	Cubs	9	4/25/1927	CHC	@	CIN	L 9-11	33	12	0	2	0	9	3	0	1	0	0	40	16	2	4	.364	.417	.485	.902
19	Cubs	8	9/22/1927	CHC	vs	PHN	W 8-4	29	9	2	0	1	8	5	1	3	1	0	37	14	3	2	.310	.429	.483	.911
20	Cubs	8	9/20/1927	CHC	vs	BSN	W 8-5	34	13	1	1	1	7	2	0	2	0	0	38	19	3	2	.382	.417	.559	.975
21	Cubs	8	9/7/1927	CHC	@	SLN	W 8-4	33	10	0	0	3	7	6	1	2	0	0	42	19	3	2	.303	.425	.576	1.001
22	Cubs	8	8/25/1927	CHC	@	PHN	W 8-0	37	13	0	0	0	7	2	1	2	1	0	42	13	0	2	.351	.400	.351	.751
23	Cubs	8	7/19/1927	CHC	@	NYG	W 8-5	37	13	1	0	2	8	4	0	3	2	0	43	20	3	2	.351	.415	.541	.955
24	Cubs	8	7/5/1927	CHC	vs	CIN	W 8-5	32	11	3	0	0	8	3	0	0	0	0	37	14	3	2	.344	.400	.438	.838
25	Cubs	8	6/4/1927	CHC	vs	BSN	L 8-10	38	11	3	1	2	8	3	0	2	0	0	42	22	6	1	.289	.341	.579	.920