Brent Rooker has the fewest career games with >0 games played with 100+ home runs, with 525 games.

Interpreted as:

fewest regular-season games played by a player to reach 100 or more hr

	NAME	G	HR	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Brent Rooker B. Rooker	525	109	1,875	265	486	99	6	293	191	32	590	21	4	2,108	924	214	0	10	9	32	.259	.336	.493	.829
2	Franmil Reyes F. Reyes	548	108	1,881	237	468	73	4	285	172	5	635	6	2	2,078	873	185	0	20	4	54	.249	.310	.464	.775
3	Mike Jacobs M. Jacobs	569	100	1,949	248	493	116	6	312	170	7	492	5	2	2,140	921	222	1	13	18	49	.253	.313	.473	.786
4	Luis Robert Jr. L. Robert Jr.	577	102	2,178	318	565	115	2	298	149	25	636	102	24	2,364	990	219	1	11	12	40	.259	.313	.455	.767
5	Jazz Chisholm Jr. J. Chisholm Jr.	579	108	2,109	316	522	79	16	308	197	20	648	130	36	2,344	957	203	4	14	6	16	.248	.316	.454	.770
6	Julio Rodríguez J. Rodríguez	590	112	2,384	368	654	110	9	341	169	37	628	116	28	2,597	1,118	231	0	7	16	46	.274	.331	.469	.800
7	Cal Raleigh C. Raleigh	623	153	2,164	313	489	95	2	376	266	19	696	21	5	2,465	1,047	250	0	16	22	27	.226	.314	.484	.798
8	Bobby Witt Jr. B. Witt Jr.	626	105	2,491	403	722	151	34	373	176	26	487	148	43	2,722	1,256	290	1	28	20	34	.290	.340	.504	.844
9	Marcus Thames M. Thames	640	115	1,827	256	450	83	4	301	159	14	510	3	9	2,016	886	202	0	16	4	30	.246	.309	.485	.794
10	Tyler O'Neill T. O'Neill	644	118	2,056	335	498	91	4	304	211	32	701	48	9	2,318	951	213	0	19	6	43	.242	.320	.463	.782
11	Mitch Garver M. Garver	651	106	2,043	284	475	92	7	309	264	26	630	5	2	2,348	899	205	1	14	4	43	.233	.326	.440	.766
12	Jack Cust J. Cust	670	105	2,107	311	510	96	2	323	444	12	819	6	6	2,581	925	203	0	18	12	32	.242	.374	.439	.813
13	Fernando Tatis Jr. F. Tatis Jr.	671	152	2,603	476	721	136	12	393	293	28	690	124	27	2,939	1,337	300	1	14	15	46	.277	.355	.514	.868
14	Yordan Alvarez Y. Alvarez	677	170	2,455	429	728	156	6	493	346	40	566	9	2	2,867	1,406	332	0	26	42	60	.297	.389	.573	.961
15	Bo Jackson B. Jackson	694	141	2,393	341	598	86	14	415	200	14	841	82	32	2,626	1,135	241	2	17	20	40	.250	.309	.474	.784
16	Taylor Ward T. Ward	704	113	2,494	359	615	124	8	345	280	31	689	24	11	2,833	1,094	245	2	26	1	44	.247	.327	.439	.766
17	Evan Gattis E. Gattis	706	139	2,443	299	605	116	12	410	167	26	575	3	3	2,662	1,162	267	0	26	18	67	.248	.300	.476	.775
18	Will Smith W. Smith	722	128	2,508	413	661	128	10	442	330	64	554	12	4	2,946	1,193	266	0	44	19	50	.264	.358	.476	.834
19	Miguel Sanó M. Sanó	722	164	2,585	395	602	126	6	424	342	15	1,078	5	3	2,954	1,232	296	0	12	10	54	.233	.325	.477	.801
20	Kal Daniels K. Daniels	727	104	2,338	391	666	125	8	360	365	14	493	87	26	2,739	1,119	237	4	18	28	51	.285	.382	.479	.861
21	Morgan Ensberg M. Ensberg	731	110	2,204	340	579	102	10	347	332	21	436	22	19	2,580	1,031	222	8	15	18	58	.263	.362	.468	.830
22	Travis Shaw T. Shaw	733	114	2,374	310	563	127	3	366	275	20	650	20	4	2,690	1,038	244	4	17	20	49	.237	.319	.437	.757
23	Ramón Laureano R. Laureano	742	106	2,548	378	645	148	11	328	202	70	762	72	23	2,841	1,133	265	1	20	1	48	.253	.323	.445	.768
24	Josh Naylor J. Naylor	745	104	2,590	334	697	146	2	435	221	23	457	55	9	2,856	1,159	252	0	22	26	71	.269	.329	.447	.777
25	Brandon Lowe B. Lowe	745	157	2,657	415	657	126	12	446	282	36	817	33	5	2,994	1,278	295	0	19	7	30	.247	.326	.481	.807