Johan Santana was 75-28 with an ERA of 2.83, 1,054 strikeouts and 1 save in 173 appearances between the 2002 and 2006 seasons.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Santana | 2002 |  MIN | 27 | 8 | 6 | .571 | 14 | 2.99 | 137 | 0 | 0 | 1 | 108.1 | 84 | 36 | 41 | 7 | 49 | 1 | 2 | 0 | 452 | 15 | 11.38 | 4.07 | 2.80 | 0.58 | 30.3 | 10.8 | 1.23 | .298 | 3.41 | 66 | 2.65 | 62 | 6.98 | 19.8 |
| 2 | | J. Santana | 2003 | MIN | 45 | 12 | 3 | .800 | 18 | 3.07 | 169 | 0 | 0 | 0 | 158.1 | 127 | 54 | 56 | 17 | 47 | 3 | 7 | 1 | 644 | 6 | 9.61 | 2.67 | 3.60 | 0.97 | 26.2 | 7.3 | 1.10 | .270 | 3.18 | 67 | 3.23 | 75 | 7.22 | 19.6 |
| 3 | | J. Santana | 2004 | MIN | 34 | 20 | 6 | .769 | 34 | 2.61 | 265 | 1 | 1 | 0 | 228.0 | 156 | 66 | 70 | 24 | 54 | 9 | 0 | 0 | 881 | 7 | 10.46 | 2.13 | 4.91 | 0.95 | 30.1 | 6.1 | 0.92 | .250 | 2.76 | 56 | 2.91 | 66 | 6.16 | 38.1 |
| 4 | | J. Santana | 2005 | MIN | 33 | 16 | 7 | .696 | 33 | 2.87 | 238 | 3 | 2 | 0 | 231.2 | 180 | 74 | 77 | 22 | 45 | 1 | 0 | 1 | 910 | 8 | 9.25 | 1.75 | 5.29 | 0.85 | 26.2 | 4.9 | 0.97 | .262 | 2.99 | 67 | 2.79 | 66 | 6.99 | 37 |
| 5 | | J. Santana | 2006 | MIN | 34 | 19 | 6 | .760 | 34 | 2.77 | 245 | 1 | 0 | 0 | 233.2 | 186 | 72 | 79 | 24 | 47 | 4 | 0 | 0 | 923 | 4 | 9.44 | 1.81 | 5.21 | 0.92 | 26.5 | 5.1 | 1.00 | .269 | 3.04 | 62 | 3.03 | 69 | 7.16 | 35.7 |
| Total | 173 | 75 | 28 | .728 | 133 | 2.83 | 1,054 | 5 | 3 | 1 | 960.0 | 733 | 302 | 323 | 94 | 242 | 18 | 9 | 2 | 3,810 | 40 | 9.88 | 2.27 | 4.36 | 0.88 | 27.7 | 6.4 | 1.02 | .266 | 3.03 | 63 | 2.93 | 68 | 6.87 | 150.3 |
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