Between the 2000 and 2020 seasons, Mark Buehrle allowed the most hits, with 3,472 hits.

	NAME	H	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Mark Buehrle M. Buehrle	3,472	518	214	160	.572	493	3.81	1,870	33	10	0	3283.1	1,391	1,542	361	734	79	6	49	13,705	27	5.13	2.01	2.55	0.99	13.6	5.4	1.28	.292	4.23	87	4.11	93	9.52	111.9
2	CC Sabathia	3,404	561	251	161	.609	560	3.74	3,093	38	12	0	3577.1	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
3	Bartolo Colon B. Colon	3,096	483	211	167	.558	472	4.11	2,150	30	10	0	2958.2	1,351	1,465	388	748	51	2	36	12,487	32	6.54	2.28	2.87	1.18	17.2	6.0	1.30	.296	4.46	96	4.14	97	9.42	44.8
4	Livan Hernandez L. Hernandez	2,949	438	151	150	.502	394	4.45	1,596	39	9	1	2655.2	1,312	1,404	297	846	67	17	72	11,472	35	5.41	2.87	1.89	1.01	13.9	7.4	1.43	.306	4.76	105	4.35	102	9.99	-29.4
5	John Lackey J. Lackey	2,862	448	188	147	.561	446	3.92	2,294	18	8	0	2840.1	1,237	1,347	319	815	133	0	32	12,030	125	7.27	2.58	2.81	1.01	19.1	6.8	1.29	.300	4.27	92	3.94	94	9.07	79.6
6	Tim Hudson T. Hudson	2,836	461	211	131	.617	458	3.50	1,948	25	13	0	2990.1	1,164	1,263	240	855	120	0	82	12,425	78	5.86	2.57	2.28	0.72	15.7	6.9	1.23	.280	3.80	84	3.79	91	8.54	131.3
7	Zack Greinke Z. Greinke	2,728	500	208	126	.623	459	3.37	2,689	16	5	1	2939.0	1,100	1,181	298	676	70	8	25	12,002	89	8.23	2.07	3.98	0.91	22.4	5.6	1.16	.294	3.62	80	3.36	81	8.35	253.4
8	Kyle Lohse K. Lohse	2,711	457	147	143	.507	418	4.40	1,615	12	9	2	2531.2	1,239	1,327	316	694	87	15	34	10,839	57	5.74	2.47	2.33	1.12	14.9	6.4	1.34	.295	4.72	105	4.35	105	9.64	-58.3
9	James Shields J. Shields	2,581	407	145	139	.511	405	4.01	2,234	23	9	0	2616.0	1,167	1,267	361	746	97	1	22	10,993	107	7.69	2.57	2.99	1.24	20.3	6.8	1.27	.294	4.36	98	4.16	101	8.88	-13.5
10	Justin Verlander J. Verlander	2,538	454	226	129	.637	454	3.33	3,013	26	9	0	2988.0	1,105	1,192	310	851	98	0	27	12,214	87	9.08	2.56	3.54	0.93	24.7	7.0	1.13	.281	3.59	78	3.40	80	7.64	280.4
11	Bronson Arroyo B. Arroyo	2,507	419	148	137	.519	383	4.28	1,571	16	6	1	2435.2	1,158	1,260	347	661	105	6	60	10,338	42	5.80	2.44	2.38	1.28	15.2	6.4	1.30	.282	4.66	100	4.59	108	9.26	-82
12	Felix Hernandez F. Hernandez	2,487	419	169	136	.554	418	3.42	2,524	25	11	0	2729.2	1,037	1,157	264	805	105	0	16	11,284	156	8.32	2.65	3.14	0.87	22.4	7.1	1.21	.293	3.81	84	3.52	85	8.20	181.5
