The Chicago Cubs had the highest run differential by a team in 2008, with a differential of 184 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	184	2008	161	.602	97	64	5,588	855	1,552	329	21	184	811	636	50	1,186	87	34	6,384	2,475	534	65	45	48	134	.278	.354	.443	.797
2	Red Sox	151	2008	162	.586	95	67	5,596	845	1,565	353	33	173	807	646	70	1,068	120	35	6,402	2,503	559	28	62	49	147	.280	.358	.447	.805
3	Phillies	119	2008	162	.568	92	70	5,509	799	1,407	291	36	214	762	586	67	1,117	136	25	6,273	2,412	541	71	40	68	108	.255	.332	.438	.770
4	Blue Jays	104	2008	162	.531	86	76	5,503	714	1,453	303	32	126	681	521	59	938	80	27	6,187	2,198	461	48	56	34	150	.264	.331	.399	.731
5	Rays	103	2008	162	.599	97	65	5,541	774	1,443	284	37	180	735	626	68	1,224	142	50	6,310	2,341	501	23	52	33	111	.260	.340	.422	.762
6	Twins	84	2008	163	.540	88	75	5,641	829	1,572	298	49	111	791	529	36	979	102	42	6,330	2,301	458	52	72	48	142	.279	.340	.408	.748
7	Mets	84	2008	162	.549	89	73	5,606	799	1,491	274	38	172	751	619	39	1,024	138	36	6,386	2,357	484	73	49	71	129	.266	.340	.420	.761
8	White Sox	82	2008	163	.546	89	74	5,553	811	1,458	296	13	235	785	540	63	1,016	67	34	6,231	2,485	544	28	47	33	157	.263	.332	.448	.780
9	Angels	68	2008	162	.617	100	62	5,540	765	1,486	274	25	159	721	481	52	987	129	48	6,155	2,287	458	32	50	52	140	.268	.330	.413	.743
10	Yankees	62	2008	162	.549	89	73	5,572	789	1,512	289	20	180	758	535	80	1,015	118	39	6,257	2,381	489	31	39	36	149	.271	.342	.427	.769
11	Brewers	61	2008	162	.556	90	72	5,535	750	1,398	324	35	198	722	550	69	1,203	108	38	6,251	2,386	557	54	43	44	97	.253	.325	.431	.757
12	Cardinals	54	2008	162	.531	86	76	5,636	779	1,585	283	26	174	744	577	42	985	73	32	6,370	2,442	483	71	44	63	150	.281	.350	.433	.783
13	Dodgers	52	2008	162	.519	84	78	5,506	700	1,455	271	29	137	659	543	43	1,032	126	43	6,194	2,195	437	64	38	62	153	.264	.333	.399	.732
14	Indians	44	2008	162	.500	81	81	5,543	805	1,455	339	22	171	772	560	103	1,213	77	29	6,298	2,351	532	43	49	44	123	.262	.339	.424	.763
15	Diamondbacks	14	2008	162	.506	82	80	5,409	720	1,355	318	47	159	683	587	49	1,287	58	23	6,156	2,244	524	68	43	49	105	.251	.327	.415	.742
16	Marlins	3	2008	161	.522	84	77	5,499	770	1,397	302	28	208	741	543	69	1,371	76	28	6,206	2,379	538	49	46	50	98	.254	.326	.433	.759
17	Braves	-25	2008	162	.444	72	90	5,604	753	1,514	316	33	130	721	618	42	1,023	58	27	6,367	2,286	479	69	34	56	143	.270	.345	.408	.753
18	Astros	-31	2008	161	.534	86	75	5,451	712	1,432	284	22	167	684	449	52	1,051	114	52	6,050	2,261	473	57	41	42	116	.263	.323	.415	.737
19	Tigers	-36	2008	162	.457	74	88	5,641	821	1,529	293	41	200	780	572	44	1,076	63	31	6,331	2,504	534	30	44	23	144	.271	.340	.444	.784
20	Athletics	-44	2008	161	.466	75	86	5,451	646	1,318	270	23	125	610	574	48	1,226	88	21	6,138	2,009	418	30	35	23	126	.242	.318	.369	.686
21	Rangers	-66	2008	162	.488	79	83	5,728	901	1,619	376	35	194	867	595	63	1,207	81	25	6,477	2,647	605	37	54	43	117	.283	.354	.462	.816
22	Rockies	-75	2008	162	.457	74	88	5,557	747	1,462	310	28	160	714	570	57	1,209	141	37	6,312	2,308	498	90	38	36	119	.263	.336	.415	.751
23	Orioles	-87	2008	161	.422	68	93	5,559	782	1,486	322	30	172	750	533	42	990	81	37	6,209	2,384	524	27	48	37	111	.267	.333	.429	.762
24	Royals	-90	2008	162	.463	75	87	5,608	691	1,507	303	28	120	650	392	50	1,005	79	38	6,118	2,226	451	32	36	31	144	.269	.320	.397	.717
25	Reds	-96	2008	162	.457	74	88	5,465	704	1,351	269	24	187	677	560	50	1,125	85	47	6,188	2,229	480	72	41	50	101	.247	.321	.408	.729