The Cincinnati Reds had the highest run differential by a team in a game this season, with a differential of 22 runs versus the Orioles on April 20.

Interpreted as:

largest margin of victory in MLB regular-season game this season

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Reds	22	4/20/2025	CIN	@	BAL	W 24-2	51	24	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
2	Padres	21	5/10/2025	SDP	@	COL	W 21-0	50	21	24	4	1	5	20	5	0	4	0	0	56	45	10	0	1	0	0	.480	.518	.900	1.418
3	Royals	19	9/19/2025	KCR	vs	TOR	W 20-1	51	20	27	7	0	3	20	5	0	6	1	0	56	43	10	0	0	0	0	.529	.571	.843	1.415
4	Blue Jays	19	8/6/2025	TOR	@	COL	W 20-1	49	20	24	7	1	5	20	4	2	6	0	0	57	48	13	0	2	0	0	.490	.526	.980	1.506
5	Orioles	18	7/26/2025	BAL	vs	COL	W 18-0	40	18	18	4	0	3	16	6	1	4	1	0	47	31	7	0	0	0	3	.450	.532	.775	1.307
6	Rangers	17	8/27/2025	TEX	vs	LAA	W 20-3	46	20	22	5	0	4	20	4	2	6	0	0	53	39	9	0	1	0	0	.478	.528	.848	1.376
7	Astros	17	7/4/2025	HOU	@	LAD	W 18-1	44	18	20	6	0	5	17	8	1	8	0	1	54	41	11	0	1	1	1	.455	.537	.932	1.469
8	Dodgers	17	5/15/2025	LAD	vs	ATH	W 19-2	40	19	18	2	0	5	19	8	0	6	2	0	50	35	7	0	2	0	0	.450	.520	.875	1.395
9	Mariners	16	9/7/2025	SEA	@	ATL	W 18-2	45	18	19	1	1	5	14	3	2	7	2	0	51	37	7	0	1	0	1	.422	.471	.822	1.293
10	Dodgers	16	5/31/2025	LAD	vs	NYY	W 18-2	43	18	21	5	0	5	18	7	0	5	0	0	51	41	10	0	1	0	1	.488	.549	.953	1.503
11	Cubs	16	4/12/2025	CHC	@	LAD	W 16-0	47	16	21	5	0	4	16	4	1	4	1	0	53	38	9	0	1	0	0	.447	.491	.809	1.299
12	Phillies	15	8/28/2025	PHI	vs	ATL	W 19-4	44	19	20	3	1	7	19	4	0	3	0	0	48	46	11	0	0	0	0	.455	.500	1.045	1.545
13	Rays	15	4/14/2025	TBR	vs	BOS	W 16-1	40	16	16	2	0	4	16	4	0	9	1	0	44	30	6	0	0	0	1	.400	.455	.750	1.205
14	Brewers	15	4/9/2025	MIL	@	COL	W 17-2	40	17	13	2	0	3	15	5	0	6	3	0	46	24	5	0	1	0	1	.325	.391	.600	.991
15	Cubs	15	3/31/2025	CHC	@	ATH	W 18-3	48	18	21	6	1	4	18	10	1	7	0	0	60	41	11	0	1	0	0	.438	.533	.854	1.388
16	Brewers	14	8/12/2025	MIL	vs	PIT	W 14-0	40	14	15	4	0	5	14	5	0	8	0	0	46	34	9	0	1	0	0	.375	.435	.850	1.285
17	Blue Jays	14	8/4/2025	TOR	@	COL	W 15-1	50	15	25	4	1	3	15	3	0	5	0	0	53	40	8	0	0	0	2	.500	.528	.800	1.328
18	Red Sox	14	6/28/2025	BOS	vs	TOR	W 15-1	40	15	18	6	0	3	14	6	2	7	2	0	50	33	9	0	2	0	0	.450	.520	.825	1.345
19	Orioles	14	6/27/2025	BAL	vs	TBR	W 22-8	46	22	21	9	1	4	20	8	1	9	2	0	55	44	14	0	0	0	0	.457	.545	.957	1.502
20	Red Sox	14	5/23/2025	BOS	vs	BAL	W 19-5	45	19	20	6	0	3	19	8	0	7	0	0	53	35	9	0	0	0	1	.444	.528	.778	1.306
21	Blue Jays	14	5/21/2025	TOR	vs	SDP	W 14-0	40	14	14	3	0	2	13	3	2	7	1	0	46	23	5	1	0	0	0	.350	.422	.575	.997
22	Mets	14	4/28/2025	NYM	@	WSH	W 19-5	47	19	21	3	1	4	19	6	2	9	0	0	56	38	8	0	1	0	0	.447	.518	.809	1.326
23	Mariners	14	4/26/2025	SEA	vs	MIA	W 14-0	37	14	15	3	0	4	14	7	1	6	0	0	46	30	7	0	1	0	0	.405	.500	.811	1.311
24	Athletics	13	9/6/2025	ATH	@	LAA	W 17-4	49	17	21	4	0	4	17	6	1	8	1	0	56	37	8	0	0	0	0	.429	.500	.755	1.255
25	Red Sox	13	8/12/2025	BOS	@	HOU	W 14-1	40	14	13	2	0	3	14	8	2	5	2	0	51	24	5	0	1	0	0	.325	.451	.600	1.051