largest run differential by a team in a season with at least 80 loses

The San Diego Padres have the highest run differential by a team with 80+ losses in a season, with a differential of 104 runs in 2023.

	TEAM	DIFF	L	SEASON	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Padres	104	80	2023	82	.494	162	.506	5,401	752	1,317	273	14	205	719	653	57	1,311	137	32	6,177	2,233	492	22	44	16	134	.244	.329	.413	.743
2	Nationals	89	80	2018	82	.494	162	.506	5,517	771	1,402	284	25	191	737	631	59	1,289	119	33	6,288	2,309	500	41	40	56	104	.254	.335	.419	.753
3	Indians	88	84	2006	78	.519	162	.481	5,619	870	1,576	351	27	196	839	556	54	1,204	55	23	6,302	2,569	574	30	43	42	127	.280	.349	.457	.806
4	Red Sox	80	81	1985	81	.500	163	.500	5,720	800	1,615	292	31	162	760	562	30	816	66	27	6,419	2,455	485	50	57	39	164	.282	.347	.429	.776
5	Rockies	71	80	2000	82	.494	162	.506	5,660	968	1,664	320	53	161	905	601	42	907	131	61	6,453	2,573	534	75	75	64	126	.294	.362	.455	.816
6	Blue Jays	70	82	2005	80	.506	162	.494	5,581	775	1,480	307	39	136	735	486	89	955	72	35	6,233	2,273	482	21	56	18	126	.265	.331	.407	.738
7	Astros	63	82	1984	80	.506	162	.494	5,548	693	1,465	222	67	79	640	494	17	837	105	61	6,201	2,058	368	87	55	57	88	.264	.323	.371	.694
8	Orioles	62	85	1967	76	.528	161	.472	5,456	654	1,312	215	44	138	624	531	41	1,002	54	37	6,164	2,029	397	82	54	67	103	.240	.310	.372	.682
9	Twins	59	83	1964	79	.512	163	.488	5,610	737	1,413	227	46	221	707	553	44	1,019	46	22	6,318	2,395	494	74	37	43	120	.252	.322	.427	.749
10	White Sox	58	81	2002	81	.500	162	.500	5,502	856	1,475	289	29	217	819	555	49	952	75	31	6,207	2,473	535	48	53	17	111	.268	.338	.449	.787
11	Rangers	51	82	2006	80	.506	162	.494	5,659	835	1,571	357	23	183	799	505	40	1,061	53	24	6,272	2,523	563	18	50	35	148	.278	.338	.446	.784
12	Pirates	51	82	1968	80	.506	163	.494	5,569	583	1,404	180	44	80	538	422	33	953	130	59	6,163	1,912	304	96	43	93	133	.252	.306	.343	.650
13	Diamondbacks	49	80	2018	82	.494	162	.506	5,460	693	1,283	259	50	176	658	560	52	1,460	79	25	6,155	2,170	485	38	45	36	110	.235	.310	.397	.707
14	Giants	49	82	1932	72	.532	154	.468	5,530	755	1,527	263	54	116	718	348	23	391	31		5,950	2,246	433	49				.276	.322	.406	.728
15	Pirates	48	87	1984	75	.537	162	.463	5,537	615	1,412	237	33	98	586	438	19	841	96	62	6,119	2,009	368	81	44	47	131	.255	.310	.363	.672
16	Diamondbacks	46	81	2012	81	.500	162	.500	5,462	734	1,416	307	33	165	710	539	41	1,266	93	51	6,148	2,284	505	61	45	47	108	.259	.328	.418	.746
17	Twins	46	81	1973	81	.500	162	.500	5,625	738	1,521	240	44	120	688	598	34	954	87	46	6,331	2,209	404	34	40	49	150	.270	.342	.393	.735
18	Giants	45	81	1949	73	.526	156	.474	5,308	736	1,383	203	52	147	690	613	24	523	43		6,009	2,131	402	64			125	.261	.340	.401	.741
19	Indians	44	81	2008	81	.500	162	.500	5,543	805	1,455	339	22	171	772	560	103	1,213	77	29	6,298	2,351	532	43	49	44	123	.262	.339	.424	.763
20	Braves	44	83	2006	79	.512	162	.488	5,583	849	1,510	312	26	222	818	526	52	1,169	52	35	6,283	2,540	560	78	44	48	131	.270	.337	.455	.791
21	Dodgers	42	82	1964	80	.506	164	.494	5,499	614	1,375	180	39	79	555	438	19	893	141	60	6,120	1,870	298	120	44	55	105	.250	.305	.340	.645
22	Cardinals	40	81	1973	81	.500	162	.500	5,478	643	1,418	240	35	75	592	531	29	796	100	46	6,177	1,953	350	89	50	82	149	.259	.325	.357	.681
23	Twins	39	80	1979	82	.494	162	.506	5,544	764	1,544	256	46	112	714	526	31	693	66	45	6,296	2,228	414	142	53	37	116	.278	.341	.402	.743
24	Athletics	37	81	2010	81	.500	162	.500	5,448	663	1,396	276	30	109	619	527	47	1,061	156	38	6,116	2,059	415	43	51	16	129	.256	.324	.378	.702
25	Pirates	37	81	1915	73	.526	156	.474	5,113	557	1,259	197	91	24	464	419	49	656	182	111	5,743	1,710	312	162				.246	.309	.334	.644