
Between the 2004 and 2010 seasons, Johan Santana had the lowest ERA when pitching at least 750 innings, with an ERA of 2.87.
| NAME | ERA | IP | G | W | L | W% | GS | SO | CG | SHO | SV | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | J. Santana | 2.87 | 1512.1 | 222 | 110 | 57 | .659 | 222 | 1,479 | 13 | 8 | 0 | 1,246 | 483 | 522 | 162 | 362 | 27 | 0 | 11 | 6,074 | 38 | 8.80 | 2.15 | 4.09 | 0.96 | 24.3 | 6.0 | 1.06 | .268 | 3.11 | 67 | 3.31 | 78 | 7.42 | 158.3 | |
| 2 | A. Wainwright | 2.97 | 874.1 | 182 | 66 | 35 | .653 | 119 | 724 | 8 | 2 | 3 | 802 | 289 | 316 | 64 | 249 | 23 | 11 | 10 | 3,624 | 21 | 7.45 | 2.56 | 2.91 | 0.66 | 20.0 | 6.9 | 1.20 | .288 | 3.25 | 72 | 3.35 | 80 | 8.26 | 80 | |
| 3 | C. Carpenter | 2.98 | 1094.1 | 161 | 84 | 33 | .718 | 160 | 882 | 17 | 8 | 0 | 962 | 362 | 396 | 91 | 238 | 42 | 0 | 10 | 4,406 | 16 | 7.25 | 1.96 | 3.71 | 0.75 | 20.0 | 5.4 | 1.10 | .276 | 3.26 | 72 | 3.31 | 79 | 7.91 | 107.5 | |
| 4 | R. Halladay | 3.02 | 1455.2 | 202 | 110 | 55 | .667 | 201 | 1,107 | 44 | 14 | 0 | 1,383 | 489 | 532 | 122 | 243 | 39 | 0 | 15 | 5,860 | 22 | 6.84 | 1.50 | 4.56 | 0.75 | 18.9 | 4.1 | 1.12 | .290 | 3.29 | 68 | 3.26 | 74 | 8.55 | 181.3 | |
| 5 | T. Lincecum | 3.04 | 811.0 | 123 | 56 | 27 | .675 | 122 | 907 | 7 | 4 | 0 | 666 | 274 | 295 | 51 | 293 | 19 | 0 | 15 | 3,348 | 47 | 10.07 | 3.25 | 3.10 | 0.57 | 27.1 | 8.8 | 1.18 | .296 | 3.27 | 73 | 2.85 | 69 | 7.39 | 117.1 | |
| 6 | J. Peavy | 3.14 | 1177.1 | 183 | 84 | 56 | .600 | 183 | 1,213 | 8 | 4 | 0 | 988 | 411 | 432 | 105 | 360 | 41 | 0 | 26 | 4,819 | 22 | 9.27 | 2.75 | 3.37 | 0.80 | 25.2 | 7.5 | 1.14 | .285 | 3.30 | 78 | 3.23 | 76 | 7.55 | 135.3 | |
| 7 | F. Hernandez | 3.20 | 1154.2 | 172 | 71 | 53 | .573 | 172 | 1,042 | 13 | 4 | 0 | 1,057 | 410 | 465 | 97 | 357 | 35 | 0 | 14 | 4,787 | 60 | 8.12 | 2.78 | 2.92 | 0.76 | 21.8 | 7.5 | 1.22 | .295 | 3.62 | 76 | 3.42 | 80 | 8.24 | 109.1 | |
| 8 | R. Oswalt | 3.27 | 1513.0 | 232 | 107 | 66 | .618 | 228 | 1,206 | 17 | 7 | 0 | 1,461 | 549 | 583 | 128 | 352 | 55 | 1 | 26 | 6,247 | 19 | 7.17 | 2.09 | 3.43 | 0.76 | 19.3 | 5.6 | 1.20 | .296 | 3.47 | 77 | 3.41 | 78 | 8.69 | 158.3 | |
| 9 | B. Webb | 3.33 | 1139.0 | 170 | 77 | 53 | .592 | 170 | 893 | 14 | 7 | 0 | 1,060 | 422 | 492 | 80 | 367 | 37 | 0 | 30 | 4,765 | 47 | 7.06 | 2.90 | 2.43 | 0.63 | 18.7 | 7.7 | 1.25 | .289 | 3.89 | 73 | 3.52 | 78 | 8.38 | 124.3 | |
