The Atlanta Braves had the highest run differential by a team in 2003, with a differential of 167 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Braves	167	2003	162	.623	101	61	5,670	907	1,608	321	31	235	872	545	49	933	68	22	6,378	2,696	587	65	49	46	124	.284	.349	.475	.824
2	Yankees	161	2003	163	.623	101	61	5,605	877	1,518	304	14	230	845	684	81	1,042	98	33	6,430	2,540	548	25	35	54	154	.271	.356	.453	.810
3	Mariners	158	2003	162	.574	93	69	5,561	795	1,509	290	33	139	759	586	53	989	108	37	6,281	2,282	462	35	46	34	130	.271	.344	.410	.754
4	Red Sox	152	2003	162	.586	95	67	5,769	961	1,667	371	40	238	932	620	53	943	88	35	6,530	2,832	649	24	64	61	126	.289	.360	.491	.851
5	Astros	128	2003	162	.537	87	75	5,583	805	1,466	308	30	191	763	557	81	1,021	66	30	6,320	2,407	529	61	38	44	125	.263	.336	.431	.767
6	Athletics	125	2003	162	.593	96	66	5,497	768	1,398	317	24	176	742	556	59	898	48	14	6,187	2,291	517	22	53	52	118	.254	.327	.417	.743
7	Giants	117	2003	161	.621	100	61	5,456	755	1,440	281	29	180	713	593	40	980	53	37	6,204	2,319	490	76	39	79	130	.264	.338	.425	.763
8	Phillies	94	2003	162	.531	86	76	5,543	791	1,448	325	27	166	757	651	55	1,155	72	29	6,333	2,325	518	46	38	56	120	.261	.343	.419	.762
9	Cardinals	80	2003	162	.525	85	77	5,672	876	1,580	342	32	196	827	580	73	952	82	32	6,466	2,574	570	87	54	68	136	.279	.350	.454	.804
10	White Sox	76	2003	162	.531	86	76	5,487	791	1,445	303	19	220	766	519	58	916	77	29	6,148	2,446	542	43	41	27	132	.263	.331	.446	.777
11	Blue Jays	68	2003	162	.531	86	76	5,661	894	1,580	357	33	190	853	546	90	1,081	37	25	6,364	2,573	580	11	56	40	146	.279	.349	.455	.803
12	Marlins	59	2003	162	.562	91	71	5,490	751	1,459	292	44	157	709	515	57	978	150	74	6,185	2,310	493	82	41	44	114	.266	.333	.421	.754
13	Twins	43	2003	162	.556	90	72	5,655	801	1,567	318	45	155	755	512	63	1,027	94	44	6,324	2,440	518	42	52	36	139	.277	.341	.431	.772
14	Cubs	41	2003	162	.543	88	74	5,519	724	1,431	302	24	172	691	492	50	1,158	73	31	6,187	2,297	498	80	46	40	135	.259	.323	.416	.739
15	Diamondbacks	32	2003	162	.519	84	78	5,570	717	1,467	303	47	152	696	531	45	1,006	76	38	6,261	2,320	502	63	52	63	126	.263	.330	.417	.746
16	Dodgers	18	2003	162	.525	85	77	5,458	574	1,328	260	25	124	544	407	72	985	80	36	6,036	2,010	409	71	28	43	121	.243	.303	.368	.671
17	Expos	-5	2003	162	.512	83	79	5,437	711	1,404	294	25	144	682	522	45	990	100	39	6,116	2,180	463	72	40	58	143	.258	.326	.401	.727
18	Angels	-7	2003	162	.475	77	85	5,487	736	1,473	276	33	150	687	476	56	838	129	61	6,119	2,265	459	50	50	42	125	.268	.330	.413	.743
19	Royals	-31	2003	162	.512	83	79	5,568	836	1,526	288	39	162	781	476	75	926	120	42	6,239	2,378	489	63	57	32	128	.274	.336	.427	.763
20	Rockies	-39	2003	162	.457	74	88	5,518	853	1,472	330	31	198	814	619	52	1,134	63	37	6,282	2,458	559	55	38	46	140	.267	.344	.445	.790
21	Pirates	-48	2003	162	.463	75	87	5,581	753	1,492	275	45	163	711	529	87	1,049	86	37	6,314	2,346	483	79	38	42	112	.267	.338	.420	.758
22	Orioles	-77	2003	163	.438	71	91	5,665	743	1,516	277	24	152	695	431	54	902	89	36	6,241	2,297	453	51	40	32	123	.268	.323	.405	.729
23	Indians	-79	2003	162	.420	68	94	5,572	699	1,413	296	26	158	660	466	62	1,062	86	61	6,187	2,235	480	46	41	25	128	.254	.316	.401	.717
24	Mets	-112	2003	161	.410	66	95	5,341	642	1,317	262	24	124	607	489	54	1,035	70	31	6,007	1,999	410	78	45	42	136	.247	.314	.374	.688
25	Devil Rays	-137	2003	162	.389	63	99	5,654	715	1,501	298	38	137	678	420	56	1,030	142	42	6,212	2,286	473	32	50	46	108	.265	.320	.404	.724