The Chicago Cubs have the highest run differential by a team this season, with a differential of 115 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	115	2025	89	.596	53	36	3,079	481	789	155	18	135	471	310	23	694	104	18	3,446	1,385	308	7	27	10	36	.256	.326	.450	.776
2	Tigers	101	2025	90	.622	56	34	3,044	449	774	142	19	114	431	288	40	777	30	8	3,407	1,296	275	5	30	7	49	.254	.324	.426	.750
3	Yankees	93	2025	89	.539	48	41	3,029	456	770	155	14	138	436	357	36	793	62	20	3,455	1,367	307	4	29	28	60	.254	.337	.451	.788
4	Dodgers	81	2025	90	.622	56	34	3,076	499	802	150	15	141	481	335	32	734	49	14	3,476	1,405	306	3	30	18	62	.261	.337	.457	.793
5	Astros	67	2025	89	.607	54	35	2,996	391	781	130	10	99	372	259	41	683	47	20	3,329	1,228	239	9	24	8	73	.261	.326	.410	.735
6	Rays	67	2025	89	.539	48	41	3,004	424	779	138	9	100	403	269	28	737	117	28	3,335	1,235	247	8	26	8	62	.259	.323	.411	.735
7	Brewers	55	2025	89	.551	49	40	2,982	417	735	129	9	85	388	309	35	719	102	30	3,371	1,137	223	18	27	10	46	.246	.322	.381	.703
8	Phillies	53	2025	89	.584	52	37	3,023	410	774	139	13	96	391	305	33	703	77	16	3,390	1,227	248	9	20	10	54	.256	.329	.406	.735
9	Mets	46	2025	90	.578	52	38	2,997	398	734	142	13	118	389	309	55	703	68	10	3,395	1,256	273	5	29	15	73	.245	.324	.419	.743
10	Reds	34	2025	89	.517	46	43	2,990	414	741	147	11	95	393	297	29	774	66	23	3,346	1,195	253	7	23	7	59	.248	.320	.400	.719
11	Red Sox	31	2025	90	.500	45	45	3,113	442	787	180	14	109	422	298	41	826	76	19	3,480	1,322	303	7	21	16	48	.253	.324	.425	.749
12	Rangers	28	2025	89	.494	44	45	2,957	339	677	124	8	90	325	261	36	722	83	20	3,285	1,087	222	5	26	11	47	.229	.297	.368	.665
13	Giants	26	2025	90	.533	48	42	2,953	375	683	139	15	83	355	318	37	758	45	17	3,353	1,101	237	18	27	7	61	.231	.311	.373	.684
14	Cardinals	26	2025	90	.533	48	42	3,054	414	770	152	4	91	394	283	46	697	47	15	3,417	1,203	247	9	25	12	63	.252	.322	.394	.716
15	Mariners	21	2025	89	.528	47	42	3,059	401	757	125	4	118	388	304	48	779	81	23	3,448	1,244	247	15	22	15	57	.247	.323	.407	.730
16	Blue Jays	11	2025	89	.573	51	38	3,018	409	779	147	4	93	391	300	34	600	46	15	3,398	1,213	244	20	26	19	66	.258	.329	.402	.731
17	Padres	9	2025	88	.534	47	41	2,932	359	720	128	12	75	335	285	23	622	59	16	3,286	1,097	215	19	27	11	56	.246	.315	.374	.689
18	Braves	5	2025	88	.443	39	49	2,979	356	724	122	9	91	343	306	27	761	43	13	3,339	1,137	222	7	20	10	54	.243	.317	.382	.699
19	Diamondbacks	4	2025	89	.494	44	45	3,022	461	766	154	19	132	451	316	42	698	62	19	3,432	1,354	305	15	37	9	60	.253	.329	.448	.777
20	Twins	-16	2025	89	.483	43	46	2,976	369	712	137	8	100	356	258	53	739	45	16	3,307	1,165	245	2	18	5	58	.239	.310	.391	.701
21	Royals	-34	2025	90	.467	42	48	3,015	300	732	152	15	61	296	215	33	623	67	29	3,306	1,097	228	20	23	13	45	.243	.298	.364	.662
22	Pirates	-36	2025	90	.422	38	52	2,971	310	689	118	14	61	300	288	30	784	77	22	3,318	1,018	193	8	21	12	76	.232	.304	.343	.647
23	Angels	-48	2025	88	.489	43	45	2,946	377	671	117	10	128	363	250	49	862	39	19	3,272	1,192	255	8	19	13	52	.228	.297	.405	.702
24	Guardians	-54	2025	87	.460	40	47	2,830	310	635	119	8	85	295	270	29	714	66	22	3,168	1,025	212	11	28	13	51	.224	.296	.362	.658
25	Marlins	-69	2025	87	.460	40	47	2,982	369	757	145	15	78	355	262	19	702	69	27	3,301	1,166	238	16	22	7	49	.254	.316	.391	.707