The Philadelphia Phillies have the lowest run differential by a team in a game with more than 20 runs, with a differential of -3 runs versus the Cubs on August 25, 1922.
Interpreted as:
lowest run differential with more than 20 runs in regular-season game ever| TEAM | DIFF | R | DATE | TM | OPP | RESULT | AB | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Phillies | -3 | 23 | 8/25/1922 |  PHN | @ |  CHC | L 23-26 | 52 | 26 | 4 | 2 | 0 | 19 | 11 | 0 | 5 | 1 | 1 | 66 | 34 | 6 | 3 | .500 | .587 | .654 | 1.241 | |||
| 2 |  | Cubs | -1 | 22 | 5/17/1979 |  CHC | vs |  PHI | L 22-23 | 56 | 26 | 3 | 1 | 6 | 22 | 3 | 0 | 4 | 0 | 0 | 59 | 49 | 10 | 0 | 0 | 0 | 2 | .464 | .492 | .875 | 1.367 |
| 3 | Stars | -1 | 21 | 4/18/1890 | SYR | @ | BKA | L 21-22 | |||||||||||||||||||||||
| 4 |  | Phillies | 1 | 23 | 5/17/1979 | PHI | @ | CHC | W 23-22 | 53 | 24 | 7 | 1 | 5 | 23 | 12 | 1 | 7 | 2 | 0 | 68 | 48 | 13 | 0 | 2 | 4 | 0 | .453 | .544 | .906 | 1.450 |
| 5 | Gladiators | 1 | 22 | 4/18/1890 | BKA | vs | SYR | W 22-21 | |||||||||||||||||||||||
| 6 |  | Cubs | 3 | 26 | 8/25/1922 | CHC | vs | PHN | W 26-23 | 46 | 25 | 8 | 0 | 3 | 24 | 10 | 1 | 4 | 1 | 0 | 59 | 42 | 11 | 2 | .543 | .632 | .913 | 1.545 | |||
| 7 | | White Stockings | 4 | 21 | 7/28/1888 | CWS | vs | DET | W 21-17 | ||||||||||||||||||||||
| 8 | Spiders | 4 | 23 | 6/6/1888 | CLE | vs | LOU | W 23-19 | |||||||||||||||||||||||
| 9 | Brown Stockings | 4 | 21 | 7/6/1882 | STL | vs | LOU | W 21-17 | |||||||||||||||||||||||
| 10 |  | Orioles | 5 | 21 | 8/8/1896 |  BAL | @ |  WSH | W 21-16 | ||||||||||||||||||||||
| 11 | Kelly's Killers | 5 | 21 | 5/26/1891 | CNA | vs | BSA | W 21-16 | |||||||||||||||||||||||
| 12 |  | Grooms | 6 | 22 | 6/30/1893 |  BKN | @ |  PIT | W 22-16 | ||||||||||||||||||||||
| 13 |  | Reds | 6 | 23 | 8/7/1890 |  CIN | vs | PTN | W 23-17 | ||||||||||||||||||||||
| 14 |  | White Sox | 7 | 21 | 7/18/1936 |  CWS | @ |  PHA | W 21-14 | 45 | 20 | 9 | 0 | 1 | 19 | 11 | 1 | 3 | 0 | 0 | 59 | 32 | 10 | 2 | .444 | .561 | .711 | 1.273 | |||
| 15 |  | Indians | 7 | 21 | 4/14/1925 |  CLE | @ |  SLA | W 21-14 | 49 | 19 | 2 | 0 | 4 | 19 | 7 | 0 | 5 | 5 | 1 | 59 | 33 | 6 | 3 | .388 | .464 | .673 | 1.138 | |||
| 16 | | Grays | 7 | 21 | 6/25/1885 | BKN | vs |  PHA | W 21-14 | ||||||||||||||||||||||
| 17 |  | Red Sox | 8 | 22 | 6/29/1950 |  BSA | @ | PHA | W 22-14 | 47 | 19 | 4 | 1 | 1 | 21 | 11 | 1 | 5 | 1 | 0 | 60 | 28 | 6 | 1 | 0 | 1 | .404 | .525 | .596 | 1.121 | |
| 18 | | Orioles | 8 | 22 | 4/29/1891 | BAL | vs | WSH | W 22-14 | ||||||||||||||||||||||
| 19 | Reds | 8 | 21 | 8/1/1890 | BSP | @ | BUF | W 21-13 | |||||||||||||||||||||||
| 20 | Browns | 8 | 22 | 5/12/1887 | STL | vs |  BAL | W 22-14 | |||||||||||||||||||||||
| 21 |  | Athletics | 8 | 23 | 6/17/1876 |  PHI | vs | CIN | W 23-15 | ||||||||||||||||||||||
| 22 | | White Sox | 9 | 22 | 5/31/1970 | CWS | @ |  BOS | W 22-13 | 51 | 24 | 6 | 1 | 1 | 18 | 3 | 0 | 9 | 1 | 1 | 55 | 35 | 8 | 1 | 0 | 1 | 0 | .471 | .500 | .686 | 1.186 |
| 23 |  | Dodgers | 9 | 21 | 6/24/1950 |  BKN | vs | PIT | W 21-12 | 46 | 25 | 5 | 1 | 2 | 18 | 7 | 0 | 2 | 0 | 1 | 54 | 38 | 8 | 1 | 0 | 0 | .543 | .604 | .826 | 1.430 | |
| 24 |  | Giants | 9 | 21 | 6/20/1912 |  NYG | @ |  BSN | W 21-12 | 42 | 20 | 2 | 0 | 2 | 17 | 8 | 0 | 5 | 9 | 53 | 28 | 4 | 3 | .476 | .560 | .667 | 1.227 | ||||
| 25 |  | Giants | 9 | 23 | 9/2/1893 |  NYG | vs | LOU | W 23-14 | ||||||||||||||||||||||
Results may be incomplete. StatMuse has complete team, game-level data for runs going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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