13	A.J. Burnett	2,482	428	160	155	.508	423	3.99	2,480	24	10	0	2690.0	1,194	1,305	260	1,075	143	1	33	11,483	161	8.30	3.60	2.31	0.87	21.6	9.4	1.32	.295	4.37	97	3.85	92	8.30	96.2
14	Roy Halladay R. Halladay	2,481	378	194	98	.664	370	3.36	2,022	65	19	0	2586.0	966	1,055	215	511	77	4	27	10,566	50	7.04	1.78	3.96	0.75	19.1	4.8	1.16	.293	3.67	77	3.27	75	8.63	304.7
15	Derek Lowe D. Lowe	2,475	524	165	139	.543	358	4.03	1,513	10	4	67	2370.0	1,061	1,184	194	704	66	127	58	10,097	44	5.75	2.67	2.15	0.74	15.0	7.0	1.34	.299	4.50	94	3.83	90	9.40	111.4
16	Jon Lester J. Lester	2,451	424	193	111	.635	423	3.60	2,397	15	4	0	2598.2	1,040	1,131	269	837	87	0	8	10,860	63	8.30	2.90	2.86	0.93	22.1	7.7	1.27	.300	3.92	84	3.68	90	8.49	120.4
17	Aaron Harang A. Harang	2,445	387	128	143	.472	381	4.26	1,842	15	8	0	2322.0	1,099	1,177	298	712	63	2	54	9,975	76	7.14	2.76	2.59	1.16	18.5	7.1	1.36	.304	4.56	103	4.17	100	9.48	12.3
18	Javier Vazquez J. Vazquez	2,434	391	151	137	.524	385	4.04	2,284	25	7	0	2513.0	1,129	1,212	322	643	73	4	52	10,504	72	8.18	2.30	3.55	1.15	21.7	6.1	1.22	.294	4.34	91	3.77	86	8.72	179
19	Cole Hamels C. Hamels	2,424	423	163	122	.572	422	3.43	2,560	17	7	0	2698.0	1,027	1,103	310	767	100	0	43	11,115	57	8.54	2.56	3.34	1.03	23.0	6.9	1.18	.287	3.68	82	3.68	88	8.09	151.3
20	Barry Zito B. Zito	2,381	433	165	143	.536	421	4.04	1,885	12	5	0	2576.2	1,157	1,254	282	1,064	97	9	52	11,001	50	6.58	3.72	1.77	0.98	17.1	9.7	1.34	.274	4.38	97	4.38	104	8.32	-43.1
21	Kevin Millwood K. Millwood	2,372	375	129	134	.490	373	4.26	1,673	17	5	0	2266.2	1,073	1,165	253	707	65	0	40	9,735	55	6.64	2.81	2.37	1.00	17.2	7.3	1.36	.301	4.63	97	4.07	93	9.42	78.1
22	Andy Pettitte A. Pettitte	2,361	366	175	107	.621	363	3.82	1,739	12	3	0	2271.2	963	1,080	203	655	39	1	33	9,631	40	6.89	2.60	2.65	0.80	18.1	6.8	1.33	.309	4.28	86	3.63	82	9.35	201.4
23	Dan Haren D. Haren	2,357	391	153	131	.539	380	3.75	2,013	16	6	1	2419.2	1,009	1,105	305	500	67	4	39	10,022	98	7.49	1.86	4.03	1.13	20.1	5.0	1.18	.288	4.11	92	3.77	92	8.77	92.8
24	Jeff Suppan J. Suppan	2,332	360	120	121	.498	342	4.58	1,137	11	4	0	2097.2	1,068	1,173	277	733	85	10	51	9,197	74	4.88	3.14	1.55	1.19	12.4	8.0	1.46	.295	5.03	104	4.88	111	10.01	-109
25	Ervin Santana E. Santana	2,326	387	149	127	.540	384	4.09	1,926	21	11	0	2421.1	1,101	1,186	322	754	102	1	34	10,205	97	7.16	2.80	2.55	1.20	18.9	7.4	1.27	.282	4.41	99	4.30	104	8.65	-42.3