Since 1900, the Philadelphia Phillies have the lowest run differential by a team, with a differential of -6,219 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-6,219	19,507	.469	9,122	10,308	663,931	83,121	171,664	29,934	5,452	13,632	76,590	61,235	4,671	102,534	11,598	2,920	744,106	253,398	49,018	11,248	3,021	3,742	9,882	.259	.324	.382	.706
2	Orioles	-5,439	19,396	.475	9,155	10,131	658,830	83,756	169,991	29,385	4,915	14,477	77,440	63,390	4,493	98,657	10,580	2,788	740,357	252,637	48,777	10,533	3,111	2,580	10,867	.258	.326	.383	.709
3	Twins	-3,257	19,406	.482	9,299	9,998	662,001	85,334	173,591	29,810	6,335	12,067	78,571	62,472	5,183	94,764	12,028	3,084	743,019	252,272	48,212	10,191	3,172	2,665	10,995	.262	.329	.381	.710
4	Athletics	-3,152	19,360	.486	9,363	9,910	656,215	85,430	168,892	29,253	5,335	14,184	78,729	64,638	4,743	99,359	12,130	3,211	739,389	251,367	48,772	10,684	3,109	2,272	10,652	.257	.327	.383	.710
5	Padres	-2,853	8,928	.467	4,172	4,754	301,800	36,189	75,245	13,318	1,765	7,290	34,032	28,728	2,134	59,719	6,024	2,610	338,639	113,963	22,373	3,718	2,259	2,689	6,524	.249	.317	.378	.694
6	Marlins	-2,235	5,093	.459	2,339	2,754	173,145	21,439	44,122	8,398	988	4,636	20,330	15,651	1,840	38,551	3,276	1,303	193,647	68,404	14,022	1,724	1,287	1,203	3,822	.255	.321	.395	.716
7	Royals	-2,186	8,916	.476	4,247	4,667	304,948	38,949	80,064	14,971	2,295	7,030	36,763	26,077	2,470	52,353	7,114	2,909	338,548	120,715	24,296	2,377	2,676	1,873	6,800	.263	.323	.396	.719
8	Rangers	-2,064	10,209	.476	4,859	5,344	348,491	45,914	89,847	16,019	1,895	10,229	43,383	33,003	2,716	65,469	5,972	2,855	390,018	140,343	28,143	2,965	2,843	2,256	7,812	.258	.324	.403	.727
9	Rockies	-1,970	5,103	.458	2,339	2,764	175,240	25,202	47,303	9,345	1,320	5,764	23,967	16,073	1,594	38,069	3,076	1,377	196,277	76,580	16,429	2,006	1,364	1,209	3,892	.270	.334	.437	.771
10	Mariners	-1,648	7,633	.477	3,641	3,990	260,408	33,892	66,912	12,470	1,260	7,771	32,200	24,672	2,373	50,037	5,055	2,177	291,489	105,215	21,501	1,951	2,085	1,671	5,706	.257	.325	.404	.729
11	Braves	-1,541	19,533	.491	9,532	9,890	664,204	82,572	171,082	28,177	4,855	14,233	76,260	60,308	4,437	97,517	10,527	3,071	743,835	251,668	47,265	11,996	2,890	3,660	10,405	.258	.322	.379	.701
12	Nationals	-1,500	8,921	.482	4,299	4,618	301,721	37,379	76,551	14,774	1,792	7,640	35,136	28,349	2,642	57,427	6,572	2,790	338,892	117,829	24,206	3,885	2,295	2,885	6,524	.254	.321	.391	.712
13	Mets	-779	10,056	.484	4,864	5,184	340,216	41,493	85,001	15,183	1,819	8,634	39,078	32,529	2,882	65,251	5,915	2,739	382,246	129,724	25,636	3,989	2,630	3,145	7,487	.250	.318	.381	.700
14	Brewers	-757	8,925	.488	4,355	4,566	302,947	39,699	77,582	14,459	1,759	8,742	37,612	29,164	2,723	59,191	6,019	2,745	340,433	121,785	24,960	3,169	2,430	2,162	6,628	.256	.325	.402	.727
15	Angels	-704	10,221	.495	5,062	5,156	346,771	44,239	88,699	15,331	1,813	9,273	41,630	32,423	2,848	63,083	6,062	3,110	388,361	135,475	26,417	3,541	2,778	2,488	7,896	.256	.322	.391	.713
16	Reds	-643	19,565	.498	9,699	9,771	664,438	84,409	172,641	29,451	6,020	13,785	77,912	60,203	4,847	99,862	13,986	3,414	744,554	255,487	49,256	12,016	3,050	3,649	9,742	.260	.324	.385	.709
17	Rays	-399	4,353	.491	2,138	2,215	148,006	19,388	37,589	7,484	856	4,544	18,442	14,073	1,691	33,703	3,256	1,238	165,679	60,417	12,884	745	1,164	688	3,049	.254	.323	.408	.732
18	Diamondbacks	-281	4,354	.489	2,128	2,226	148,563	19,933	37,857	7,765	1,074	4,664	19,000	14,471	1,440	32,888	2,525	910	167,024	61,762	13,503	1,330	1,220	1,093	3,104	.255	.325	.416	.740
19	Terrapins	-193	314	.425	131	177	10,180	1,195	2,609	418	120	68	1,016	957	83	1,184	280		11,579	3,471	606	359				.256	.325	.341	.666
20	White Sox	-178	19,392	.499	9,621	9,668	656,564	84,193	170,433	28,266	5,556	12,314	77,392	62,213	5,254	92,389	13,643	3,492	739,637	246,753	46,136	12,375	3,231	2,464	10,542	.260	.327	.376	.703
21	Orioles	-122	276	.435	118	153	9,349	1,476	2,666	381	218	57	1,231	786	106	797	396		10,459	3,654	656	218				.285	.347	.391	.738
22	Packers	-43	307	.487	148	156	10,064	1,191	2,575	426	143	67	1,040	767	82	1,091	315		11,264	3,488	636	351				.256	.314	.347	.660
23	Blues	-42	308	.508	154	149	10,129	1,194	2,525	370	142	77	1,014	850	42	1,329	412		11,287	3,410	589	266				.249	.310	.337	.647
24	Tip-Tops	-41	310	.480	147	159	10,256	1,309	2,750	430	160	78	1,134	877	92	1,223	469		11,516	3,734	668	291				.268	.331	.364	.695
25	Terriers	-26	313	.489	149	156	10,223	1,199	2,598	392	146	49	1,026	1,079	70	1,150	308		11,783	3,429	587	411				.254	.329	.335	.665