Barry Bonds has the highest isolated power with 100+ games played in a season, with an isolated power of .536 in 2001.

Interpreted as:

highest iso by a player season minimum 100 games

	NAME	ISO	G	SEASON	TM	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Barry Bonds B. Bonds	.536	153	2001	SFG	476	129	156	32	2	73	137	177	9	93	13	3	664	411	107	0	2	35	5	.328	.515	.863	1.379	200	117.7	.537	234	116.6
2	Babe Ruth B. Ruth	.472	142	1920	NYY	458	158	172	36	9	54	135	150	3	80	14	14	616	388	99	5				.376	.532	.847	1.379	191	120.9	.597	237	110.5
3	Babe Ruth B. Ruth	.469	152	1921	NYY	540	177	204	44	16	59	168	145	4	81	17	13	693	457	119	4				.378	.512	.846	1.359	214	127.8	.575	224	118.7
4	Mark McGwire M. McGwire	.454	155	1998	STL	509	130	152	21	0	70	147	162	6	155	1	0	681	383	91	0	4	28	8	.299	.470	.752	1.222	176	91.7	.492	205	90.7
5	Barry Bonds B. Bonds	.450	147	2004	SFG	373	129	135	27	3	45	101	232	9	41	6	1	617	303	75	0	3	120	5	.362	.609	.812	1.422	185	108	.537	233	105.7
6	Barry Bonds B. Bonds	.429	143	2002	SFG	403	117	149	31	2	46	110	198	9	47	9	2	612	322	79	0	2	68	4	.370	.582	.799	1.381	183	110	.544	244	109.9
7	Mark McGwire M. McGwire	.418	130	1996	OAK	423	104	132	21	0	52	113	116	8	112	0	0	548	309	73	0	1	16	14	.312	.467	.730	1.198	142	71.8	.489	190	68.5
8	Mark McGwire M. McGwire	.418	153	1999	STL	521	118	145	21	1	65	147	133	2	141	0	0	661	363	87	0	5	21	12	.278	.424	.697	1.120	150	64.2	.453	169	61.5
9	Babe Ruth B. Ruth	.417	151	1927	NYY	540	158	192	29	8	60	165	137	0	89	7	6	691	417	97	14				.356	.486	.772	1.258	195	109.9	.545	212	104.8
10	Mark McGwire M. McGwire	.410	104	1995	OAK	317	75	87	13	0	39	90	88	11	77	1	1	422	217	52	0	6	5	9	.274	.441	.685	1.125	99	46.7	.466	183	45.9
11	Sammy Sosa S. Sosa	.409	160	2001	CHC	577	146	189	34	5	64	160	116	6	153	0	2	711	425	103	0	12	37	6	.328	.437	.737	1.174	171	82.7	.465	186	79.8
12	Barry Bonds B. Bonds	.408	130	2003	SFG	390	111	133	22	1	45	90	148	10	58	7	0	550	292	68	0	2	61	7	.341	.529	.749	1.278	148	80.5	.503	212	79.4
13	Lou Gehrig L. Gehrig	.392	155	1927	NYY	584	149	218	52	18	47	173	109	3	84	10	8	717	447	117	21				.373	.474	.765	1.240	199	110.9	.540	209	105.6
14	J.D. Martinez	.387	119	2017	TOT	432	85	131	26	3	45	104	53	0	128	4	0	489	298	74	0	4	8	23	.303	.376	.690	1.066	105	45.1	.430	167	41.2
15	Babe Ruth B. Ruth	.386	154	1928	NYY	536	163	173	29	8	54	146	137	3	87	4	5	684	380	91	8				.323	.463	.709	1.172	174	90.6	.510	201	89.3
16	Jimmie Foxx J. Foxx	.385	154	1932	PHA	585	151	213	33	9	58	169	116	0	96	3	7	701	438	100	0				.364	.469	.749	1.218	193	105.6	.522	198	95.8
17	Jeff Bagwell J. Bagwell	.383	110	1994	HOU	400	104	147	32	2	39	116	65	4	65	15	4	479	300	73	0	10	14	12	.368	.451	.750	1.201	123	62.6	.488	206	65.2
18	Barry Bonds B. Bonds	.381	143	2000	SFG	480	129	147	28	4	49	106	117	3	77	11	3	607	330	81	0	7	22	6	.306	.440	.688	1.127	141	61	.456	174	61.2
19	Aaron Judge A. Judge	.379	158	2024	NYY	559	122	180	36	1	58	144	133	9	171	10	0	703	392	95	0	2	20	22	.322	.458	.701	1.159	176	93.7	.476	219	95.5
20	Frank Thomas F. Thomas	.376	113	1994	CWS	399	106	141	34	1	38	101	109	2	61	2	3	517	291	73	0	7	12	15	.353	.487	.729	1.217	138	72.3	.499	205	71.9
21	Aaron Judge A. Judge	.375	157	2022	NYY	570	133	177	28	0	62	131	111	6	175	16	3	692	391	90	0	5	19	14	.311	.425	.686	1.111	161	81.6	.458	208	84.5
22	Albert Belle A. Belle	.374	143	1995	CLE	546	121	173	52	1	50	126	73	6	80	5	2	629	377	103	0	4	5	24	.317	.401	.690	1.091	143	64.3	.456	173	59.9
23	Jim Thome J. Thome	.373	147	2002	CLE	480	101	146	19	2	52	118	122	5	139	1	2	613	325	73	0	6	18	5	.304	.445	.677	1.122	142	68.3	.461	189	67.1
24	Babe Ruth B. Ruth	.373	145	1930	NYY	518	150	186	28	9	49	153	136	1	61	10	10	676	379	86	21				.359	.493	.732	1.225	192	97	.517	204	100.6
25	Mark McGwire M. McGwire	.372	156	1997	TOT	540	86	148	27	0	58	123	101	9	159	3	0	657	349	85	0	7	16	9	.274	.393	.646	1.039	134	52.9	.429	161	51.4