The Chicago Cubs have the highest run differential by a team this season, with a differential of 126 runs.

Interpreted as:

MLB best run differential losing record this regular season

	TEAM	DIFF	L	REC	SEASON	W	L%	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	126	36	54-36	2025	54	.400	.600	90	3,116	492	802	158	19	136	481	315	24	700	106	18	3,490	1,406	313	7	28	10	36	.257	.328	.451	.779
2	Tigers	110	34	58-34	2025	58	.370	.630	92	3,114	461	789	147	19	119	442	296	41	798	32	8	3,486	1,331	285	5	30	7	49	.253	.323	.427	.751
3	Yankees	95	41	49-41	2025	49	.456	.544	90	3,067	462	782	158	14	140	442	358	36	801	63	20	3,495	1,388	312	4	30	28	60	.255	.337	.453	.789
4	Dodgers	69	36	56-36	2025	56	.391	.609	92	3,142	501	816	153	15	141	483	338	33	752	49	14	3,546	1,422	309	3	30	18	64	.260	.335	.453	.788
5	Astros	69	36	55-36	2025	55	.396	.604	91	3,065	401	798	133	10	105	382	263	42	696	47	20	3,404	1,266	248	9	25	8	73	.260	.325	.413	.738
6	Brewers	65	40	51-40	2025	51	.440	.560	91	3,048	429	752	131	9	88	399	314	37	729	104	30	3,445	1,165	228	18	28	10	47	.247	.322	.382	.704
7	Rays	65	42	49-42	2025	49	.462	.538	91	3,072	432	795	141	9	101	410	272	28	752	117	30	3,409	1,257	251	10	27	8	63	.259	.322	.409	.731
8	Phillies	53	38	53-38	2025	53	.418	.582	91	3,085	414	787	141	13	97	394	314	33	722	77	17	3,462	1,245	251	10	20	10	55	.255	.329	.404	.732
9	Mets	44	39	52-39	2025	52	.429	.571	91	3,031	402	744	142	13	118	392	311	57	710	69	10	3,433	1,266	273	5	29	15	75	.245	.324	.418	.742
10	Red Sox	39	45	47-45	2025	47	.489	.511	92	3,188	457	813	186	15	114	437	300	42	843	78	21	3,559	1,371	315	7	22	17	49	.255	.325	.430	.755
11	Giants	32	42	50-42	2025	50	.457	.543	92	3,023	384	700	142	15	85	364	323	40	780	45	17	3,431	1,127	242	18	27	8	61	.232	.311	.373	.684
12	Reds	28	45	46-45	2025	46	.495	.505	91	3,046	416	745	147	11	96	395	299	29	793	66	23	3,405	1,202	254	7	24	7	60	.245	.316	.395	.710
13	Rangers	24	47	44-47	2025	44	.516	.484	91	3,025	345	691	126	8	91	331	265	37	739	83	20	3,358	1,106	225	5	26	11	49	.228	.296	.366	.662
14	Mariners	22	42	48-42	2025	48	.467	.533	90	3,089	402	764	126	4	119	389	304	49	792	81	23	3,479	1,255	249	15	22	15	57	.247	.322	.406	.729
15	Blue Jays	16	38	53-38	2025	53	.418	.582	91	3,082	420	795	150	4	97	402	307	34	609	47	15	3,470	1,244	251	21	26	19	67	.258	.329	.404	.733
16	Cardinals	15	43	48-43	2025	48	.473	.527	91	3,086	414	777	154	4	91	394	284	46	708	47	15	3,450	1,212	249	9	25	12	64	.252	.322	.393	.714
17	Padres	9	42	48-42	2025	48	.467	.533	90	2,997	366	737	129	12	76	341	295	24	639	61	16	3,363	1,118	217	20	27	12	58	.246	.316	.373	.689
18	Braves	4	50	39-50	2025	39	.562	.438	89	3,011	357	731	123	9	92	344	308	27	771	43	13	3,373	1,148	224	7	20	10	56	.243	.317	.381	.698
19	Diamondbacks	3	46	45-46	2025	45	.505	.495	91	3,085	467	778	158	20	133	457	323	44	716	64	20	3,506	1,375	311	17	37	9	60	.252	.328	.446	.774
20	Twins	-18	47	43-47	2025	43	.522	.478	90	3,013	374	719	138	8	102	360	262	53	750	46	17	3,348	1,179	248	2	18	5	58	.239	.309	.391	.700
21	Royals	-24	48	44-48	2025	44	.522	.478	92	3,082	313	752	157	16	67	309	218	36	636	69	29	3,380	1,142	240	20	24	13	48	.244	.299	.371	.670
22	Pirates	-43	54	38-54	2025	38	.587	.413	92	3,035	313	698	118	14	62	303	291	30	805	77	22	3,385	1,030	194	8	21	12	77	.230	.302	.339	.641
23	Angels	-48	46	44-46	2025	44	.511	.489	90	3,015	385	690	121	10	130	371	259	49	884	40	19	3,351	1,221	261	8	20	14	53	.229	.299	.405	.704
24	Guardians	-57	48	41-48	2025	41	.539	.461	89	2,900	319	651	126	8	87	304	274	29	731	67	22	3,245	1,054	221	13	29	14	51	.224	.295	.363	.659
25	Marlins	-67	48	41-48	2025	41	.539	.461	89	3,047	375	770	148	15	80	361	263	21	721	70	27	3,370	1,188	243	16	23	7	51	.253	.314	.390	.704