The Cincinnati Reds have the highest run differential by a team in a game this season, with a differential of 22 runs against the Orioles on April 20.

Interpreted as:

highest run differential in one regular-season game this season

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Reds	22	4/20/2025	CIN	@	BAL	W 24-2	51	24	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
2	Padres	21	5/10/2025	SDP	@	COL	W 21-0	50	21	24	4	1	5	20	5	0	4	0	0	56	45	10	0	1	0	0	.480	.518	.900	1.418
3	Dodgers	17	5/15/2025	LAD	vs	ATH	W 19-2	40	19	18	2	0	5	19	8	0	6	2	0	50	35	7	0	2	0	0	.450	.520	.875	1.395
4	Dodgers	16	5/31/2025	LAD	vs	NYY	W 18-2	43	18	21	5	0	5	18	7	0	5	0	0	51	41	10	0	1	0	1	.488	.549	.953	1.503
5	Cubs	16	4/12/2025	CHC	@	LAD	W 16-0	47	16	21	5	0	4	16	4	1	4	1	0	53	38	9	0	1	0	0	.447	.491	.809	1.299
6	Rays	15	4/14/2025	TBR	vs	BOS	W 16-1	40	16	16	2	0	4	16	4	0	9	1	0	44	30	6	0	0	0	1	.400	.455	.750	1.205
7	Brewers	15	4/9/2025	MIL	@	COL	W 17-2	40	17	13	2	0	3	15	5	0	6	3	0	46	24	5	0	1	0	1	.325	.391	.600	.991
8	Cubs	15	3/31/2025	CHC	@	ATH	W 18-3	48	18	21	6	1	4	18	10	1	7	0	0	60	41	11	0	1	0	0	.438	.533	.854	1.388
9	Red Sox	14	5/23/2025	BOS	vs	BAL	W 19-5	45	19	20	6	0	3	19	8	0	7	0	0	53	35	9	0	0	0	1	.444	.528	.778	1.306
10	Blue Jays	14	5/21/2025	TOR	vs	SDP	W 14-0	40	14	14	3	0	2	13	3	2	7	1	0	46	23	5	1	0	0	0	.350	.422	.575	.997
11	Mets	14	4/28/2025	NYM	@	WSH	W 19-5	47	19	21	3	1	4	19	6	2	9	0	0	56	38	8	0	1	0	0	.447	.518	.809	1.326
12	Mariners	14	4/26/2025	SEA	vs	MIA	W 14-0	37	14	15	3	0	4	14	7	1	6	0	0	46	30	7	0	1	0	0	.405	.500	.811	1.311
13	Rangers	13	6/12/2025	TEX	@	MIN	W 16-3	43	16	16	1	0	6	16	9	1	5	1	0	53	35	7	0	0	0	0	.372	.491	.814	1.305
14	Rays	13	5/31/2025	TBR	@	HOU	W 16-3	44	16	18	7	0	5	16	4	0	12	1	0	48	40	12	0	0	1	0	.409	.458	.909	1.367
15	Rays	13	5/25/2025	TBR	vs	TOR	W 13-0	39	13	15	3	0	2	13	4	1	4	3	0	44	24	5	0	0	0	1	.385	.455	.615	1.070
16	Cubs	13	5/20/2025	CHC	@	MIA	W 14-1	46	14	21	4	0	2	14	2	0	7	0	0	49	31	6	0	1	0	1	.457	.469	.674	1.143
17	Dodgers	13	4/29/2025	LAD	vs	MIA	W 15-2	40	15	18	6	0	2	15	8	0	5	4	0	49	30	8	0	1	0	1	.450	.531	.750	1.281
18	Rangers	13	4/29/2025	TEX	vs	ATH	W 15-2	39	15	18	4	0	0	15	9	1	8	1	0	49	22	4	0	0	0	2	.462	.571	.564	1.136
19	Brewers	13	4/20/2025	MIL	vs	ATH	W 14-1	37	14	17	2	0	1	9	7	1	3	9	1	46	22	3	0	1	0	1	.459	.543	.595	1.138
20	Rangers	12	6/10/2025	TEX	@	MIN	W 16-4	45	16	18	4	0	2	16	4	1	4	2	0	51	28	6	0	1	0	0	.400	.451	.622	1.073
21	Reds	12	6/7/2025	CIN	vs	AZ	W 13-1	35	13	11	2	0	2	13	7	1	6	0	0	43	19	4	0	0	0	0	.314	.442	.543	.985
22	Tigers	12	6/2/2025	DET	@	CWS	W 13-1	42	13	16	2	1	5	13	4	0	7	1	0	46	35	8	0	0	0	0	.381	.435	.833	1.268
23	Blue Jays	12	5/29/2025	TOR	vs	ATH	W 12-0	41	12	18	3	0	4	12	5	0	3	1	0	47	33	7	0	1	0	0	.439	.489	.805	1.294
24	Yankees	12	5/24/2025	NYY	@	COL	W 13-1	43	13	21	6	1	1	12	5	0	8	1	0	50	32	8	0	2	1	4	.488	.520	.744	1.264
25	Tigers	12	5/12/2025	DET	vs	BOS	W 14-2	43	14	18	2	0	2	11	3	1	4	0	0	47	26	4	0	0	0	0	.419	.468	.605	1.073