The Philadelphia Phillies have the lowest run differential by a team, with a differential of -5,703 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-5,703	21,705	.474	10,243	11,347	742,679	96,385	193,389	33,430	6,679	14,203	86,606	67,780	5,418	105,418	14,971	2,916	830,812	282,786	54,312	11,917	3,018	3,739	9,867	.260	.326	.381	.706
2	Orioles	-5,454	19,370	.475	9,140	10,120	657,967	83,631	169,780	29,344	4,912	14,439	77,322	63,313	4,480	98,434	10,563	2,785	739,397	252,265	48,695	10,532	3,105	2,576	10,849	.258	.326	.383	.709
3	Twins	-3,214	19,379	.482	9,290	9,980	661,078	85,206	173,360	29,766	6,334	12,026	78,446	62,379	5,166	94,540	12,018	3,081	741,980	251,872	48,126	10,190	3,167	2,664	10,978	.262	.329	.381	.710
4	Athletics	-3,122	19,333	.486	9,352	9,894	655,309	85,323	168,677	29,216	5,333	14,152	78,625	64,547	4,735	99,117	12,112	3,207	738,377	251,015	48,701	10,682	3,104	2,272	10,632	.257	.327	.383	.710
5	Padres	-2,852	8,901	.467	4,159	4,740	300,903	36,082	75,031	13,277	1,761	7,270	33,929	28,640	2,126	59,527	6,009	2,605	337,631	113,640	22,308	3,712	2,250	2,687	6,505	.249	.317	.378	.694
6	Marlins	-2,234	5,067	.459	2,325	2,742	172,239	21,321	43,880	8,347	984	4,615	20,215	15,580	1,836	38,347	3,258	1,296	192,653	68,040	13,946	1,720	1,278	1,203	3,807	.255	.321	.395	.716
7	Royals	-2,164	8,891	.477	4,238	4,651	304,109	38,866	79,862	14,929	2,292	7,006	36,681	26,018	2,464	52,196	7,097	2,900	337,637	120,393	24,227	2,372	2,674	1,869	6,783	.263	.323	.396	.719
8	Rangers	-2,084	10,184	.476	4,846	5,332	347,630	45,806	89,645	15,972	1,893	10,206	43,282	32,915	2,703	65,260	5,954	2,849	389,044	140,021	28,071	2,963	2,833	2,251	7,798	.258	.324	.403	.727
9	Rockies	-1,925	5,077	.459	2,330	2,747	174,354	25,090	47,086	9,297	1,310	5,733	23,859	16,006	1,583	37,812	3,060	1,370	195,306	76,202	16,340	2,005	1,358	1,209	3,868	.270	.335	.437	.772
10	Colonels	-1,890	2,355	.429	993	1,320	82,256	12,464	21,505	2,816	1,292	436	8,508	6,080	757	3,638	3,474		89,787	28,213	4,544	609				.261	.319	.343	.662
11	Senators	-1,865	1,265	.366	454	788	43,645	6,912	11,886	1,615	787	357	5,764	4,269	575	3,492	1,975		48,963	16,146	2,759	474				.272	.345	.370	.715
12	Mariners	-1,653	7,607	.477	3,629	3,976	259,491	33,774	66,668	12,425	1,259	7,741	32,086	24,601	2,357	49,813	5,029	2,172	290,472	104,834	21,425	1,947	2,076	1,664	5,685	.257	.324	.404	.728
13	Nationals	-1,468	8,895	.483	4,292	4,599	300,840	37,273	76,334	14,730	1,791	7,615	35,033	28,282	2,630	57,245	6,554	2,779	337,920	117,491	24,136	3,880	2,288	2,882	6,509	.254	.321	.391	.712
14	Nationals	-1,080	514	.326	163	337	17,337	2,160	3,944	533	220	125	1,647	1,246	127		1,040		18,710	5,292	878					.227	.284	.305	.589
15	Brewers	-809	8,900	.488	4,338	4,558	302,104	39,557	77,343	14,417	1,756	8,715	37,477	29,081	2,714	59,004	6,001	2,734	339,481	121,417	24,888	3,165	2,417	2,160	6,612	.256	.325	.402	.726
16	Orioles	-802	944	.437	403	519	32,654	4,964	7,699	1,083	504	136	2,635	2,289	208		1,451		35,293	10,198	1,723					.236	.293	.312	.605
17	Mets	-770	10,029	.484	4,851	5,170	339,294	41,373	84,777	15,148	1,818	8,587	38,958	32,443	2,868	65,027	5,893	2,737	381,218	129,322	25,553	3,989	2,624	3,143	7,467	.250	.318	.381	.699
18	Angels	-711	10,195	.495	5,047	5,145	345,897	44,112	88,496	15,302	1,811	9,229	41,508	32,341	2,827	62,834	6,049	3,102	387,378	135,107	26,342	3,539	2,774	2,484	7,880	.256	.322	.391	.713
19	Spiders	-672	1,802	.469	827	938	63,232	10,057	17,006	2,308	961	292	8,238	5,871	580	3,144	2,800		70,233	22,112	3,561	550				.269	.337	.350	.686
20	Reds	-638	348	.365	125	217	12,768	1,643	3,191	408	157	30		318					13,086	4,003	595					.250		.314
21	Hoosiers	-540	398	.370	146	249	13,870	2,050	3,536	570	138	129	1,577	913	131		936		14,914	4,769	837					.255	.307	.344	.651
22	Cowboys	-496	271	.364	98	171	9,535	1,431	2,256	304	137	37	1,052	718	123		729		10,376	2,945	478					.237	.298	.309	.607
23	Rays	-445	4,327	.490	2,120	2,207	147,101	19,226	37,325	7,439	850	4,507	18,291	13,990	1,679	33,485	3,230	1,229	164,666	59,985	12,796	738	1,158	685	3,031	.254	.323	.408	.731
24	Bisons	-406	134	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160		5,432	1,617	264					.260	.347	.337	.684
25	Trojans	-388	330	.412	134	191	11,951	1,542	2,929	456	151	26		414					12,365	3,765	633					.245		.315