Jon Lester had a 110-63 record with an ERA of 3.64 and 1,386 strikeouts in 242 appearances for the Red Sox in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Lester | 2006 |  BOS | 15 | 7 | 2 | .778 | 15 | 4.76 | 60 | 0 | 0 | 0 | 81.1 | 91 | 43 | 43 | 7 | 43 | 5 | 0 | 1 | 367 | 5 | 6.64 | 4.76 | 1.40 | 0.77 | 16.3 | 11.7 | 1.65 | .333 | 4.76 | 101 | 4.55 | 103 | 10.07 | -1.3 |
| 2 | | J. Lester | 2007 | BOS | 12 | 4 | 0 | 1.000 | 11 | 4.57 | 50 | 0 | 0 | 0 | 63.0 | 61 | 32 | 33 | 10 | 31 | 1 | 0 | 0 | 275 | 1 | 7.14 | 4.43 | 1.61 | 1.43 | 18.2 | 11.3 | 1.46 | .279 | 4.71 | 99 | 5.23 | 122 | 8.71 | -6.8 |
| 3 | | J. Lester | 2008 | BOS | 33 | 16 | 6 | .727 | 33 | 3.21 | 152 | 2 | 2 | 0 | 210.1 | 202 | 75 | 78 | 14 | 66 | 10 | 0 | 1 | 874 | 3 | 6.50 | 2.82 | 2.30 | 0.60 | 17.4 | 7.6 | 1.27 | .297 | 3.34 | 71 | 3.63 | 87 | 8.64 | 13.2 |
| 4 | | J. Lester | 2009 | BOS | 32 | 15 | 8 | .652 | 32 | 3.41 | 225 | 2 | 0 | 0 | 203.1 | 186 | 77 | 80 | 20 | 64 | 3 | 0 | 0 | 843 | 6 | 9.96 | 2.83 | 3.52 | 0.89 | 26.7 | 7.6 | 1.23 | .313 | 3.54 | 73 | 3.14 | 73 | 8.23 | 27 |
| 5 | | J. Lester | 2010 | BOS | 32 | 19 | 9 | .679 | 32 | 3.25 | 225 | 2 | 0 | 0 | 208.0 | 167 | 75 | 81 | 14 | 83 | 10 | 0 | 0 | 861 | 6 | 9.74 | 3.59 | 2.71 | 0.61 | 26.1 | 9.6 | 1.20 | .289 | 3.50 | 75 | 3.12 | 76 | 7.23 | 23.3 |
| 6 | | J. Lester | 2011 | BOS | 31 | 15 | 9 | .625 | 31 | 3.47 | 182 | 0 | 0 | 0 | 191.2 | 166 | 74 | 77 | 20 | 75 | 11 | 0 | 0 | 799 | 4 | 8.55 | 3.52 | 2.43 | 0.94 | 22.8 | 9.4 | 1.26 | .286 | 3.62 | 82 | 3.82 | 97 | 7.79 | 2.8 |
| 7 | | J. Lester | 2012 | BOS | 33 | 9 | 14 | .391 | 33 | 4.82 | 166 | 3 | 0 | 0 | 205.1 | 216 | 110 | 117 | 25 | 68 | 4 | 0 | 2 | 876 | 6 | 7.28 | 2.98 | 2.44 | 1.10 | 18.9 | 7.8 | 1.38 | .312 | 5.13 | 114 | 4.10 | 101 | 9.47 | -1.5 |
| 8 | | J. Lester | 2013 | BOS | 33 | 15 | 8 | .652 | 33 | 3.75 | 177 | 1 | 1 | 0 | 213.1 | 209 | 89 | 94 | 19 | 67 | 7 | 0 | 0 | 903 | 5 | 7.47 | 2.83 | 2.64 | 0.80 | 19.6 | 7.4 | 1.29 | .300 | 3.97 | 90 | 3.58 | 92 | 8.82 | 7.1 |
| 9 | | J. Lester | 2014 | BOS | 21 | 10 | 7 | .588 | 21 | 2.52 | 149 | 0 | 0 | 0 | 143.0 | 128 | 40 | 52 | 9 | 32 | 4 | 0 | 0 | 580 | 2 | 9.38 | 2.01 | 4.66 | 0.57 | 25.7 | 5.5 | 1.12 | .308 | 3.27 | 63 | 2.62 | 70 | 8.06 | 18.1 |
| Total | 242 | 110 | 63 | .636 | 241 | 3.64 | 1,386 | 10 | 3 | 0 | 1519.1 | 1,426 | 615 | 655 | 138 | 529 | 55 | 0 | 4 | 6,378 | 38 | 8.21 | 3.13 | 2.62 | 0.82 | 21.7 | 8.3 | 1.29 | .302 | 3.88 | 84 | 3.60 | 88 | 8.45 | 81.9 |
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