Rickey Henderson has the most career runs, with 2,295 runs.

Interpreted as:

highest scoring starting by a player 5s in history

	NAME	R	GS	G	W	L	W%	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Rickey Henderson R. Henderson	2,295
2	Ty Cobb T. Cobb	2,244	0	3	0	0		3.60	0	0	0	1	5.0	6	2	0	2	0	2		20	0	0.00	3.60	0.00	0.00	0.0	10.0	1.60	.333	3.60	130	3.61	119	10.80	-0.3
3	Barry Bonds B. Bonds	2,227
4	Hank Aaron H. Aaron	2,174
5	Babe Ruth B. Ruth	2,174	147	163	94	46	.671	2.28	488	107	17	4	1221.1	974	309	10	441	29	12		4,896	25	3.60	3.25	1.11	0.07	10.0	9.0	1.16	.245	2.95	82	2.81	100	7.18	-6.6
6	Pete Rose P. Rose	2,165
7	Willie Mays W. Mays	2,062
8	Alex Rodriguez A. Rodriguez	2,021
9	Stan Musial S. Musial	1,949	0	1	0	0			0	0	0	0	0.0	0	0	0	0	0	0		1	0					0.0	0.0		.000
10	Derek Jeter D. Jeter	1,923
11	Albert Pujols A. Pujols	1,914	0	1	0	0		36.00	0	0	0	0	1.0	3	4	2	1	0	1	0	7	0	0.00	9.00	0.00	18.00	0.0	14.3	4.00	.250	36.00	917	32.11	822	27.00	-3.2
12	Lou Gehrig L. Gehrig	1,888
13	Tristram Speaker T. Speaker	1,882	0	1	0	0		9.00	0	0	0	0	1.0	2	1	0	0	0	1		4	0	0.00	0.00		0.00	0.0	0.0	2.00	.500	9.00	336	2.44	88	18.00	0
14	Mel Ott M. Ott	1,859
15	Craig Biggio C. Biggio	1,844
16	Frank Robinson F. Robinson	1,829
17	Eddie Collins E. Collins	1,821
18	Carl Yastrzemski C. Yastrzemski	1,816
19	Ted Williams T. Williams	1,798	0	1	0	0		4.50	1	0	0	0	2.0	3	1	0	0	0	1		9	0	4.50	0.00		0.00	11.1	0.0	1.50	.375	4.50	100	1.84	42	13.50	0.6
20	Paul Molitor P. Molitor	1,782
21	Charlie Gehringer C. Gehringer	1,775
22	Jimmie Foxx J. Foxx	1,751	2	10	1	0	1.000	1.52	11	0	0	0	23.2	13	4	0	14	1	8		97	0	4.18	5.32	0.79	0.00	11.3	14.4	1.14	.183	1.52	40	3.53	96	4.94	0.4
23	Honus Wagner H. Wagner	1,739	0	2	0	0		0.00	6	0	0	0	8.1	7	0	0	6	0	2		37	3	6.48	6.48	1.00	0.00	16.2	16.2	1.56	.280	5.40	0	3.44	103	7.56	-0.3
24	Cap Anson C. Anson	1,722	0	3	0	1	.000	4.50	1	0	0	1	4.0	4	2	2	2		3		21	0	2.25	4.50	0.50	4.50	4.8	9.5	1.50		11.25	143	10.76	306	9.00	-3
25	Jesse Burkett J. Burkett	1,720	14	23	3	11	.214	5.56	84	6	0	0	123.0	144	76	3	94	14	8		617	16	6.15	6.88	0.89	0.22	13.6	15.2	1.93	.334	9.44	156	4.53	119	10.54	-10