| 10 | CC Sabathia | 3.36 | 1539.0 | 226 | 114 | 63 | .644 | 226 | 1,326 | 26 | 10 | 0 | 1,410 | 575 | 632 | 133 | 415 | 52 | 0 | 22 | 6,318 | 27 | 7.75 | 2.43 | 3.20 | 0.78 | 21.0 | 6.6 | 1.19 | .291 | 3.70 | 76 | 3.41 | 78 | 8.25 | 161.6 | |
| 11 | B. Sheets | 3.40 | 958.2 | 148 | 57 | 53 | .518 | 148 | 869 | 15 | 3 | 0 | 890 | 362 | 399 | 105 | 195 | 10 | 0 | 9 | 3,915 | 33 | 8.16 | 1.83 | 4.46 | 0.99 | 22.2 | 5.0 | 1.13 | .287 | 3.75 | 80 | 3.35 | 77 | 8.36 | 107.3 | |
| 12 | J. Smoltz | 3.44 | 855.0 | 194 | 50 | 35 | .588 | 120 | 771 | 6 | 2 | 44 | 822 | 327 | 342 | 80 | 194 | 17 | 61 | 25 | 3,528 | 23 | 8.12 | 2.04 | 3.97 | 0.84 | 21.9 | 5.5 | 1.19 | .301 | 3.60 | 79 | 3.26 | 75 | 8.65 | 104.2 | |
| 13 | M. Cain | 3.45 | 1095.2 | 171 | 57 | 62 | .479 | 170 | 906 | 12 | 4 | 0 | 925 | 420 | 441 | 99 | 410 | 25 | 1 | 24 | 4,546 | 46 | 7.44 | 3.37 | 2.21 | 0.81 | 19.9 | 9.0 | 1.22 | .266 | 3.62 | 81 | 3.83 | 92 | 7.60 | 43.4 | |
| 14 | C. Zambrano | 3.48 | 1351.0 | 225 | 98 | 53 | .649 | 209 | 1,176 | 6 | 3 | 0 | 1,139 | 522 | 570 | 113 | 602 | 72 | 2 | 22 | 5,738 | 43 | 7.83 | 4.01 | 1.95 | 0.75 | 20.5 | 10.5 | 1.29 | .272 | 3.80 | 78 | 3.94 | 89 | 7.59 | 68.9 | |
| 15 | C. Hamels | 3.53 | 945.1 | 149 | 60 | 45 | .571 | 149 | 897 | 7 | 4 | 0 | 864 | 371 | 396 | 122 | 248 | 20 | 0 | 24 | 3,885 | 14 | 8.54 | 2.36 | 3.62 | 1.16 | 23.1 | 6.4 | 1.18 | .286 | 3.77 | 82 | 3.76 | 87 | 8.23 | 61.1 | |
| 16 | J. Weaver | 3.55 | 896.0 | 144 | 64 | 39 | .621 | 144 | 779 | 4 | 2 | 0 | 828 | 353 | 375 | 101 | 252 | 15 | 0 | 11 | 3,717 | 19 | 7.82 | 2.53 | 3.09 | 1.01 | 21.0 | 6.8 | 1.21 | .283 | 3.77 | 82 | 3.74 | 87 | 8.32 | 55.2 | |
| 17 | J. Lester | 3.55 | 766.0 | 124 | 61 | 25 | .709 | 123 | 712 | 6 | 2 | 0 | 707 | 302 | 315 | 65 | 287 | 29 | 0 | 2 | 3,220 | 21 | 8.37 | 3.37 | 2.48 | 0.76 | 22.1 | 8.9 | 1.30 | .302 | 3.70 | 78 | 3.59 | 85 | 8.31 | 55.4 | |
| 18 | R. Harden | 3.55 | 771.0 | 140 | 50 | 30 | .625 | 132 | 791 | 2 | 1 | 0 | 622 | 304 | 334 | 83 | 351 | 24 | 2 | 14 | 3,242 | 24 | 9.23 | 4.10 | 2.25 | 0.97 | 24.4 | 10.8 | 1.26 | .270 | 3.90 | 80 | 3.88 | 89 | 7.26 | 43.1 | |
| 19 | C. Billingsley | 3.55 | 825.2 | 160 | 59 | 41 | .590 | 131 | 751 | 3 | 2 | 0 | 760 | 326 | 351 | 61 | 357 | 31 | 7 | 26 | 3,525 | 38 | 8.19 | 3.89 | 2.10 | 0.66 | 21.3 | 10.1 | 1.35 | .301 | 3.83 | 87 | 3.67 | 87 | 8.28 | 49.4 | |
