Since 1947, Mike Oquist has the lowest Game Score, with a Game Score of -21 against the Yankees on August 3, 1998.

Interpreted as:

lowest game score by a player since 1947

	NAME	GSc	DATE	TM		OPP	DEC	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Mike Oquist M. Oquist	-21	8/3/1998	OAK	vs	NYY	L	1	25.20	3	0	0	0	5.0	16	14	14	4	3	0	0	0	32	0
2	Ben Lively B. Lively	-16	8/1/2023	CIN	@	CHC	L	1	29.25	2	0	0	0	4.0	13	13	13	4	2	1	0	0	27	0
3	Luis Cessa L. Cessa	-16	4/16/2023	CIN	vs	PHI	L	1	33.00	0	0	0	0	3.0	14	11	11	1	3	1	0	0	27	1
4	Colby Lewis C. Lewis	-16	7/10/2014	TEX	vs	LAA	L	1	42.43	1	0	0	0	2.1	13	11	13	1	0	0	0	0	20	0
5	Scott Sanders S. Sanders	-15	4/14/1998	DET	@	TEX	L	1	24.75	2	0	0	0	4.0	16	11	11	0	3	0	0	1	29	1
6	Bradley Blalock B. Blalock	-14	5/10/2025	COL	vs	SDP	L	1	29.45	1	0	0	0	3.2	13	12	12	3	2	0	0	0	26	1
7	David Wells D. Wells	-14	8/20/1992	TOR	@	MIL	L	1	27.00	1	0	0	0	4.1	11	13	13	1	4	2	0	0	29	0
8	Galen Cisco G. Cisco	-14	7/27/1962	BOS	@	WSH	L	1	18.56	2	0	0	0	5.1	16	11	13	2	4	0	0	0	36	0
9	Kohei Arihara K. Arihara	-13	9/10/2022	TEX	vs	TOR	L	1	33.00	1	0	0	0	3.0	12	11	11	2	5	0	0	0	26	0
10	A.J. Burnett	-13	5/2/2012	PIT	@	STL	L	1	40.50	2	0	0	0	2.2	12	12	12	2	1	1	0	0	22	0
11	Bill Travers B. Travers	-13	8/14/1977	MIL	@	CLE	L	1	16.43	4	0	0	0	7.2	18	14	14	2	4	1	0	0	45	2
12	Edinson Volquez E. Volquez	-12	6/24/2016	KCR	vs	HOU	L	1	99.00	0	0	0	0	1.0	8	11	12	1	3	0	0	0	15	0
13	David Buchanan D. Buchanan	-12	8/11/2015	PHI	@	ARI	L	1	59.40	1	0	0	0	1.2	11	11	11	2	2	0	0	0	18	0
14	Yovani Gallardo Y. Gallardo	-12	8/8/2007	MIL	@	COL	L	1	37.13	1	0	0	0	2.2	12	11	11	2	3	0	0	1	23	0
15	Jerry Augustine J. Augustine	-12	5/11/1982	MIL	@	KCR	L	1	21.60	1	0	0	0	5.0	15	12	12	2	2	0	0	0	31	0
16	Jesús Luzardo J. Luzardo	-11	5/31/2025	PHI	vs	MIL	L	1	32.40	4	0	0	0	3.1	12	12	12	2	3	0	0	0	23	0
17	Masahiro Tanaka M. Tanaka	-11	7/25/2019	NYY	@	BOS	L	1	32.40	4	0	0	0	3.1	12	12	12	2	3	0	0	0	25	0
18	Derek Holland D. Holland	-11	5/5/2016	TEX	@	TOR	L	1	37.13	0	0	0	0	2.2	11	11	11	1	3	0	0	1	22	1
19	Chris Rusin C. Rusin	-11	8/22/2015	COL	vs	NYM	L	1	49.50	3	0	0	0	2.0	12	11	11	1	2	0	0	0	20	0
20	Jeremy Guthrie J. Guthrie	-11	5/25/2015	KCR	@	NYY	L	1	99.00	1	0	0	0	1.0	9	11	11	4	3	1	0	0	16	1
21	Jason Jennings J. Jennings	-11	7/29/2007	HOU	vs	SDP	L	1	148.50	0	0	0	0	0.2	8	11	11	2	3	0	0	0	13	0
22	Jon Garland J. Garland	-11	7/6/2007	CWS	vs	MIN	L	1	29.70	0	0	0	0	3.1	11	11	12	2	3	0	0	1	25	0
23	Jason Marquis J. Marquis	-11	6/21/2006	STL	@	CWS	L	1	23.40	3	0	0	0	5.0	14	13	13	4	1	0	0	0	30	0
24	Zack Greinke Z. Greinke	-11	6/10/2005	KCR	@	ARI		1	22.85	2	0	0	0	4.1	15	11	11	3	2	0	0	0	29	0
25	Bryan Rekar B. Rekar	-11	4/28/1996	COL	vs	MON	L	1	42.43	0	0	0	0	2.1	10	11	11	2	4	1	0	0	22	0