Barry Bonds has hit the most career homers by a left-hander, with 762 home runs.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Barry Bonds B. Bonds	762	2,986	9,847	2,227	2,935	601	77	1,996	2,558	106	1,539	514	141	12,606	5,976	1,440	4	91	688	165	.298	.444	.607	1.051	2663	1,143.3	.435	172	1,142
2	Babe Ruth B. Ruth	714	2,503	8,399	2,174	2,873	506	136	2,214	2,062	43	1,330	123		10,617	5,793	1,356	113				.342	.474	.690	1.164	2727	1,436.8	.513	197	1,369.6
3	Ken Griffey Jr. K. Griffey Jr.	630	2,671	9,801	1,662	2,781	524	38	1,836	1,312	81	1,779	184	69	11,304	5,271	1,192	8	102	246	199	.284	.370	.538	.907	1892	521.1	.384	132	453.4
4	Jim Thome J. Thome	612	2,543	8,422	1,583	2,328	451	26	1,699	1,747	69	2,548	19	20	10,313	4,667	1,089	1	74	173	165	.276	.402	.554	.956	1925	653.9	.406	145	589.5
5	Rafael Palmeiro R. Palmeiro	569	2,831	10,472	1,663	3,020	585	38	1,835	1,353	87	1,348	97	40	12,046	5,388	1,192	15	119	172	232	.288	.371	.515	.885	1975	522.8	.380	130	453.5
6	Reggie Jackson R. Jackson	563	2,820	9,864	1,551	2,584	463	49	1,702	1,375	96	2,597	228	115	11,416	4,834	1,075	13	68	164	183	.262	.356	.490	.846	1749	503	.374	139	497.6
7	David Ortiz D. Ortiz	541	2,408	8,640	1,419	2,472	632	19	1,768	1,319	38	1,750	17	9	10,091	4,765	1,192	2	92	209	236	.286	.380	.552	.931	1760	559.9	.392	140	484.1
8	Willie McCovey W. McCovey	521	2,588	8,197	1,229	2,211	353	46	1,555	1,345	69	1,550	26	22	9,686	4,219	920	5	70	260	176	.270	.374	.515	.889	1594	551.5	.388	145	497.9
9	Ted Williams T. Williams	521	2,292	7,706	1,798	2,654	525	71	1,839	2,021	39	709	24	4	9,791	4,884	1,117	5	20	86	197	.344	.482	.634	1.116	2349	1,219.7	.493	188	1,067
10	Eddie Mathews E. Mathews	512	2,391	8,537	1,509	2,315	354	72	1,453	1,444	26	1,487	68	39	10,101	4,349	938	36	58	107	123	.271	.376	.509	.885	1685	557.5	.389	143	531.2
11	Mel Ott M. Ott	511	2,730	9,456	1,859	2,876	488	72	1,860	1,708	64	896	89		11,337	5,041	1,071	109			38	.304	.414	.533	.947	2204	826.4	.430	156	794.2
12	Fred McGriff F. McGriff	493	2,460	8,757	1,349	2,490	441	24	1,550	1,305	39	1,882	72	38	10,174	4,458	958	2	71	171	226	.284	.377	.509	.886	1678	454.1	.383	134	415.9
13	Lou Gehrig L. Gehrig	493	2,164	8,001	1,888	2,721	534	163	1,995	1,508	45	790	102		9,660	5,060	1,190	106			2	.340	.447	.632	1.080	2265	1,046.8	.477	173	980
14	Willie Stargell W. Stargell	475	2,360	7,927	1,194	2,232	423	55	1,540	937	78	1,936	17	16	9,026	4,190	953	9	75	227	143	.282	.360	.529	.889	1471	511.5	.387	145	459.3
15	Stan Musial S. Musial	475	3,026	10,972	1,949	3,630	725	177	1,951	1,599	53	696	78	31	12,712	6,134	1,377	35	53	127	243	.331	.417	.559	.976	2474	1,032.5	.435	158	896.7
16	Carlos Delgado C. Delgado	473	2,035	7,283	1,241	2,038	483	18	1,512	1,109	172	1,745	14	8	8,657	3,976	974	0	93	186	152	.280	.383	.546	.929	1513	435.7	.391	135	394
17	Adam Dunn A. Dunn	462	2,001	6,883	1,097	1,631	334	10	1,168	1,317	86	2,379	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
18	Carl Yastrzemski C. Yastrzemski	452	3,308	11,988	1,816	3,419	646	59	1,844	1,845	40	1,393	168	116	13,991	5,539	1,157	13	105	190	323	.285	.379	.462	.841	2155	643.2	.375	130	469.8
19	Jason Giambi J. Giambi	440	2,260	7,267	1,227	2,010	405	9	1,441	1,366	180	1,572	20	12	8,908	3,753	854	2	93	97	166	.277	.399	.516	.916	1579	480.6	.394	139	451
20	Billy Williams B. Williams	426	2,488	9,350	1,410	2,711	434	88	1,475	1,045	43	1,046	90	49	10,519	4,599	948	8	73	182	200	.290	.361	.492	.853	1630	511.5	.376	132	377.3
21	Darrell Evans D. Evans	414	2,687	8,973	1,344	2,223	329	36	1,354	1,605	35	1,410	98	68	10,737	3,866	779	34	90	141	133	.248	.361	.431	.792	1496	305.2	.355	120	251.8
22	Duke Snider D. Snider	407	2,143	7,161	1,259	2,116	358	85	1,333	971	21	1,237	99	50	8,237	3,865	850	52	32	104	166	.295	.380	.540	.919	1439	489.8	.404	139	398.8
23	Jim Edmonds J. Edmonds	393	2,011	6,858	1,251	1,949	437	25	1,199	998	49	1,729	67	50	7,980	3,615	855	10	65	91	122	.284	.376	.527	.903	1352	362.4	.385	132	326.3
24	Graig Nettles G. Nettles	390	2,700	8,986	1,193	2,225	328	28	1,314	1,088	50	1,209	32	36	10,226	3,779	746	12	90	94	197	.248	.329	.421	.750	1271	147.5	.337	111	126.5
25	Harold Baines H. Baines	384	2,830	9,908	1,299	2,866	488	49	1,628	1,062	14	1,441	34	34	11,092	4,604	921	9	99	187	298	.289	.356	.465	.820	1599	304.2	.358	118	249.9