| 20 | T. Hudson | 3.56 | 1236.1 | 189 | 85 | 54 | .612 | 188 | 745 | 10 | 5 | 0 | 1,207 | 489 | 521 | 98 | 368 | 49 | 0 | 39 | 5,167 | 28 | 5.42 | 2.68 | 2.02 | 0.71 | 14.4 | 7.1 | 1.27 | .284 | 3.79 | 82 | 3.94 | 92 | 8.79 | 49.9 | |
| 21 | D. Haren | 3.58 | 1389.0 | 217 | 88 | 67 | .568 | 208 | 1,208 | 11 | 2 | 0 | 1,336 | 553 | 603 | 162 | 302 | 36 | 2 | 26 | 5,741 | 63 | 7.83 | 1.96 | 4.00 | 1.05 | 21.0 | 5.3 | 1.18 | .291 | 3.91 | 83 | 3.61 | 84 | 8.66 | 109.4 | |
| 22 | R. Dempster | 3.67 | 876.1 | 324 | 52 | 47 | .525 | 104 | 796 | 3 | 1 | 87 | 803 | 357 | 406 | 79 | 355 | 33 | 183 | 23 | 3,734 | 35 | 8.17 | 3.65 | 2.24 | 0.81 | 21.3 | 9.5 | 1.32 | .293 | 4.17 | 84 | 3.78 | 88 | 8.25 | 50.4 | |
| 23 | E. Bedard | 3.70 | 821.1 | 142 | 51 | 41 | .554 | 141 | 800 | 1 | 1 | 0 | 760 | 338 | 374 | 75 | 325 | 30 | 0 | 2 | 3,511 | 25 | 8.77 | 3.56 | 2.46 | 0.82 | 22.8 | 9.3 | 1.32 | .300 | 4.10 | 83 | 3.65 | 81 | 8.33 | 78.4 | |
| 24 | A. Pettitte | 3.79 | 1262.2 | 206 | 91 | 60 | .603 | 203 | 976 | 2 | 1 | 0 | 1,284 | 532 | 588 | 120 | 383 | 20 | 1 | 20 | 5,317 | 22 | 6.96 | 2.73 | 2.55 | 0.86 | 18.4 | 7.2 | 1.32 | .305 | 4.19 | 86 | 3.75 | 85 | 9.15 | 93.7 | |
| 25 | C. Young | 3.80 | 751.2 | 135 | 48 | 34 | .585 | 135 | 653 | 1 | 0 | 0 | 614 | 317 | 338 | 90 | 295 | 25 | 0 | 13 | 3,150 | 22 | 7.82 | 3.53 | 2.21 | 1.08 | 20.7 | 9.4 | 1.21 | .251 | 4.05 | 91 | 4.21 | 98 | 7.35 | 6.3 | |
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| NL East | W | L | PCT | GB |
|---|---|---|---|---|
61 | 43 | .587 | ||
56 | 49 | .533 | 5.5 | |
53 | 52 | .505 | 8.5 | |
52 | 53 | .495 | 9.5 | |
43 | 62 | .410 | 18.5 | |
| NL Central | W | L | PCT | GB |
65 | 39 | .625 | ||
59 | 45 | .567 | 6.0 | |
53 | 51 | .510 | 12.0 | |
53 | 52 | .505 | 12.5 | |
48 | 55 | .466 | 16.5 | |
| NL West | W | L | PCT | GB |
67 | 38 | .638 | ||
55 | 50 | .524 | 12.0 | |
52 | 53 | .495 | 15.0 | |
44 | 60 | .423 | 22.5 | |
42 | 64 | .396 | 25.5 |
| AL East | W | L | PCT | GB |
|---|---|---|---|---|
61 | 43 | .587 | ||
59 | 45 | .567 | 2.0 | |
53 | 50 | .515 | 7.5 | |
51 | 54 | .486 | 10.5 | |
48 | 57 | .457 | 13.5 | |
| AL Central | W | L | PCT | GB |
54 | 49 | .524 | ||
54 | 52 | .509 | 1.5 | |
52 | 54 | .491 | 3.5 | |
50 | 55 | .476 | 5.0 | |
44 | 62 | .415 | 11.5 | |
| AL West | W | L | PCT | GB |
53 | 51 | .510 | ||
52 | 54 | .491 | 2.0 | |
51 | 54 | .486 | 2.5 | |
44 | 60 | .423 | 9.0 | |
41 | 64 | .390 | 12.5 |