The Colorado Rockies have the lowest run differential by a team in losses this season, with a differential of -211 runs.

Interpreted as:

lowest run differential in losses this regular season

	TEAM	DIFF	L	SEASON	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	-211	50	2025	0	1.000	50	.000	1,640	128	327	61	11	39	126	136	14	496	23	9	1,804	527	111	5	9	4	37	.199	.265	.321	.586
2	Athletics	-198	38	2025	0	1.000	38	.000	1,266	121	290	52	2	42	119	130	8	313	22	3	1,412	472	96	2	6	3	43	.229	.304	.373	.676
3	Orioles	-167	36	2025	0	1.000	36	.000	1,207	97	261	51	3	27	87	90	16	344	22	6	1,322	399	81	0	9	1	27	.216	.278	.331	.608
4	White Sox	-144	42	2025	0	1.000	42	.000	1,363	87	272	51	2	25	81	120	8	367	23	10	1,501	402	78	3	7	0	30	.200	.267	.295	.562
5	Marlins	-141	35	2025	0	1.000	35	.000	1,200	105	277	48	3	24	103	102	7	290	12	10	1,320	403	75	6	5	0	24	.231	.294	.336	.630
6	Angels	-133	32	2025	0	1.000	32	.000	1,041	74	200	39	1	35	73	60	10	336	9	4	1,116	346	75	2	3	0	14	.192	.242	.332	.575
7	Pirates	-121	38	2025	0	1.000	38	.000	1,253	88	250	44	5	25	85	125	10	346	37	5	1,392	379	74	4	0	4	29	.200	.277	.302	.580
8	Nationals	-119	31	2025	0	1.000	31	.000	1,001	76	203	37	1	23	73	86	8	257	23	8	1,102	311	61	3	4	0	25	.203	.270	.311	.581
9	Brewers	-118	28	2025	0	1.000	28	.000	929	66	185	29	1	13	58	80	13	257	25	9	1,026	255	43	1	3	0	14	.199	.271	.274	.546
10	Guardians	-108	26	2025	0	1.000	26	.000	835	63	169	31	0	21	60	63	7	211	11	8	913	263	52	3	5	2	15	.202	.263	.315	.578
11	Red Sox	-107	33	2025	0	1.000	33	.000	1,129	91	239	44	4	23	88	90	16	344	27	3	1,243	360	71	2	6	6	16	.212	.278	.319	.597
12	Blue Jays	-107	28	2025	0	1.000	28	.000	919	69	191	45	1	20	67	98	9	230	16	4	1,034	298	66	3	5	5	26	.208	.289	.324	.613
13	Rangers	-99	31	2025	0	1.000	31	.000	1,001	53	188	30	4	18	52	63	8	277	25	9	1,079	280	52	2	5	0	11	.188	.240	.280	.520
14	Mariners	-97	26	2025	0	1.000	26	.000	870	72	175	22	2	23	68	91	17	241	28	9	983	270	47	2	3	2	16	.201	.288	.310	.599
15	Padres	-95	24	2025	0	1.000	24	.000	787	52	161	27	4	13	48	52	7	172	10	4	856	235	44	4	6	1	19	.205	.258	.299	.557
16	Reds	-95	32	2025	0	1.000	32	.000	1,054	76	206	45	4	15	72	89	7	307	27	11	1,155	304	64	1	4	0	16	.195	.262	.288	.550
17	Diamondbacks	-95	31	2025	0	1.000	31	.000	1,080	134	260	53	7	37	130	94	16	236	13	4	1,197	438	97	1	6	2	23	.241	.309	.406	.715
18	Royals	-94	29	2025	0	1.000	29	.000	951	53	191	37	7	10	50	67	11	230	14	9	1,039	272	54	4	6	3	14	.201	.260	.286	.546
19	Cardinals	-92	26	2025	0	1.000	26	.000	890	70	199	37	0	13	65	75	10	222	14	4	981	275	50	3	3	4	28	.224	.290	.309	.599
20	Astros	-89	27	2025	0	1.000	27	.000	895	69	193	30	1	20	65	71	10	224	10	3	984	285	51	3	5	1	18	.216	.279	.318	.598
21	Phillies	-86	23	2025	0	1.000	23	.000	789	68	172	27	3	15	67	78	7	203	15	3	876	250	45	0	2	3	12	.218	.293	.317	.610
22	Rays	-81	29	2025	0	1.000	29	.000	926	55	187	32	2	14	53	74	6	244	26	11	1,014	265	48	1	7	0	26	.202	.264	.286	.550
23	Twins	-79	27	2025	0	1.000	27	.000	880	54	170	37	3	13	52	65	17	236	14	6	968	252	53	0	6	0	16	.193	.260	.286	.547
24	Dodgers	-76	24	2025	0	1.000	24	.000	807	80	180	37	1	28	77	66	5	217	13	5	883	303	66	1	4	2	22	.223	.285	.375	.660
25	Cubs	-76	22	2025	0	1.000	22	.000	720	60	135	31	2	14	57	67	2	192	17	6	794	212	47	1	4	2	11	.188	.257	.294	.552