Between the 2000 and 2009 seasons, Felix Hernandez fanned the most hitters for the Mariners, with 810 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Felix Hernandez F. Hernandez	810	138	58	41	.586	138	3.45	7	3	0	905.0	863	347	385	80	287	27	0	13	3,786	46	8.06	2.85	2.82	0.80	21.4	7.6	1.27	.303	3.83	80	3.53	82	8.58	80.6
2	Jamie Moyer J. Moyer	802	217	93	63	.596	216	4.11	10	3	0	1371.1	1,378	627	670	185	372	52	1	21	5,798	15	5.26	2.44	2.16	1.21	13.8	6.4	1.28	.272	4.40	94	4.55	104	9.04	-26.3
3	Joel Pineiro J. Pineiro	658	185	58	55	.513	148	4.48	9	3	1	996.0	1,033	496	524	115	327	36	16	22	4,256	30	5.95	2.95	2.01	1.04	15.5	7.7	1.37	.294	4.73	104	4.31	99	9.33	4.8
4	Freddy Garcia F. Garcia	649	137	59	42	.584	136	3.85	7	3	0	895.0	830	383	408	101	299	26	0	16	3,772	30	6.53	3.01	2.17	1.02	17.2	7.9	1.26	.270	4.10	89	4.13	94	8.35	25.6
5	Gil Meche G. Meche	528	131	47	40	.540	128	4.64	4	2	0	729.2	737	376	405	100	306	19	2	5	3,162	21	6.51	3.77	1.73	1.23	16.7	9.7	1.43	.288	5.00	107	4.74	107	9.09	-26.8
6	Ryan Franklin R. Franklin	421	175	35	50	.412	106	4.33	6	3	0	800.0	828	385	413	122	230	35	24	13	3,409	6	4.74	2.59	1.83	1.37	12.3	6.7	1.32	.271	4.65	101	4.94	114	9.32	-54.4
7	Jarrod Washburn J. Washburn	383	111	31	49	.388	109	4.17	3	2	1	667.1	682	309	334	78	205	25	1	10	2,854	8	5.17	2.76	1.87	1.05	13.4	7.2	1.33	.279	4.50	97	4.56	105	9.20	-17.3
8	J.J. Putz	337	308	22	15	.595	0	3.07	0	0	101	323.0	270	110	115	32	104	13	207	9	1,326	9	9.39	2.90	3.24	0.89	25.4	7.8	1.16	.283	3.20	71	3.40	78	7.52	34.6
9	Arthur Rhodes A. Rhodes	315	312	28	16	.636	0	3.05	0	0	9	283.0	212	96	99	19	85	2	52	8	1,116	12	10.02	2.70	3.71	0.60	28.2	7.6	1.05	.278	3.15	69	2.61	59	6.74	57.6
10	Aaron Sele A. Sele	304	89	38	27	.585	88	4.39	5	4	0	542.2	584	265	279	60	166	17	0	11	2,330	8	5.04	2.75	1.83	1.00	13.0	7.1	1.38	.294	4.63	99	4.40	99	9.69	4.6
11	Miguel Batista M. Batista	258	133	27	29	.482	52	4.84	0	0	2	379.1	423	204	227	44	203	16	27	10	1,742	24	6.12	4.82	1.27	1.04	14.8	11.7	1.65	.310	5.39	113	5.05	118	10.04	-32.3
12	Kazuhiro Sasaki K. Sasaki	242	228	7	16	.304	0	3.14	0	0	129	223.1	165	78	90	24	77	9	201	13	925	15	9.75	3.10	3.14	0.97	26.2	8.3	1.08	.246	3.63	72	3.42	77	6.65	25.4
13	Paul Abbott P. Abbott	240	70	27	14	.659	59	4.79	1	0	0	368.1	349	196	204	49	187	13	3	9	1,613	16	5.86	4.57	1.28	1.20	14.9	11.6	1.46	.267	4.98	108	5.13	114	8.53	-25.8
14	Jeff Nelson J. Nelson	224	205	11	10	.524	0	3.40	0	0	14	185.1	132	70	74	13	107	15	68	5	797	10	10.88	5.20	2.09	0.63	28.1	13.4	1.29	.272	3.59	80	3.48	81	6.41	17.4
15	Julio Mateo J. Mateo	216	219	18	12	.600	1	3.68	0	0	2	318.1	298	130	136	45	85	21	54	19	1,337	6	6.11	2.40	2.54	1.27	16.2	6.4	1.20	.261	3.85	85	4.53	104	8.43	-6.3
16	John Halama J. Halama	207	92	30	21	.588	57	4.57	1	1	0	378.0	450	192	222	46	115	9	18	5	1,659	8	4.93	2.74	1.80	1.10	12.5	6.9	1.49	.315	5.29	102	4.53	101	10.71	-1.8
17	Brandon Morrow B. Morrow	204	131	8	12	.400	15	3.96	0	0	16	197.2	162	87	93	23	128	1	51	7	867	12	9.29	5.83	1.59	1.05	23.5	14.8	1.47	.272	4.23	93	4.55	106	7.38	-5.8
18	Rafael Soriano R. Soriano	177	116	4	8	.333	8	2.89	0	0	4	171.0	134	55	57	16	53	6	31	2	697	4	9.32	2.79	3.34	0.84	25.4	7.6	1.09	.265	3.00	68	3.23	74	7.05	21.8
19	Ryan Rowland-Smith R. Rowland-Smith	171	88	11	7	.611	27	3.62	0	0	2	253.1	240	102	111	26	90	8	15	1	1,075	4	6.08	3.20	1.90	0.92	15.9	8.4	1.30	.274	3.94	85	4.27	100	8.53	0.1
20	Erik Bedard E. Bedard	162	30	11	7	.611	30	3.24	0	0	0	164.0	135	59	67	17	71	8	0	0	695	5	8.89	3.90	2.28	0.93	23.3	10.2	1.26	.270	3.68	77	3.92	92	7.41	6.4
21	Mark Lowe M. Lowe	147	151	4	12	.250	0	3.98	0	0	4	165.0	163	73	89	15	75	6	41	2	730	7	8.02	4.09	1.96	0.82	20.1	10.3	1.44	.304	4.85	94	3.98	93	8.89	5.8
22	Shigetoshi Hasegawa S. Hasegawa	147	230	15	16	.484	0	3.46	0	0	17	278.0	255	107	111	18	95	7	92	16	1,150	1	4.76	3.08	1.55	0.58	12.8	8.3	1.26	.268	3.59	81	3.89	90	8.26	13.8
23	George Sherrill G. Sherrill	138	195	10	8	.556	0	3.65	0	0	4	128.1	95	52	55	10	60	3	28	8	537	5	9.68	4.21	2.30	0.70	25.7	11.2	1.21	.261	3.86	84	3.47	79	6.66	13.1
24	Sean Green S. Green	130	160	9	7	.563	0	4.32	0	0	1	179.0	191	86	94	7	83	11	34	8	801	9	6.54	4.17	1.57	0.35	16.2	10.4	1.53	.323	4.73	101	3.80	88	9.60	10.2
25	Ron Villone R. Villone	127	108	10	9	.526	10	3.66	0	0	1	157.1	135	64	78	14	87	17	28	4	701	8	7.26	4.98	1.46	0.80	18.1	12.4	1.41	.265	4.46	83	4.56	104	7.72	-3.1