5 teams are tied for the most home runs in a loss, with 7 home runs. The first three are the Los Angeles Angels on August 4, 2022, the Minnesota Twins on July 28, 2021 and the Toronto Blue Jays on August 12, 2020.

Interpreted as:

MLB most home runs in a regular-season loss

	TEAM	HR	L	DATE	TM		OPP	RESULT	W	L%	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Angels	7	1	8/4/2022	LAA	vs	OAK	L 7-8	0	1.000	35	7	9	1	0	7	2	1	9	0	0	38	31	8	0	0	0	1	.257	.316	.886	1.202
2	Twins	7	1	7/28/2021	MIN	vs	DET	L 14-17	0	1.000	43	14	16	1	0	14	7	1	8	0	0	51	38	8	0	0	0	0	.372	.471	.884	1.354
3	Blue Jays	7	1	8/12/2020	TOR	vs	MIA	L 11-14	0	1.000	46	11	18	2	0	11	4	0	12	3	0	50	41	9	0	0	0	0	.391	.440	.891	1.331
4	White Sox	7	1	6/25/2016	CWS	vs	TOR	L 8-10	0	1.000	39	8	12	1	0	8	1	0	11	1	0	40	34	8	0	0	0	1	.308	.325	.872	1.197
5	Tigers	7	1	8/8/2004	DET	vs	BOS	L 9-11	0	1.000	37	9	11	1	0	9	1	0	3	0	0	38	33	8	0	0	0	1	.297	.316	.892	1.208
6	Tigers	7	1	5/28/1995	DET	vs	CWS	L 12-14	0	1.000	44	12	17	3	0	12	8	2	11	5	1	54	41	10	0	0	1	1	.386	.500	.932	1.432
7	Nationals	6	1	9/26/2025	WSH	vs	CWS	L 9-10	0	1.000	38	9	13	1	0	9	1	0	11	0	0	39	32	7	0	0	0	2	.342	.359	.842	1.201
8	Orioles	6	1	6/19/2021	BAL	vs	TOR	L 7-10	0	1.000	36	7	9	0	0	7	2	1	12	0	0	39	27	6	0	0	0	0	.250	.308	.750	1.058
9	Reds	6	1	4/22/2021	CIN	vs	ARI	L 11-14	0	1.000	44	11	13	1	0	11	4	0	13	0	0	48	32	7	0	0	0	0	.295	.354	.727	1.081
10	Yankees	6	1	9/10/2019	NYY	@	DET	L 11-12	0	1.000	38	11	11	1	1	11	2	0	9	1	0	40	32	8	0	0	0	0	.289	.325	.842	1.167
11	Twins	6	1	8/31/2019	MIN	@	DET	L 7-10	0	1.000	37	7	10	1	0	7	4	0	17	0	0	41	29	7	0	0	0	1	.270	.341	.784	1.125
12	Diamondbacks	6	1	8/16/2019	ARI	vs	SFG	L 9-10	0	1.000	46	9	13	2	0	9	3	0	9	0	0	49	33	8	0	0	0	0	.283	.327	.717	1.044
13	Braves	6	1	8/15/2019	ATL	vs	NYM	L 8-10	0	1.000	37	8	11	0	0	8	5	0	8	0	0	42	29	6	0	0	0	2	.297	.381	.784	1.165
14	White Sox	6	1	7/26/2018	CWS	@	LAA	L 8-12	0	1.000	35	8	9	0	0	8	5	0	12	0	0	40	27	6	0	0	0	1	.257	.350	.771	1.121
15	Cubs	6	1	8/17/2017	CHC	vs	CIN	L 10-13	0	1.000	38	10	13	3	1	10	2	1	10	0	0	42	36	10	0	1	0	0	.342	.381	.947	1.328
16	Yankees	6	1	9/24/2010	NYY	vs	BOS	L 8-10	0	1.000	37	8	10	0	0	8	4	0	8	0	0	41	28	6	0	0	0	1	.270	.341	.757	1.098
17	Blue Jays	6	1	5/21/2010	TOR	@	ARI	L 6-8	0	1.000	38	6	12	1	0	6	0	0	9	0	0	38	31	7	0	0	0	1	.316	.316	.816	1.132
18	Orioles	6	1	8/28/2007	BAL	vs	TBD	L 8-15	0	1.000	39	8	13	0	1	8	1	0	7	2	1	40	33	7	0	0	0	0	.333	.350	.846	1.196
19	Tigers	6	1	7/2/2002	DET	@	CWS	L 9-17	0	1.000	38	9	13	2	1	9	2	0	6	0	0	40	35	9	0	0	0	1	.342	.375	.921	1.296
20	Yankees	6	1	7/10/1999	NYY	@	NYM	L 8-9	0	1.000	36	8	11	1	0	8	8	0	8	1	2	44	30	7	0	0	1	0	.306	.432	.833	1.265
21	Dodgers	6	1	6/30/1996	LAD	@	COL	L 15-16	0	1.000	44	15	18	2	1	15	6	0	12	2	0	51	40	9	0	1	0	0	.409	.471	.909	1.380
22	Athletics	6	1	8/3/1991	OAK	vs	MIN	L 6-8	0	1.000	37	6	10	2	0	6	4	0	8	0	0	41	30	8	0	0	0	0	.270	.341	.811	1.152
23	Angels	6	1	4/23/1985	CAL	vs	OAK	L 9-14	0	1.000	38	9	11	1	0	7	4	0	6	1	0	42	30	7	0	0	0	1	.289	.357	.789	1.147
24	Red Sox	6	1	5/31/1980	BOS	vs	MIL	L 8-19	0	1.000	35	8	12	1	0	8	4	0	3	0	0	39	31	7	0	0	0	4	.343	.410	.886	1.296
25	Cubs	6	1	5/17/1979	CHC	vs	PHI	L 22-23	0	1.000	56	22	26	3	1	22	3	0	4	0	0	59	49	10	0	0	0	2	.464	.492	.875	1.367