Between the 1997 and 2012 seasons, Alex Rodriguez hit the most homers, with 606 homers.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Alex Rodriguez A. Rodriguez	606	2,313	8,865	1,738	2,642	452	27	1,806	1,149	163	1,866	296	68	10,278	4,966	1,085	8	93	90	220	.298	.385	.560	.945	1880	623.9	.401	144	575.7
2	Jim Thome J. Thome	519	2,043	6,775	1,268	1,853	356	14	1,415	1,437	51	2,124	5	10	8,324	3,794	889	0	61	153	123	.274	.401	.560	.961	1556	531.7	.406	146	482.8
3	Albert Pujols A. Pujols	475	1,859	6,919	1,376	2,246	505	15	1,434	1,027	82	780	92	36	8,103	4,206	995	1	74	267	251	.325	.414	.608	1.022	1639	665.4	.425	164	652.2
4	Manny Ramirez M. Ramirez	472	1,900	6,867	1,309	2,168	453	16	1,547	1,125	101	1,517	20	20	8,165	4,069	941	0	72	198	203	.316	.416	.593	1.008	1640	632.2	.422	156	585.2
5	Vladimir Guerrero V. Guerrero	448	2,138	8,128	1,326	2,585	477	46	1,495	737	103	982	181	94	9,032	4,498	971	0	64	250	276	.318	.379	.553	.933	1574	467.5	.391	137	421.9
6	Sammy Sosa S. Sosa	438	1,428	5,434	972	1,534	248	16	1,144	697	29	1,453	57	37	6,216	3,128	702	0	56	121	134	.282	.364	.576	.939	1089	314.4	.391	135	286.7
7	Carlos Delgado C. Delgado	436	1,815	6,573	1,149	1,863	450	16	1,385	1,019	160	1,534	13	7	7,834	3,653	902	0	82	180	133	.283	.388	.556	.944	1402	429.9	.396	139	394.7
8	Andruw Jones A. Jones	429	2,165	7,493	1,193	1,910	376	35	1,276	884	97	1,719	149	59	8,551	3,643	840	6	71	69	191	.255	.338	.486	.825	1218	164.5	.353	111	125.2
9	Barry Bonds B. Bonds	428	1,403	4,310	1,106	1,340	268	26	1,003	1,476	72	668	134	31	5,893	2,944	722	1	34	462	83	.311	.490	.683	1.173	1431	696.9	.470	190	688.4
10	Paul Konerko P. Konerko	422	2,142	7,718	1,106	2,183	386	8	1,336	866	96	1,266	9	4	8,761	3,851	816	1	80	78	263	.283	.359	.499	.858	1354	288.8	.368	122	233.7
11	Chipper Jones C. Jones	415	2,194	7,859	1,416	2,400	494	30	1,427	1,351	18	1,221	128	41	9,315	4,199	939	1	86	176	229	.305	.405	.534	.939	1689	548.5	.399	143	514.5
12	Adam Dunn A. Dunn	406	1,721	5,929	988	1,422	301	10	1,018	1,170	76	2,031	61	23	7,210	2,961	717	2	33	110	93	.240	.370	.499	.870	1146	280.2	.372	125	227.6
13	Jason Giambi J. Giambi	403	1,969	6,309	1,092	1,767	348	8	1,301	1,255	167	1,378	18	9	7,814	3,340	759	0	83	92	136	.280	.408	.529	.938	1437	472.8	.402	145	448.4
14	David Ortiz D. Ortiz	401	1,832	6,539	1,124	1,863	482	16	1,326	1,011	32	1,386	11	8	7,649	3,580	899	2	65	129	159	.285	.380	.547	.928	1335	408	.392	137	352.4
15	Ken Griffey Jr. K. Griffey Jr.	392	1,614	5,816	967	1,577	297	17	1,111	808	56	1,145	76	25	6,746	3,084	706	2	64	127	124	.271	.362	.530	.892	1089	251.9	.376	124	213
16	Alfonso Soriano A. Soriano	372	1,757	6,943	1,046	1,897	434	30	1,035	454	79	1,576	270	75	7,531	3,507	836	9	46	64	109	.273	.323	.505	.828	1064	156.9	.351	112	111.1
17	Lance Berkman L. Berkman	360	1,806	6,235	1,119	1,843	412	29	1,200	1,163	66	1,248	86	48	7,519	3,393	801	1	54	157	140	.296	.409	.544	.953	1392	477.7	.404	146	435.7
18	Carlos Lee C. Lee	358	2,099	7,983	1,125	2,273	469	19	1,363	655	47	984	125	47	8,786	3,854	846	3	98	60	206	.285	.339	.483	.821	1241	173.5	.351	112	134
19	Todd Helton T. Helton	354	2,123	7,565	1,360	2,420	570	36	1,345	1,295	57	1,088	37	29	9,008	4,124	960	3	88	184	182	.320	.419	.545	.964	1713	609.6	.409	134	396
20	Gary Sheffield G. Sheffield	350	1,685	6,002	1,119	1,752	295	14	1,126	1,035	90	810	141	52	7,193	3,125	659	0	66	79	153	.292	.400	.521	.921	1282	390.9	.395	142	388.1
21	Adrian Beltre A. Beltre	346	2,115	7,965	1,089	2,227	463	30	1,215	579	68	1,301	115	40	8,697	3,788	839	14	71	73	199	.280	.331	.476	.807	1181	122.5	.345	111	118.9
22	Aramis Ramirez A. Ramirez	342	1,832	6,863	965	1,959	423	22	1,227	545	101	1,040	25	17	7,588	3,452	787	3	76	53	184	.285	.343	.503	.846	1134	216.8	.361	117	156.7
23	Mark Teixeira M. Teixeira	338	1,497	5,664	938	1,580	355	18	1,101	746	96	1,123	21	6	6,558	2,985	711	0	52	79	130	.279	.369	.527	.896	1089	303.8	.382	131	254.3
24	Rafael Palmeiro R. Palmeiro	336	1,369	4,989	795	1,384	249	9	987	764	44	711	29	16	5,857	2,659	594	0	60	98	104	.277	.374	.533	.907	986	256.8	.383	129	221.9
25	Carlos Beltran C. Beltran	334	1,919	7,314	1,267	2,064	416	74	1,243	896	39	1,337	306	47	8,349	3,630	824	17	83	92	140	.282	.360	.496	.856	1277	259.1	.365	121	214.7