The Chicago Cubs have the highest run differential by a team this season, with a differential of 106 runs.

Interpreted as:

highest run differential in a team this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	106	2025	62	.629	39	23	2,159	356	565	117	15	83	348	233	17	488	82	14	2,437	961	215	6	22	8	29	.262	.335	.445	.780
2	Yankees	99	2025	61	.623	38	23	2,063	326	531	109	10	98	313	249	30	533	43	14	2,367	954	217	1	24	18	40	.257	.342	.462	.805
3	Tigers	91	2025	64	.641	41	23	2,171	317	544	100	10	74	303	213	27	573	22	6	2,431	886	184	4	16	6	37	.251	.323	.408	.731
4	Dodgers	76	2025	63	.603	38	25	2,157	359	573	108	9	101	345	238	21	522	40	12	2,440	1,002	218	3	21	14	49	.266	.341	.465	.806
5	Mets	71	2025	63	.619	39	24	2,090	280	511	105	13	74	271	230	41	483	49	8	2,387	864	192	3	23	14	55	.244	.328	.413	.741
6	Rays	48	2025	63	.540	34	29	2,101	274	519	99	3	64	261	190	17	535	88	17	2,326	816	166	1	17	1	42	.247	.312	.388	.701
7	Giants	42	2025	63	.556	35	28	2,074	259	479	94	9	59	248	219	20	532	39	13	2,338	768	162	11	14	5	42	.231	.309	.370	.679
8	Twins	37	2025	62	.548	34	28	2,084	262	502	98	7	62	250	179	41	511	33	12	2,319	800	167	1	14	4	40	.241	.311	.384	.695
9	Cardinals	26	2025	62	.548	34	28	2,106	291	542	114	4	56	276	204	30	481	36	12	2,365	832	174	6	19	10	47	.257	.329	.395	.724
10	Brewers	25	2025	63	.540	34	29	2,114	288	505	89	5	58	265	216	25	512	82	19	2,384	778	152	15	14	8	28	.239	.315	.368	.683
11	Reds	23	2025	63	.476	30	33	2,110	280	513	107	7	64	268	218	20	560	57	20	2,365	826	178	3	14	6	37	.243	.318	.391	.709
12	Astros	21	2025	62	.548	34	28	2,060	250	519	85	6	63	239	176	28	476	33	13	2,288	805	154	8	16	6	50	.252	.317	.391	.708
13	Phillies	18	2025	62	.597	37	25	2,117	291	538	94	9	67	276	225	22	489	56	11	2,384	851	170	5	15	6	37	.254	.330	.402	.732
14	Padres	16	2025	61	.574	35	26	2,030	253	505	88	8	54	233	187	15	427	46	13	2,265	771	150	15	18	6	38	.249	.314	.380	.694
15	Red Sox	13	2025	64	.469	30	34	2,228	303	565	120	8	75	291	217	26	588	56	13	2,489	926	203	5	13	13	32	.254	.325	.416	.741
16	Braves	6	2025	61	.443	27	34	2,069	250	506	87	6	66	240	209	18	523	36	12	2,313	803	159	6	11	5	38	.245	.318	.388	.706
17	Mariners	2	2025	61	.525	32	29	2,070	269	488	74	3	81	260	222	32	551	56	18	2,345	811	158	9	12	4	36	.236	.318	.392	.709
18	Blue Jays	-1	2025	62	.532	33	29	2,082	262	528	107	3	61	252	213	21	428	37	9	2,348	824	171	13	19	11	46	.254	.326	.396	.722
19	Rangers	-3	2025	63	.460	29	34	2,032	212	451	73	6	64	207	161	20	520	56	16	2,232	728	143	3	16	4	31	.222	.284	.358	.642
20	Royals	-3	2025	63	.524	33	30	2,120	216	531	106	12	39	213	149	21	434	51	22	2,326	778	157	14	22	10	29	.250	.303	.367	.670
21	Diamondbacks	-3	2025	62	.500	31	31	2,106	317	537	121	12	87	310	229	30	465	51	14	2,396	943	220	8	23	7	43	.255	.333	.448	.781
22	Guardians	-17	2025	61	.541	33	28	1,991	241	465	85	6	63	228	193	23	492	47	14	2,238	751	154	8	23	9	36	.234	.305	.377	.683
23	Nationals	-46	2025	62	.468	29	33	2,061	271	499	106	10	61	258	177	32	474	57	21	2,294	808	177	10	14	2	36	.242	.310	.392	.702
24	White Sox	-57	2025	63	.317	20	43	2,052	217	458	94	3	48	210	206	13	525	47	12	2,297	702	145	9	17	2	38	.223	.296	.342	.638
25	Angels	-57	2025	61	.459	28	33	2,030	255	459	86	7	88	246	157	25	591	25	10	2,233	823	181	6	15	6	37	.226	.288	.405	.693