Derek Lowe was 70-55 with an ERA of 3.72, 673 strikeouts and 85 saves in 384 appearances for the Red Sox in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Lowe | 1997 |  BOS | 8 | 0 | 2 | .000 | 0 | 3.38 | 13 | 0 | 0 | 0 | 16.0 | 15 | 6 | 6 | 0 | 3 | 2 | 0 | 1 | 64 | 0 | 7.31 | 1.69 | 4.33 | 0.00 | 20.3 | 4.7 | 1.13 | .326 | 3.38 | 73 | 2.41 | 54 | 8.44 | 3.7 |
| 2 | | D. Lowe | 1998 | BOS | 63 | 3 | 9 | .250 | 10 | 4.02 | 77 | 0 | 0 | 4 | 123.0 | 126 | 55 | 65 | 5 | 42 | 4 | 8 | 5 | 527 | 8 | 5.63 | 3.07 | 1.83 | 0.37 | 14.6 | 8.0 | 1.37 | .303 | 4.76 | 85 | 3.53 | 79 | 9.22 | 13.1 |
| 3 | | D. Lowe | 1999 | BOS | 74 | 6 | 3 | .667 | 0 | 2.63 | 80 | 0 | 0 | 15 | 109.1 | 84 | 32 | 35 | 7 | 25 | 4 | 32 | 1 | 436 | 1 | 6.59 | 2.06 | 3.20 | 0.58 | 18.3 | 5.7 | 1.00 | .241 | 2.88 | 54 | 3.29 | 71 | 6.91 | 16.9 |
| 4 | | D. Lowe | 2000 | BOS | 74 | 4 | 4 | .500 | 0 | 2.56 | 79 | 0 | 0 | 42 | 91.1 | 90 | 26 | 27 | 6 | 22 | 2 | 64 | 5 | 379 | 2 | 7.78 | 2.17 | 3.59 | 0.59 | 20.8 | 5.8 | 1.23 | .311 | 2.66 | 52 | 3.04 | 66 | 8.87 | 16.6 |
| 5 | | D. Lowe | 2001 | BOS | 67 | 5 | 10 | .333 | 3 | 3.53 | 82 | 0 | 0 | 24 | 91.2 | 103 | 36 | 39 | 7 | 29 | 5 | 50 | 9 | 404 | 4 | 8.05 | 2.85 | 2.83 | 0.69 | 20.3 | 7.2 | 1.44 | .342 | 3.83 | 77 | 3.36 | 78 | 10.11 | 9.7 |
| 6 | | D. Lowe | 2002 | BOS | 32 | 21 | 8 | .724 | 32 | 2.58 | 127 | 1 | 1 | 0 | 219.2 | 166 | 63 | 65 | 12 | 48 | 12 | 0 | 0 | 854 | 5 | 5.20 | 1.97 | 2.65 | 0.49 | 14.9 | 5.6 | 0.97 | .235 | 2.66 | 57 | 3.33 | 79 | 6.80 | 22.4 |
| 7 | | D. Lowe | 2003 | BOS | 33 | 17 | 7 | .708 | 33 | 4.47 | 110 | 1 | 0 | 0 | 203.1 | 216 | 101 | 113 | 17 | 72 | 11 | 0 | 4 | 886 | 3 | 4.87 | 3.19 | 1.53 | 0.75 | 12.4 | 8.1 | 1.42 | .294 | 5.00 | 97 | 4.25 | 97 | 9.56 | 2.5 |
| 8 | | D. Lowe | 2004 | BOS | 33 | 14 | 12 | .538 | 33 | 5.42 | 105 | 0 | 0 | 0 | 182.2 | 224 | 110 | 138 | 15 | 71 | 8 | 0 | 2 | 839 | 3 | 5.17 | 3.50 | 1.48 | 0.74 | 12.5 | 8.5 | 1.61 | .327 | 6.80 | 115 | 4.26 | 97 | 11.04 | 2.4 |
| Total | 384 | 70 | 55 | .560 | 111 | 3.72 | 673 | 2 | 1 | 85 | 1037.0 | 1,024 | 429 | 488 | 69 | 312 | 48 | 154 | 27 | 4,389 | 26 | 5.84 | 2.71 | 2.16 | 0.60 | 15.3 | 7.1 | 1.29 | .291 | 4.24 | 79 | 3.66 | 83 | 8.89 | 87.3 |
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