The Colorado Rockies have the lowest run differential by a team this season, with a differential of -198 runs.

Interpreted as:

lowest run diffrerential team this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	-198	2025	65	.185	12	53	2,151	204	472	103	19	55	202	170	21	624	30	15	2,362	778	177	7	13	5	44	.219	.282	.362	.643
2	Athletics	-118	2025	68	.382	26	42	2,331	293	596	114	8	82	284	222	15	556	38	8	2,585	972	204	4	13	5	63	.256	.323	.417	.740
3	Marlins	-91	2025	64	.375	24	40	2,182	259	541	109	8	55	249	194	16	523	50	23	2,420	831	172	13	15	5	39	.248	.312	.381	.693
4	Orioles	-89	2025	64	.406	26	38	2,133	246	507	92	9	70	229	183	27	562	46	13	2,365	827	171	2	20	3	50	.238	.303	.388	.691
5	Pirates	-54	2025	67	.403	27	40	2,216	218	509	84	13	46	209	228	25	587	62	18	2,486	757	143	5	12	10	60	.230	.307	.342	.649
6	Angels	-52	2025	65	.477	31	34	2,158	277	488	91	7	94	267	164	29	631	30	11	2,373	875	192	6	16	6	37	.226	.288	.405	.693
7	White Sox	-51	2025	66	.333	22	44	2,145	233	478	99	3	52	223	219	13	551	47	13	2,405	739	154	10	18	2	38	.223	.296	.345	.641
8	Nationals	-51	2025	65	.462	30	35	2,149	275	514	107	10	63	262	180	33	496	57	23	2,386	830	180	10	14	2	39	.239	.306	.386	.692
9	Guardians	-22	2025	65	.523	34	31	2,120	254	496	89	6	67	240	210	25	530	52	15	2,388	798	162	9	24	10	39	.234	.307	.376	.684
10	Diamondbacks	-14	2025	66	.485	32	34	2,239	331	565	123	12	93	324	246	30	503	51	15	2,549	991	228	11	23	9	49	.252	.331	.443	.774
11	Royals	-9	2025	66	.515	34	32	2,223	226	562	110	12	44	223	156	22	456	53	23	2,438	828	166	15	22	10	35	.253	.305	.372	.678
12	Mariners	-4	2025	65	.508	33	32	2,222	286	533	81	4	84	277	232	33	587	63	18	2,510	874	169	10	13	5	38	.240	.319	.393	.713
13	Blue Jays	0	2025	66	.545	36	30	2,224	281	563	117	3	67	271	222	22	451	37	10	2,501	887	187	14	19	12	49	.253	.324	.399	.723
14	Rangers	2	2025	66	.470	31	35	2,133	221	472	77	6	66	215	168	21	543	58	16	2,341	759	149	3	16	4	33	.221	.283	.356	.639
15	Braves	9	2025	65	.431	28	37	2,207	266	537	91	6	71	256	226	22	558	36	12	2,474	853	168	7	12	7	39	.243	.318	.386	.705
16	Red Sox	15	2025	68	.471	32	36	2,380	338	607	131	9	83	324	239	32	629	59	14	2,670	1,005	223	5	14	14	35	.255	.329	.422	.752
17	Phillies	16	2025	66	.576	38	28	2,247	301	568	101	9	68	285	234	23	516	58	12	2,526	891	178	7	15	8	41	.253	.328	.397	.724
18	Padres	17	2025	65	.569	37	28	2,162	266	531	92	9	56	245	201	15	461	51	13	2,414	809	157	17	19	6	40	.246	.312	.374	.686
19	Brewers	17	2025	67	.522	35	32	2,232	293	526	90	5	59	270	235	27	546	85	20	2,525	803	154	15	16	8	31	.236	.314	.360	.674
20	Astros	23	2025	65	.554	36	29	2,164	261	542	87	6	65	249	185	29	496	38	13	2,402	836	158	8	16	6	52	.250	.316	.386	.702
21	Cardinals	27	2025	66	.545	36	30	2,240	305	576	120	4	59	290	213	31	513	37	13	2,512	881	183	8	20	10	49	.257	.327	.393	.721
22	Twins	37	2025	65	.538	35	30	2,184	276	528	102	7	67	264	195	42	536	33	12	2,437	845	176	1	15	4	42	.242	.314	.387	.701
23	Reds	41	2025	67	.507	34	33	2,249	308	555	113	7	73	296	235	21	589	58	21	2,526	901	193	6	15	6	39	.247	.322	.401	.722
24	Giants	45	2025	66	.576	38	28	2,164	271	496	98	9	61	257	225	21	558	41	14	2,438	795	168	11	17	5	42	.229	.306	.367	.673
25	Rays	50	2025	66	.545	36	30	2,209	297	546	106	3	70	282	200	19	558	93	17	2,452	868	179	4	20	3	42	.247	.313	.393	.705