The Washington Senators had the most runs by an AL team in a game in 1915, with 20 runs against the Philadelphia Athletics on September 29, 1915.

Interpreted as:

MLB al team most runs in a regular-season game 1915

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Senators	20	9/29/1915	WSH	vs	PHA	W 20-5	43	23	4	2	0		4	1	3	7	52	31	6	4	.535	.583	.721	1.304
2	White Sox	16	4/15/1915	CWS	@	SLA	W 16-0	37	15	4	0	0		8	0	4	6	48	19	4	3	.405	.511	.514	1.025
3	Red Sox	15	7/12/1915	BSA	@	DET	W 15-12	46	15	4	0	0		5	0	4	5	52	19	4	1	.326	.392	.413	.805
4	Tigers	15	7/9/1915	DET	vs	BSA	W 15-4	34	14	2	1	0	13	8	0	3	8	44	18	3	2	.412	.524	.529	1.053
5	Yankees	15	6/23/1915	NYY	@	PHA	W 15-7	36	13	0	0	0		16	0	4	2	53	13	0	1	.361	.558	.361	.919
6	Tigers	15	6/9/1915	DET	@	BSA	W 15-0	40	17	4	4	0	14	9	0	5	5	51	29	8	2	.425	.531	.725	1.256
7	White Sox	13	9/29/1915	CWS	@	CLE	W 13-6	37	17	4	2	0	11	6	0	1	2	48	25	6	5	.459	.535	.676	1.211
8	Tigers	13	9/22/1915	DET	@	PHA	W 13-9	38	10	0	1	0	10	11	0	4	4	50	12	1	1	.263	.429	.316	.744
9	Red Sox	13	9/8/1915	BSA	vs	PHA	W 13-2	31	11	1	0	0		12	1	1	0	47	12	1	3	.355	.545	.387	.933
10	Yankees	13	7/7/1915	NYY	vs	PHA	W 13-5	28	12	3	1	0		14	0	2	3	46	17	4	4	.429	.619	.607	1.226
11	Browns	13	6/22/1915	SLA	@	DET	W 13-9	62	21	2	2	0	12	5	1	11	2	70	27	4	2	.339	.397	.435	.833
12	White Sox	13	6/9/1915	CWS	@	NYY	W 13-0	44	18	2	2	1	12	4	1	2	2	50	27	5	1	.409	.469	.614	1.083
13	White Sox	12	9/24/1915	CWS	@	PHA	W 12-5	36	13	3	0	1	8	6	0	1	3	45	19	4	3	.361	.452	.528	.980
14	Browns	12	9/14/1915	SLA	@	PHA	W 12-4	36	12	1	1	1		9	0	3	4	45	18	3	0	.333	.467	.500	.967
15	Indians	12	7/24/1915	CLE	vs	PHA	W 12-4	30	10	1	1	0		9	1	2	4	43	13	2	3	.333	.500	.433	.933
16	Tigers	12	7/19/1915	DET	vs	PHA	W 12-6	28	13	4	0	0	11	10	0	2	3	42	17	4	4	.464	.605	.607	1.212
17	Tigers	12	7/14/1915	DET	vs	NYY	W 12-3	34	15	1	1	0	10	5	1	1	1	41	18	2	1	.441	.525	.529	1.054
18	Tigers	12	7/12/1915	DET	vs	BSA	L 12-15	40	12	1	1	1	11	10	0	3	0	51	18	3	1	.300	.440	.450	.890
19	White Sox	12	7/11/1915	CWS	vs	WSH	W 12-5	33	16	1	1	0		5	1	0	2	41	19	2	2	.485	.564	.576	1.140
20	White Sox	12	7/6/1915	CWS	@	SLA	W 12-2	41	15	4	1	1	11	4	1	4	2	49	24	6	3	.366	.435	.585	1.020
21	Tigers	12	6/27/1915	DET	vs	CLE	W 12-2	33	14	2	1	1	12	7	0	2	3	43	21	4	3	.424	.525	.636	1.161
22	Red Sox	12	6/24/1915	BSA	@	WSH	W 12-4	34	14	2	1	0	10	7	0	2	3	47	18	3	6	.412	.512	.529	1.042
23	Athletics	12	6/21/1915	PHA	vs	NYY	W 12-7	28	7	0	2	0	9	7	1	6	0	38	11	2	2	.250	.417	.393	.810
24	Yankees	12	6/14/1915	NYY	vs	SLA	W 12-7	34	13	0	0	2	10	6	0	6	5	41	19	2	1	.382	.475	.559	1.034
25	Indians	12	5/31/1915	CLE	vs	SLA	W 12-1	40	18	3	3	0	11	4	1	1	1	45	27	6	0	.450	.511	.675	1.186