The 2021 roster for the Twins included José Berríos at pitcher, Ryan Jeffers at catcher, Miguel Sanó at first baseman, Jorge Polanco at second baseman and Josh Donaldson at third baseman.

	NO.	NAME	POS	HEIGHT	WEIGHT	DOB	AGE	BIRTHPLACE
1		Andrew Albers A. Albers	P	6'1"	200	10/6/1985	35	North Battleford, Canada
2	66	Jorge Alcala J. Alcala	P	6'3"	205	7/28/1995	25	Bajos de Haina, Dominican Republic
3	41	Shaun Anderson S. Anderson	P	6'4"	225	10/29/1994	26	Coral Springs, FL
4	2	Luis Arraez L. Arraez	3B	5'10"	177	4/9/1997	24	San Felipe, Venezuela
5	64	Willians Astudillo W. Astudillo	1B	5'9"	225	10/14/1991	29	Barcelona, Venezuela
6	81	Jordan Balazovic J. Balazovic	P	6'5"	215	9/17/1998	22	Mississauga, Canada
7	85	Charlie Barnes C. Barnes	P	6'2"	190	10/1/1995	25	Sumter, SC
8	45	Kyle Barraclough K. Barraclough	P	6'3"	225	5/23/1990	31	Santa Clara, CA
9	17	José Berríos J. Berríos	P	6'0"	205	5/27/1994	27	Bayamon, Puerto Rico
10	13	Travis Blankenhorn T. Blankenhorn	3B	6'2"	228	8/3/1996	24	Pottsville, PA
11	41	Beau Burrows B. Burrows	P	6'2"	215	9/18/1996	24	Fort Worth, TX
12	25	Byron Buxton B. Buxton	CF	6'2"	190	12/18/1993	27	Baxley, GA
13	60	Jake Cave J. Cave	CF	6'0"	200	12/4/1992	28	Hampton, VA
14	79	Gilberto Celestino G. Celestino	CF	6'0"	170	2/13/1999	22	Santo Domingo, Dominican Republic
15	48	Alex Colome A. Colome	P	6'1"	220	12/31/1988	32	Santo Domingo, Dominican Republic
16	53	Danny Coulombe D. Coulombe	P	5'10"	190	10/26/1989	31	St. Louis, MO
17	23	Nelson Cruz N. Cruz	DH	6'2"	230	7/1/1980	41	Las Matas de Santa Cruz, Dominican Republic
18	68	Randy Dobnak R. Dobnak	P	6'1"	230	1/17/1995	26	South Park, PA
19	20	Josh Donaldson J. Donaldson	3B	6'1"	210	12/8/1985	35	Pensacola, FL
20	21	Tyler Duffey T. Duffey	P	6'3"	220	12/27/1990	30	Houston, TX
21	59	Jhoan Duran J. Duran	P	6'5"	230	1/8/1998	23	Esperanza, Dominican Republic
22	51	Luke Farrell L. Farrell	P	6'6"	210	6/7/1991	30	Westlake, OH
23	33	John Gant J. Gant	P	6'3"	200	8/6/1992	28	Savannah, GA
24	57	Edgar Garcia E. Garcia	P	6'1"	180	10/4/1996	24	Palenque, Dominican Republic
25	30	Kyle Garlick K. Garlick	LF	6'1"	210	1/26/1992	29	La Habra, CA