Johan Santana had a 93-44 record with an ERA of 3.22, 1,381 strikeouts and 1 save in 251 appearances for the Twins in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Santana | 2000 |  MIN | 30 | 2 | 3 | .400 | 5 | 6.49 | 64 | 0 | 0 | 0 | 86.0 | 102 | 62 | 64 | 11 | 54 | 2 | 9 | 0 | 398 | 5 | 6.70 | 5.65 | 1.19 | 1.15 | 16.1 | 13.6 | 1.81 | .341 | 6.70 | 130 | 5.25 | 111 | 10.67 | -5.2 |
| 2 | | J. Santana | 2001 | MIN | 15 | 1 | 0 | 1.000 | 4 | 4.74 | 28 | 0 | 0 | 0 | 43.2 | 50 | 23 | 25 | 6 | 16 | 3 | 5 | 0 | 195 | 3 | 5.77 | 3.30 | 1.75 | 1.24 | 14.4 | 8.2 | 1.51 | .310 | 5.15 | 104 | 4.85 | 112 | 10.31 | -2.6 |
| 3 | | J. Santana | 2002 | MIN | 27 | 8 | 6 | .571 | 14 | 2.99 | 137 | 0 | 0 | 1 | 108.1 | 84 | 36 | 41 | 7 | 49 | 1 | 2 | 0 | 452 | 15 | 11.38 | 4.07 | 2.80 | 0.58 | 30.3 | 10.8 | 1.23 | .298 | 3.41 | 66 | 2.65 | 62 | 6.98 | 19.8 |
| 4 | | J. Santana | 2003 | MIN | 45 | 12 | 3 | .800 | 18 | 3.07 | 169 | 0 | 0 | 0 | 158.1 | 127 | 54 | 56 | 17 | 47 | 3 | 7 | 1 | 644 | 6 | 9.61 | 2.67 | 3.60 | 0.97 | 26.2 | 7.3 | 1.10 | .270 | 3.18 | 67 | 3.23 | 75 | 7.22 | 19.6 |
| 5 | | J. Santana | 2004 | MIN | 34 | 20 | 6 | .769 | 34 | 2.61 | 265 | 1 | 1 | 0 | 228.0 | 156 | 66 | 70 | 24 | 54 | 9 | 0 | 0 | 881 | 7 | 10.46 | 2.13 | 4.91 | 0.95 | 30.1 | 6.1 | 0.92 | .250 | 2.76 | 56 | 2.91 | 66 | 6.16 | 38.1 |
| 6 | | J. Santana | 2005 | MIN | 33 | 16 | 7 | .696 | 33 | 2.87 | 238 | 3 | 2 | 0 | 231.2 | 180 | 74 | 77 | 22 | 45 | 1 | 0 | 1 | 910 | 8 | 9.25 | 1.75 | 5.29 | 0.85 | 26.2 | 4.9 | 0.97 | .262 | 2.99 | 67 | 2.79 | 66 | 6.99 | 37 |
| 7 | | J. Santana | 2006 | MIN | 34 | 19 | 6 | .760 | 34 | 2.77 | 245 | 1 | 0 | 0 | 233.2 | 186 | 72 | 79 | 24 | 47 | 4 | 0 | 0 | 923 | 4 | 9.44 | 1.81 | 5.21 | 0.92 | 26.5 | 5.1 | 1.00 | .269 | 3.04 | 62 | 3.03 | 69 | 7.16 | 35.7 |
| 8 | | J. Santana | 2007 | MIN | 33 | 15 | 13 | .536 | 33 | 3.33 | 235 | 1 | 1 | 0 | 219.0 | 183 | 81 | 88 | 33 | 52 | 4 | 0 | 0 | 878 | 7 | 9.66 | 2.14 | 4.52 | 1.36 | 26.8 | 5.9 | 1.07 | .271 | 3.62 | 75 | 3.81 | 89 | 7.52 | 12.1 |
| Total | 251 | 93 | 44 | .679 | 175 | 3.22 | 1,381 | 6 | 4 | 1 | 1308.2 | 1,068 | 468 | 500 | 144 | 364 | 27 | 23 | 2 | 5,281 | 55 | 9.50 | 2.50 | 3.79 | 0.99 | 26.2 | 6.9 | 1.09 | .275 | 3.44 | 71 | 3.30 | 76 | 7.34 | 154.5 |
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