Jose Quintana has a 33-23 record with an ERA of 4.24 and 420 strikeouts in 82 appearances for the Cubs in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Quintana | 2017 |  CHC | 14 | 7 | 3 | .700 | 14 | 3.74 | 98 | 1 | 1 | 0 | 84.1 | 72 | 35 | 37 | 9 | 21 | 8 | 0 | 3 | 346 | 1 | 10.46 | 2.24 | 4.67 | 0.96 | 28.3 | 6.1 | 1.10 | .300 | 3.95 | 86 | 3.25 | 75 | 7.68 | 10 |
| 2 | | J. Quintana | 2018 | CHC | 32 | 13 | 11 | .542 | 32 | 4.03 | 158 | 0 | 0 | 0 | 174.1 | 162 | 78 | 81 | 25 | 68 | 3 | 0 | 3 | 739 | 3 | 8.16 | 3.51 | 2.32 | 1.29 | 21.4 | 9.2 | 1.32 | .282 | 4.18 | 101 | 4.43 | 110 | 8.36 | -8.1 |
| 3 | | J. Quintana | 2019 | CHC | 32 | 13 | 9 | .591 | 31 | 4.68 | 152 | 0 | 0 | 0 | 171.0 | 191 | 89 | 100 | 20 | 46 | 2 | 0 | 0 | 745 | 11 | 8.00 | 2.42 | 3.30 | 1.05 | 20.4 | 6.2 | 1.39 | .326 | 5.26 | 106 | 3.79 | 86 | 10.05 | 12.1 |
| 4 | | J. Quintana | 2020 | CHC | 4 | 0 | 0 | 1 | 4.50 | 12 | 0 | 0 | 0 | 10.0 | 10 | 5 | 5 | 1 | 3 | 0 | 0 | 0 | 41 | 1 | 10.80 | 2.70 | 4.00 | 0.90 | 29.3 | 7.3 | 1.30 | .360 | 4.50 | 102 | 2.98 | 68 | 9.00 | 1.6 | |
| Total | 82 | 33 | 23 | .589 | 78 | 4.24 | 420 | 1 | 1 | 0 | 439.2 | 435 | 207 | 223 | 55 | 138 | 13 | 0 | 6 | 1,871 | 16 | 8.60 | 2.82 | 3.04 | 1.13 | 22.4 | 7.4 | 1.30 | .305 | 4.56 | 100 | 3.92 | 93 | 8.90 | 15.7 |
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