The Colorado Rockies have the lowest run differential by a team this season, with a differential of -145 runs.

Interpreted as:

lowest run differential this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	-145	2025	44	.159	7	37	1,445	138	308	64	11	36	137	125	16	432	20	8	1,600	502	111	4	10	4	32	.213	.281	.347	.629
2	Orioles	-75	2025	43	.349	15	28	1,411	159	324	57	6	49	150	124	21	381	24	9	1,569	540	112	1	12	2	34	.230	.299	.383	.682
3	Marlins	-66	2025	43	.395	17	26	1,471	182	364	69	6	40	174	134	12	377	39	14	1,637	565	115	9	11	5	20	.247	.313	.384	.697
4	Angels	-63	2025	43	.419	18	25	1,412	164	305	55	5	59	159	104	18	426	19	6	1,546	547	119	3	9	5	27	.216	.277	.387	.664
5	Athletics	-59	2025	45	.489	22	23	1,542	197	395	71	6	58	190	130	7	340	19	6	1,692	652	135	3	10	2	42	.256	.315	.423	.738
6	Nationals	-59	2025	46	.413	19	27	1,521	187	360	66	6	45	176	139	20	366	47	14	1,697	573	117	8	9	0	27	.237	.307	.377	.684
7	Pirates	-58	2025	45	.333	15	30	1,491	139	327	49	7	32	136	161	16	389	49	10	1,680	486	88	4	8	7	41	.219	.301	.326	.627
8	White Sox	-45	2025	45	.311	14	31	1,458	152	316	59	1	34	147	143	10	379	35	7	1,625	479	94	5	9	1	25	.217	.290	.329	.618
9	Blue Jays	-28	2025	44	.477	21	23	1,485	175	374	78	1	40	169	138	16	326	28	9	1,662	574	119	8	15	7	32	.252	.319	.387	.706
10	Guardians	-15	2025	44	.568	25	19	1,421	180	329	57	3	50	169	145	17	346	35	11	1,608	542	110	7	18	6	25	.232	.307	.381	.688
11	Rays	-9	2025	44	.455	20	24	1,475	174	360	62	3	39	166	135	9	377	51	12	1,634	545	104	0	15	0	32	.244	.308	.369	.678
12	Brewers	-3	2025	45	.467	21	24	1,487	193	344	59	4	37	174	150	19	369	58	14	1,676	522	100	10	10	6	24	.231	.308	.351	.659
13	Rangers	-2	2025	46	.522	24	22	1,485	158	339	57	4	48	155	115	16	356	36	10	1,629	548	109	2	11	2	26	.228	.289	.369	.658
14	Royals	-1	2025	46	.543	25	21	1,538	157	372	77	10	30	155	117	14	322	39	14	1,693	559	117	9	15	7	22	.242	.299	.363	.662
15	Diamondbacks	4	2025	45	.533	24	21	1,516	230	386	93	7	61	225	176	20	337	40	11	1,739	676	161	8	19	6	33	.255	.336	.446	.782
16	Braves	6	2025	45	.511	23	22	1,520	179	365	63	6	46	171	149	14	382	29	9	1,696	578	115	5	8	4	24	.240	.312	.380	.693
17	Red Sox	13	2025	46	.478	22	24	1,604	223	407	82	7	57	213	156	20	426	47	11	1,793	674	146	3	10	10	21	.254	.326	.420	.746
18	Mariners	15	2025	43	.558	24	19	1,455	206	349	56	2	59	198	171	24	381	45	13	1,668	586	117	8	10	3	26	.240	.328	.403	.730
19	Phillies	20	2025	44	.591	26	18	1,500	210	387	66	7	45	200	170	14	349	40	8	1,698	602	118	4	10	6	31	.258	.337	.401	.738
20	Astros	23	2025	44	.523	23	21	1,459	180	363	65	5	37	171	142	17	345	22	9	1,637	549	107	8	11	5	32	.249	.320	.376	.697
21	Reds	25	2025	46	.478	22	24	1,547	213	373	76	3	49	205	166	18	410	50	14	1,742	602	128	3	8	4	25	.241	.320	.389	.709
22	Twins	31	2025	45	.556	25	20	1,492	185	356	73	5	42	176	129	25	366	25	9	1,655	565	120	0	9	3	28	.239	.308	.379	.687
23	Cardinals	38	2025	45	.556	25	20	1,541	222	407	90	1	43	209	160	19	348	31	10	1,738	628	134	4	14	8	36	.264	.338	.408	.745
24	Giants	45	2025	45	.578	26	19	1,500	218	359	74	5	49	208	158	12	389	25	10	1,688	590	128	6	12	3	24	.239	.315	.393	.708
25	Padres	46	2025	43	.628	27	16	1,429	197	376	65	6	39	179	141	12	295	34	9	1,606	570	110	10	14	5	29	.263	.331	.399	.730