highest run difference in an mlb game in 2019

The Houston Astros had the highest run differential by a team in a game in 2019, with a differential of 21 runs against the Orioles on August 10, 2019.

Interpreted as:

highest run difference in an MLB regular-season game in 2019

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	21	8/10/2019	HOU	@	BAL	W 23-2	50	23	25	7	0	6	21	2	0	4	0	0	52	50	13	0	0	0	3	.500	.519	1.000	1.519
2	Astros	20	9/8/2019	HOU	vs	SEA	W 21-1	47	21	22	11	0	2	19	7	1	8	0	0	55	39	13	0	0	0	0	.468	.545	.830	1.375
3	Giants	17	7/15/2019	SFG	@	COL	W 19-2	46	19	21	6	0	4	19	3	1	5	0	0	52	39	10	2	0	0	1	.457	.500	.848	1.348
4	Red Sox	16	7/25/2019	BOS	vs	NYY	W 19-3	46	19	23	10	0	4	19	5	0	6	0	0	51	45	14	0	0	0	0	.500	.549	.978	1.527
5	Marlins	16	6/4/2019	MIA	@	MIL	W 16-0	47	16	19	5	0	3	16	3	0	9	0	0	50	33	8	0	0	1	0	.404	.440	.702	1.142
6	Diamondbacks	16	5/24/2019	ARI	@	SFG	W 18-2	49	18	21	1	0	4	17	3	3	12	0	0	55	34	5	0	0	0	0	.429	.491	.694	1.185
7	Astros	15	9/9/2019	HOU	vs	OAK	W 15-0	39	15	17	0	1	7	14	2	0	2	0	0	41	40	8	0	0	0	3	.436	.463	1.026	1.489
8	Athletics	15	8/26/2019	OAK	@	KCR	W 19-4	49	19	22	2	1	4	19	6	0	8	0	0	55	38	7	0	0	0	0	.449	.509	.776	1.285
9	Blue Jays	15	8/12/2019	TOR	vs	TEX	W 19-4	43	19	21	9	0	4	19	4	0	7	1	1	47	42	13	0	0	0	0	.488	.532	.977	1.509
10	Diamondbacks	15	7/17/2019	ARI	@	TEX	W 19-4	47	19	21	5	0	5	19	8	3	9	0	0	59	41	10	0	1	0	0	.447	.542	.872	1.415
11	Padres	15	5/25/2019	SDP	@	TOR	W 19-4	45	19	20	2	0	7	19	6	3	11	1	0	54	43	9	0	0	0	2	.444	.537	.956	1.493
12	Rangers	15	5/16/2019	TEX	@	KCR	W 16-1	47	16	21	2	0	5	14	8	0	6	0	0	56	38	7	0	1	0	1	.447	.518	.809	1.326
13	Athletics	14	9/10/2019	OAK	@	HOU	W 21-7	51	21	25	3	0	6	21	4	0	7	0	0	56	46	9	0	1	0	0	.490	.518	.902	1.420
14	Astros	14	8/27/2019	HOU	vs	TBR	W 15-1	40	15	18	4	1	3	14	3	2	7	0	1	46	33	8	0	1	0	0	.450	.500	.825	1.325
15	Pirates	14	8/24/2019	PIT	vs	CIN	W 14-0	33	14	10	2	0	2	13	4	2	5	0	0	40	18	4	1	0	0	0	.303	.410	.545	.956
16	Indians	14	8/15/2019	CLE	@	NYY	W 19-5	49	19	24	4	0	7	19	4	1	8	0	0	54	49	11	0	0	0	1	.490	.537	1.000	1.537
17	Dodgers	14	8/13/2019	LAD	@	MIA	W 15-1	43	15	15	6	1	6	14	5	0	7	0	0	48	41	13	0	0	0	0	.349	.417	.953	1.370
18	Dodgers	14	7/15/2019	LAD	@	PHI	W 16-2	44	16	19	5	0	4	15	5	1	7	2	0	53	36	9	2	1	0	0	.432	.490	.818	1.308
19	Athletics	14	6/18/2019	OAK	vs	BAL	W 16-2	40	16	15	3	1	6	15	3	1	6	0	0	44	38	10	0	0	0	0	.375	.432	.950	1.382
20	Braves	14	6/16/2019	ATL	vs	PHI	W 15-1	40	15	19	5	0	3	14	2	2	10	0	0	46	33	8	1	1	1	1	.475	.511	.825	1.336
21	Twins	14	5/18/2019	MIN	@	SEA	W 18-4	46	18	19	5	0	6	18	6	0	5	0	0	53	42	11	0	1	0	0	.413	.472	.913	1.385
22	Athletics	14	5/16/2019	OAK	@	DET	W 17-3	44	17	16	3	1	5	16	5	1	8	0	0	50	36	9	0	0	0	0	.364	.440	.818	1.258
23	Rangers	14	4/27/2019	TEX	@	SEA	W 15-1	49	15	20	7	0	3	15	5	1	7	0	0	55	36	10	0	0	0	0	.408	.473	.735	1.207
24	Nationals	14	4/10/2019	WSH	@	PHI	W 15-1	44	15	17	3	1	0	14	6	0	11	0	0	51	22	4	0	1	0	1	.386	.451	.500	.951
25	Reds	14	4/9/2019	CIN	vs	MIA	W 14-0	38	14	16	3	0	5	13	6	1	9	0	0	45	34	8	0	0	1	0	.421	.511	.895	1.406