largest margin of victory by nl baseball team in one game

The Cincinnati Reds had the highest run differential by an NL team in a game in 2025, with a differential of 22 runs versus the Orioles on April 20.

Interpreted as:

largest margin of victory by nl baseball team in one regular-season game this season

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Reds	22	4/20/2025	CIN	@	BAL	W 24-2	51	24	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
2	Padres	21	5/10/2025	SDP	@	COL	W 21-0	50	21	24	4	1	5	20	5	0	4	0	0	56	45	10	0	1	0	0	.480	.518	.900	1.418
3	Dodgers	17	5/15/2025	LAD	vs	ATH	W 19-2	40	19	18	2	0	5	19	8	0	6	2	0	50	35	7	0	2	0	0	.450	.520	.875	1.395
4	Dodgers	16	5/31/2025	LAD	vs	NYY	W 18-2	43	18	21	5	0	5	18	7	0	5	0	0	51	41	10	0	1	0	1	.488	.549	.953	1.503
5	Cubs	16	4/12/2025	CHC	@	LAD	W 16-0	47	16	21	5	0	4	16	4	1	4	1	0	53	38	9	0	1	0	0	.447	.491	.809	1.299
6	Phillies	15	8/28/2025	PHI	vs	ATL	W 19-4	44	19	20	3	1	7	19	4	0	3	0	0	48	46	11	0	0	0	0	.455	.500	1.045	1.545
7	Brewers	15	4/9/2025	MIL	@	COL	W 17-2	40	17	13	2	0	3	15	5	0	6	3	0	46	24	5	0	1	0	1	.325	.391	.600	.991
8	Cubs	15	3/31/2025	CHC	@	ATH	W 18-3	48	18	21	6	1	4	18	10	1	7	0	0	60	41	11	0	1	0	0	.438	.533	.854	1.388
9	Brewers	14	8/12/2025	MIL	vs	PIT	W 14-0	40	14	15	4	0	5	14	5	0	8	0	0	46	34	9	0	1	0	0	.375	.435	.850	1.285
10	Mets	14	4/28/2025	NYM	@	WSH	W 19-5	47	19	21	3	1	4	19	6	2	9	0	0	56	38	8	0	1	0	0	.447	.518	.809	1.326
11	Phillies	13	7/9/2025	PHI	@	SFG	W 13-0	42	13	17	4	0	2	13	3	1	9	2	0	48	27	6	0	2	0	0	.405	.438	.643	1.080
12	Phillies	13	6/27/2025	PHI	@	ATL	W 13-0	44	13	17	4	0	5	12	7	0	9	2	0	51	36	9	0	0	0	1	.386	.471	.818	1.289
13	Cubs	13	5/20/2025	CHC	@	MIA	W 14-1	46	14	21	4	0	2	14	2	0	7	0	0	49	31	6	0	1	0	1	.457	.469	.674	1.143
14	Dodgers	13	4/29/2025	LAD	vs	MIA	W 15-2	40	15	18	6	0	2	15	8	0	5	4	0	49	30	8	0	1	0	1	.450	.531	.750	1.281
15	Brewers	13	4/20/2025	MIL	vs	ATH	W 14-1	37	14	17	2	0	1	9	7	1	3	9	1	46	22	3	0	1	0	1	.459	.543	.595	1.138
16	Reds	12	6/7/2025	CIN	vs	AZ	W 13-1	35	13	11	2	0	2	13	7	1	6	0	0	43	19	4	0	0	0	0	.314	.442	.543	.985
17	Cubs	11	9/26/2025	CHC	vs	STL	W 12-1	36	12	12	1	1	4	12	3	1	7	1	0	40	27	6	0	0	0	0	.333	.400	.750	1.150
18	Pirates	11	9/21/2025	PIT	vs	ATH	W 11-0	37	11	15	5	0	2	11	4	0	8	0	0	41	26	7	0	0	0	1	.405	.463	.703	1.166
19	Giants	11	8/31/2025	SFG	vs	BAL	W 13-2	37	13	16	3	1	1	11	7	0	6	0	1	46	24	5	0	2	0	2	.432	.500	.649	1.149
20	Braves	11	8/27/2025	ATL	@	MIA	W 12-1	38	12	11	2	0	5	12	10	1	8	0	0	49	28	7	0	0	0	0	.289	.449	.737	1.186
21	Cubs	11	8/23/2025	CHC	@	LAA	W 12-1	39	12	14	4	0	3	12	3	1	6	0	0	44	27	7	0	1	0	1	.359	.409	.692	1.101
22	Brewers	11	8/3/2025	MIL	@	WSH	W 14-3	41	14	16	2	0	2	13	8	1	10	1	0	51	24	4	0	1	0	0	.390	.490	.585	1.076
23	Cubs	11	7/6/2025	CHC	vs	STL	W 11-0	37	11	13	3	1	1	10	5	1	6	2	0	44	21	5	0	1	0	0	.351	.432	.568	.999
24	Pirates	11	6/29/2025	PIT	vs	NYM	W 12-1	36	12	16	4	0	4	12	2	1	9	0	0	41	32	8	0	2	0	3	.444	.463	.889	1.352
25	Brewers	11	6/20/2025	MIL	@	MIN	W 17-6	41	17	19	4	0	0	17	6	0	10	1	2	49	23	4	0	2	0	0	.463	.510	.561	1.071