The Detroit Tigers have the highest run differential by a team this season, with a differential of 86 runs.

Interpreted as:

MLB best run differential losing record this regular season

	TEAM	DIFF	L	REC	SEASON	W	L%	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Tigers	86	16	30-16	2025	30	.348	.652	46	1,569	250	407	66	7	60	238	158	19	405	19	3	1,763	667	133	4	13	4	29	.259	.332	.425	.757
2	Yankees	84	19	26-19	2025	26	.422	.578	45	1,541	258	404	84	6	78	248	184	25	405	33	10	1,769	734	168	1	18	9	26	.262	.347	.476	.823
3	Cubs	66	19	27-19	2025	27	.413	.587	46	1,596	264	404	81	12	65	259	181	14	368	57	10	1,810	704	158	5	14	5	20	.253	.332	.441	.773
4	Dodgers	65	17	29-17	2025	29	.370	.630	46	1,574	268	431	80	9	76	257	176	14	380	33	9	1,783	757	165	3	16	7	36	.274	.349	.481	.830
5	Mets	62	17	29-17	2025	29	.370	.630	46	1,528	210	382	82	11	52	202	169	26	348	34	5	1,741	642	145	1	17	6	40	.250	.332	.420	.752
6	Giants	46	19	27-19	2025	27	.413	.587	46	1,532	219	364	75	5	49	209	163	12	399	25	11	1,726	596	129	7	12	4	24	.238	.314	.389	.703
7	Padres	43	17	27-17	2025	27	.386	.614	44	1,464	198	384	66	6	40	180	142	12	303	36	9	1,642	582	112	10	14	5	29	.262	.330	.398	.727
8	Cardinals	39	20	26-20	2025	26	.435	.565	46	1,570	223	409	90	1	44	210	160	19	352	31	10	1,767	633	135	4	14	8	37	.261	.334	.403	.737
9	Twins	38	20	26-20	2025	26	.435	.565	46	1,535	192	374	76	6	44	183	130	25	376	25	9	1,700	594	126	0	10	3	28	.244	.311	.387	.698
10	Reds	28	24	23-24	2025	23	.511	.489	47	1,579	217	382	79	3	51	209	167	18	425	51	14	1,775	620	133	3	8	4	26	.242	.320	.393	.713
11	Phillies	23	18	27-18	2025	27	.400	.600	45	1,534	215	397	70	7	46	205	174	14	356	41	8	1,736	619	123	4	10	6	31	.259	.338	.404	.741
12	Astros	19	22	23-22	2025	23	.489	.511	45	1,490	181	368	66	5	37	172	146	17	350	22	9	1,672	555	108	8	11	5	33	.247	.319	.372	.692
13	Mariners	18	19	25-19	2025	25	.432	.568	44	1,488	210	355	56	2	61	202	174	24	392	45	13	1,704	598	119	8	10	3	26	.239	.326	.402	.728
14	Red Sox	14	24	23-24	2025	23	.511	.489	47	1,638	230	417	86	7	59	220	160	20	432	48	12	1,831	694	152	3	10	10	21	.255	.327	.424	.750
15	Braves	5	23	23-23	2025	23	.500	.500	46	1,558	185	378	63	6	49	177	154	14	390	30	9	1,739	600	118	5	8	4	25	.243	.315	.385	.700
16	Rangers	2	22	25-22	2025	25	.468	.532	47	1,515	163	345	59	4	50	160	121	16	363	38	10	1,666	562	113	2	12	2	26	.228	.290	.371	.661
17	Diamondbacks	2	22	24-22	2025	24	.478	.522	46	1,559	242	401	98	8	63	235	180	21	344	42	11	1,788	704	169	8	20	6	33	.257	.338	.452	.790
18	Royals	-2	22	25-22	2025	25	.468	.532	47	1,568	157	376	78	10	30	155	119	14	326	39	14	1,725	564	118	9	15	7	22	.240	.297	.360	.656
19	Rays	-5	24	21-24	2025	21	.533	.467	45	1,511	178	370	63	3	39	170	137	10	383	55	12	1,673	556	105	0	15	0	32	.245	.309	.368	.677
20	Brewers	-10	25	21-25	2025	21	.543	.457	46	1,517	193	347	59	4	37	174	153	20	379	59	14	1,710	525	100	10	10	6	24	.229	.306	.346	.652
21	Guardians	-18	20	25-20	2025	25	.444	.556	45	1,453	181	337	57	3	51	170	145	17	352	35	12	1,640	553	111	7	18	6	26	.232	.306	.381	.686
22	Blue Jays	-27	23	22-23	2025	22	.511	.489	45	1,512	177	378	79	1	40	171	143	16	333	28	9	1,695	579	120	9	15	8	34	.250	.319	.383	.701
23	White Sox	-49	32	14-32	2025	14	.696	.304	46	1,490	155	322	59	1	36	150	144	10	391	37	7	1,659	491	96	5	10	1	25	.216	.288	.330	.617
24	Nationals	-55	27	20-27	2025	20	.574	.426	47	1,556	197	371	70	7	45	186	142	21	377	48	14	1,738	590	122	9	10	1	27	.238	.309	.379	.688
25	Athletics	-60	24	22-24	2025	22	.522	.478	46	1,577	197	400	73	6	58	190	133	7	348	20	6	1,730	659	137	3	10	2	42	.254	.313	.418	.731