The Cincinnati Reds have the lowest run differential per game by a team in a season, with -5.25 in 1876.

	TEAM	DIFF/G	DIFF	G	SEASON	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Reds	-5.25	-341	65	1876	.138	9	56	2,372	238	555	51	12	4	132	41		136		2,413	642	67		.234		.271
2	Mountain City	-5.04	-126	25	1884	.240	6	19	899	90	223	30	6	2		22		130		921	271	38		.248		.301
3	Spiders	-4.69	-723	154	1899	.130	20	134	5,279	529	1,333	142	50	12	454	289	65	280	127	5,690	1,611	204	57	.253	.299	.305	.605
4	Alleghenys	-4.62	-638	138	1890	.169	23	113	4,739	597	1,088	160	43	20	426	408	66	460	208	5,213	1,394	223		.230	.300	.294	.594
5	Quakers	-4.55	-450	99	1883	.173	17	81	3,576	437	859	181	48	3	299	141		355		3,717	1,145	232		.240		.320
6	Quicksteps	-4.39	-79	18	1884	.111	2	16	521	35	91	8	8	2		22		123		543	121	18		.175		.232
7	Cowboys	-3.74	-307	82	1884	.203	16	63	2,802	311	557	104	15	6		123		529		2,925	709	125		.199		.253
8	Browns	-3.73	-496	133	1897	.221	29	102	4,673	592	1,285	151	67	32	496	354	76	314	172	5,183	1,666	250	80	.275	.336	.357	.693
9	Nationals	-3.7	-233	63	1884	.190	12	51	2,166	248	434	61	24	6		100	16	377		2,282	561	91		.200	.241	.259	.500
10	Saints	-3.67	-33	9	1884	.250	2	6	272	24	49	13	1	0		7		47		279	64	14		.180		.235
11	Reds	-3.34	-194	58	1877	.263	15	42	2,135	291	545	72	34	6	224	78		110		2,213	703	112		.255		.329
12	Colonels	-3.28	-459	140	1889	.196	27	111	4,955	632	1,249	170	75	22	503	320	41	521	203	5,316	1,635	267		.252	.303	.330	.633
13	Orioles	-3.26	-241	74	1882	.260	19	54	2,579	272	537	58	23	4		73		215		2,652	653	85		.208		.253
14	Ruby Legs	-3.25	-273	84	1882	.214	18	66	2,984	379	689	109	57	16	275	113		303		3,097	960	182		.231		.322
15	Bisons	-3.03	-406	134	1890	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160	5,432	1,617	264		.260	.347	.337	.684
16	Cowboys	-3	-378	126	1886	.248	30	91	4,236	494	967	177	48	19	370	269		608	96	4,505	1,297	244		.228		.306
17	Colonels	-2.95	-392	133	1895	.267	35	96	4,724	698	1,320	171	73	34	574	346	77	323	156	5,205	1,739	278	58	.279	.339	.368	.707
18	Alleghenys	-2.9	-319	110	1884	.278	30	78	3,689	406	777	105	50	2		143	41	411		3,873	988	157		.211	.248	.268	.516
19	Trojans	-2.88	-222	77	1879	.253	19	56	2,841	321	673	102	24	4	206	45		182		2,886	835	130		.237		.294
20	Spiders	-2.88	-383	133	1887	.298	39	92	4,649	729	1,170	178	77	14	562	375	46	486	355	5,070	1,544	269		.252	.314	.332	.646
21	Orioles	-2.82	-271	96	1883	.292	28	68	3,534	471	870	125	49	5		162		331		3,696	1,108	179		.246		.314
22	Nationals	-2.78	-347	125	1886	.233	28	92	4,082	445	856	135	51	23	331	265		582	143	4,347	1,162	209		.210		.285
23	Senators	-2.71	-376	139	1891	.326	44	91	4,715	691	1,183	147	84	19	536	468	76	485	219	5,259	1,555	250		.251	.328	.330	.658
24	Mutuals	-2.67	-152	57	1876	.375	21	35	2,180	260	494	39	15	2	161	18		35		2,198	569	56		.227		.261
25	Hoosiers	-2.66	-293	110	1884	.271	29	78	3,813	462	890	129	62	20		125	22	561		3,960	1,203	211		.233	.262	.315	.577