Nolan Ryan has the most career losses with >0 walks allowed, with 289 games.

Interpreted as:

largest regular-season loss in bb by a player bistory

	NAME	L	BB	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	289	2,795	308	.484	771	.516	746	3.25	5,498	218	59	3	5202.2	3,808	1,877	2,139	311	152	10	78	21,907	273	9.51	4.84	1.97	0.54	25.1	12.8	1.27	.266	3.70	6.59
2	Phil Niekro P. Niekro	236	1,809	271	.465	703	.535	629	3.45	2,913	207	38	10	4657.0	4,337	1,784	2,070	414	109	35	86	19,757	202	5.63	3.50	1.61	0.80	14.7	9.2	1.32	.270	4.00	8.38
3	Walter Johnson W. Johnson	230	1,374	308	.428	593	.572	539	1.77	2,736	429	83	11	4708.1	3,931		1,579	76	165	49			136	5.23	2.63	1.99	0.15		7.2	1.13	.262	3.02	7.51
4	Early Wynn E. Wynn	227	1,775	279	.449	612	.551	574	3.51	2,219	277	44	5	4305.1	3,993	1,678	1,912	315	56	31	36	18,339	51	4.64	3.71	1.25	0.66	12.1	9.7	1.34	.263	4.00	8.35
5	Steve Carlton S. Carlton	226	1,833	302	.428	667	.572	653	3.25	3,819	237	46	2	4799.2	4,271	1,733	1,964	369	47	6	150	20,047	166	7.16	3.44	2.08	0.69	19.1	9.1	1.27	.279	3.68	8.01
6	Gaylord Perry G. Perry	226	1,378	254	.471	621	.529	583	3.11	2,983	255	37	3	4502.0	4,119	1,555	1,799	321	89	11	163	18,629	141	5.96	2.75	2.16	0.64	16.0	7.4	1.22	.274	3.60	8.23
7	Bert Blyleven B. Blyleven	216	1,322	248	.466	592	.534	587	3.28	3,219	214	51	0	4301.1	3,941	1,567	1,736	365	126	2	71	17,821	96	6.74	2.77	2.43	0.76	18.1	7.4	1.22	.280	3.63	8.25
8	Bobo Newsom B. Newsom	211	1,734	202	.511	535	.489	464	4.01	1,995	240	31	11	3585.0	3,590	1,599	1,833	192	58	40		15,794	57	5.01	4.35	1.15	0.48	12.6	11.0	1.49	.288	4.60	9.01
9	Don Sutton D. Sutton	210	1,343	255	.452	623	.548	616	3.32	2,920	147	46	0	4308.0	3,773	1,589	1,738	377	69	4	103	17,808	91	6.10	2.81	2.17	0.79	16.4	7.5	1.19	.259	3.63	7.88
10	Frank Tanana F. Tanana	207	1,255	206	.501	547	.499	531	3.67	2,402	118	29	0	3618.0	3,479	1,474	1,658	386	104	5	116	15,348	109	5.98	3.12	1.91	0.96	15.7	8.2	1.31	.276	4.12	8.65
11	Warren Spahn W. Spahn	206	1,432	309	.400	601	.600	569	3.12	2,199	325	49	5	4451.2	4,072	1,545	1,734	357	36	24	59	18,465	70	4.45	2.90	1.54	0.72	11.9	7.8	1.24	.257	3.51	8.23
12	Red Ruffing R. Ruffing	206	1,542	250	.452	542	.548	498	3.86	1,838	309	39	6	3986.0	3,935	1,709	1,970	233	52	33		17,113	43	4.15	3.48	1.19	0.53	10.7	9.0	1.37	.275	4.45	8.88
13	Eppa Rixey E. Rixey	201	1,084	199	.502	502	.498	437	3.33	1,071	222	27	3	3493.0	3,599	1,291	1,622	72	66	44		14,792	81	2.76	2.79	0.99	0.19	7.2	7.3	1.34	.282	4.18	9.27
14	Ted Lyons T. Lyons	200	1,124	203	.496	462	.504	404	3.89	885	293	20	6	3438.2	3,750	1,488	1,791	181	26	41		14,927	49	2.32	2.94	0.79	0.47	5.9	7.5	1.42	.281	4.69	9.81
15	Tommy John T. John	196	1,259	227	.463	600	.537	572	3.42	1,807	129	35	1	3828.2	3,877	1,456	1,683	234	84	7	102	16,201	166	4.25	2.96	1.44	0.55	11.2	7.8	1.34	.284	3.96	9.11
16	Fergie Jenkins F. Jenkins	195	997	208	.484	503	.516	471	3.42	2,456	208	36	3	3536.1	3,251	1,344	1,499	384	69	15	117	14,658	56	6.25	2.54	2.46	0.98	16.8	6.8	1.20	.267	3.81	8.27
17	Sad Sam Jones S. Sam Jones	195	1,408	213	.478	535	.522	452	3.77	1,147	240	35	13	3576.1	3,718	1,499	1,823	138	64	56		15,476	68	2.89	3.54	0.81	0.35	7.4	9.1	1.43	.281	4.59	9.36
18	Jerry Koosman J. Koosman	190	1,198	198	.490	512	.510	475	3.41	2,305	124	28	4	3419.2	3,218	1,296	1,457	261	66	18	121	14,347	86	6.07	3.15	1.92	0.69	16.1	8.4	1.29	.281	3.83	8.47
19	Charlie Hough C. Hough	189	1,664	189	.500	660	.500	406	3.88	2,042	98	13	25	3303.2	2,876	1,425	1,629	333	148	127	44	14,286	168	5.56	4.53	1.23	0.91	14.3	11.6	1.37	.252	4.44	7.83
20	Burleigh Grimes B. Grimes	187	1,297	233	.445	501	.555	433	3.53	1,324	282	33	8	3646.2	3,810	1,432	1,792	125	89	53		15,808	84	3.27	3.20	1.02	0.31	8.4	8.2	1.40	.284	4.42	9.40
21	Tom Glavine T. Glavine	186	1,500	250	.427	589	.573	589	3.73	2,235	42	18	0	3774.0	3,710	1,563	1,711	307	64	0	145	16,152	59	5.33	3.58	1.49	0.73	13.8	9.3	1.38	.283	4.08	8.85
22	Jamie Moyer J. Moyer	186	1,155	208	.472	560	.528	534	4.45	1,997	23	2	0	3347.2	3,546	1,655	1,785	434	109	5	69	14,505	48	5.37	3.11	1.73	1.17	13.8	8.0	1.40	.288	4.80	9.53
23	Greg Maddux G. Maddux	185	999	212	.466	506	.534	504	3.45	2,284	69	16	0	3384.0	3,254	1,298	1,473	247	96	1	177	14,187	50	6.07	2.66	2.29	0.66	16.1	7.0	1.26	.285	3.92	8.65
24	Tom Seaver T. Seaver	184	1,390	268	.407	569	.593	566	2.90	3,211	195	46	0	4187.2	3,456	1,351	1,487	334	71	2	117	17,100	113	6.90	2.99	2.31	0.72	18.8	8.1	1.16	.258	3.20	7.43
25	Jim Kaat J. Kaat	182	1,083	210	.464	581	.536	481	3.60	1,853	130	22	4	3393.1	3,398	1,358	1,585	300	100	41	117	14,465	98	4.91	2.87	1.71	0.80	12.8	7.5	1.32	.278	4.20	9.01