The Chicago White Sox had the highest run differential by a team in 1983, with a differential of 150 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	White Sox	150	1983	162	.611	99	63	5,484	800	1,439	270	42	157	762	527	43	888	165	50	6,163	2,264	469	53	56	50	111	.262	.329	.413	.742
2	Orioles	147	1983	162	.605	98	64	5,546	799	1,492	283	27	168	761	601	23	800	61	33	6,272	2,333	478	46	56	48	144	.269	.340	.421	.761
3	Tigers	110	1983	162	.568	92	70	5,592	789	1,530	283	53	156	749	508	39	831	93	53	6,246	2,387	492	48	59	37	123	.274	.335	.427	.762
4	Braves	106	1983	162	.543	88	74	5,472	746	1,489	218	45	130	691	582	17	847	146	88	6,195	2,187	393	78	46	72	129	.272	.341	.400	.741
5	Blue Jays	69	1983	162	.549	89	73	5,581	795	1,546	268	58	167	748	510	32	810	131	72	6,213	2,431	493	36	54	44	117	.277	.338	.436	.774
6	Yankees	67	1983	162	.562	91	71	5,631	770	1,535	269	40	153	728	533	37	686	84	42	6,279	2,343	462	37	41	36	148	.273	.337	.416	.753
7	Phillies	61	1983	163	.556	90	72	5,426	696	1,352	209	45	125	649	640	26	906	143	75	6,218	2,026	379	80	46	75	132	.249	.329	.373	.702
8	Brewers	56	1983	162	.537	87	75	5,620	764	1,556	281	57	132	732	475	27	665	101	49	6,240	2,347	470	61	57	51	135	.277	.333	.418	.751
9	Dodgers	45	1983	163	.562	91	71	5,440	654	1,358	197	34	146	613	541	22	925	166	76	6,129	2,061	377	86	40	61	112	.250	.318	.379	.697
10	Expos	31	1983	163	.506	82	80	5,611	677	1,482	297	41	102	632	509	38	733	138	44	6,293	2,167	440	78	57	76	133	.264	.326	.386	.713
11	Rangers	30	1983	163	.475	77	85	5,610	639	1,429	242	33	106	587	442	29	767	119	60	6,161	2,055	381	38	42	33	123	.255	.310	.366	.677
12	Pirates	11	1983	162	.519	84	78	5,531	659	1,460	238	29	121	612	497	19	873	124	77	6,169	2,119	388	84	38	63	121	.264	.325	.383	.708
13	Padres	0	1983	163	.500	81	81	5,527	653	1,384	207	34	93	592	482	20	822	179	67	6,163	1,938	334	89	45	80	121	.250	.311	.351	.661
14	Astros	-3	1983	162	.525	85	77	5,502	643	1,412	239	60	97	615	517	19	869	164	95	6,173	2,062	396	81	54	71	76	.257	.320	.375	.695
15	Giants	-10	1983	162	.488	79	83	5,369	687	1,324	206	30	142	638	619	28	990	140	78	6,126	2,016	378	64	46	63	129	.247	.325	.375	.701
16	Cubs	-18	1983	162	.438	71	91	5,512	701	1,436	272	42	140	649	470	29	868	84	40	6,132	2,212	454	71	50	63	113	.261	.319	.401	.721
17	Cardinals	-31	1983	162	.488	79	83	5,550	679	1,496	262	63	83	636	543	24	879	207	89	6,238	2,133	408	72	49	66	117	.270	.335	.384	.719
18	Red Sox	-51	1983	162	.481	78	84	5,590	724	1,512	287	32	142	691	536	28	758	30	26	6,251	2,289	461	49	48	44	171	.270	.335	.409	.744
19	Angels	-57	1983	162	.432	70	92	5,640	722	1,467	241	22	154	682	509	31	835	41	39	6,294	2,214	417	68	46	39	147	.260	.322	.393	.715
20	Royals	-71	1983	163	.488	79	83	5,598	696	1,515	273	54	109	653	397	23	722	182	47	6,083	2,223	436	32	33	41	123	.271	.320	.397	.717
21	Athletics	-74	1983	162	.457	74	88	5,516	708	1,447	237	28	121	662	524	31	872	235	98	6,188	2,103	386	55	62	47	128	.262	.326	.381	.708
22	Indians	-81	1983	162	.432	70	92	5,476	704	1,451	249	31	86	659	605	29	691	109	71	6,222	2,020	366	48	64	38	146	.265	.338	.369	.707
23	Reds	-87	1983	162	.457	74	88	5,333	623	1,274	236	35	107	577	588	19	1,006	154	77	6,057	1,901	378	72	45	69	121	.239	.314	.356	.671
24	Mets	-105	1983	162	.420	68	94	5,444	575	1,314	172	26	112	542	436	31	1,031	141	64	6,009	1,874	310	66	32	54	113	.241	.300	.344	.644
25	Twins	-113	1983	162	.432	70	92	5,601	709	1,463	280	41	141	671	467	29	802	44	29	6,171	2,248	462	29	45	27	150	.261	.319	.401	.720