Since 2000, Luke Hudson has the highest ERA in a game, with an ERA of 270.00 versus the Cleveland Indians on August 13, 2006.

Interpreted as:

highest era by a player in a single regular-season game since 2000

	NAME	ERA	DATE	TM		OPP	DEC	GS	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Luke Hudson L. Hudson	270.00	8/13/2006	KCR	@	CLE	L	1	1	0	0	0	0.1	8	10	11	1	3	0	0	0	13	0
2	Mark Redman M. Redman	243.00	9/23/2006	KCR	vs	DET	L	1	0	0	0	0	0.1	7	9	9	1	2	0	0	0	10	0
3	Jose Mesa J. Mesa	243.00	5/28/2000	SEA	@	TBD	L	0	0	0	0	0	0.1	7	9	9	1	2	0	0	0	10	0
4	Paolo Espino P. Espino	216.00	7/18/2023	WSH	@	CHC		0	1	0	0	0	0.1	7	8	8	0	2	0	0	0	10	0
5	Cody Bolton C. Bolton	216.00	5/29/2023	PIT	@	SFG		0	0	0	0	0	0.1	6	8	8	1	2	0	0	0	9	0
6	Matt Shoemaker M. Shoemaker	216.00	6/4/2021	MIN	@	KCR	L	1	1	0	0	0	0.1	6	8	9	1	2	0	0	0	10	0
7	Taylor Williams T. Williams	216.00	6/4/2019	MIL	vs	MIA		0	1	0	0	0	0.1	6	8	8	0	2	0	0	1	9	0
8	Felix Hernandez F. Hernandez	216.00	6/12/2015	SEA	@	HOU	L	1	1	0	0	0	0.1	5	8	8	2	2	0	0	0	9	0
9	Philip Humber P. Humber	216.00	4/20/2013	HOU	vs	CLE	L	1	0	0	0	0	0.1	8	8	8	1	1	0	0	0	10	0
10	Philip Humber P. Humber	216.00	9/4/2012	CWS	vs	MIN		0	0	0	0	0	0.1	7	8	8	1	2	0	0	0	10	0
11	Madison Bumgarner M. Bumgarner	216.00	6/21/2011	SFG	vs	MIN	L	1	1	0	0	0	0.1	9	8	8	0	0	0	0	0	10	0
12	Jason Miller J. Miller	216.00	6/4/2007	MIN	@	LAA		0	0	0	0	0	0.1	7	8	8	2	2	0	0	1	10	0
13	Lance McCullers Jr. L. McCullers Jr.	189.00	5/10/2025	HOU	vs	CIN	L	1	0	0	0	0	0.1	3	7	7	1	3	1	0	0	8	0
14	Jhonathan Díaz J. Díaz	189.00	9/15/2023	LAA	vs	DET		0	0	0	0	0	0.1	7	7	7	0	2	0	0	0	10	0
15	Roansy Contreras R. Contreras	189.00	6/7/2023	PIT	vs	OAK	L	1	1	0	0	0	0.1	6	7	7	0	2	0	0	0	9	0
16	Paolo Espino P. Espino	189.00	10/4/2022	WSH	@	NYM	L	1	0	0	0	0	0.1	5	7	7	3	2	0	0	0	8	0
17	Tyler Rogers T. Rogers	189.00	5/24/2022	SFG	vs	NYM		0	0	0	0	0	0.1	7	7	7	0	0	0	0	0	8	0
18	Spenser Watkins S. Watkins	189.00	9/12/2021	BAL	vs	TOR		0	0	0	0	0	0.1	7	7	7	2	1	0	0	0	8	0
19	Matt Peacock M. Peacock	189.00	5/1/2021	ARI	vs	COL		0	0	0	0	0	0.1	6	7	7	1	1	0	0	0	8	0
20	Nestor Cortes N. Cortes	189.00	8/14/2020	SEA	@	HOU	L	1	1	0	0	0	0.1	5	7	8	2	2	0	0	0	9	0
21	Wade Miley W. Miley	189.00	9/10/2019	HOU	vs	OAK	L	1	0	0	0	0	0.1	7	7	7	0	1	0	0	0	9	0
22	Jimmy Yacabonis J. Yacabonis	189.00	7/20/2019	BAL	vs	BOS		0	0	0	0	0	0.1	8	7	7	1	1	0	0	0	10	2
23	Felix Pena F. Pena	189.00	7/29/2018	LAA	vs	SEA	L	1	1	0	0	0	0.1	6	7	7	0	2	0	0	0	9	1
24	T.J. McFarland	189.00	8/20/2017	ARI	@	MIN	L	1	0	0	0	0	0.1	5	7	7	0	2	0	0	0	8	0
25	Glenn Sparkman G. Sparkman	189.00	7/2/2017	TOR	vs	BOS		0	1	0	0	0	0.1	7	7	7	0	0	0	0	0	8	0