Johan Santana and Chien-Ming Wang were tied for winning the most games in 2006, with 19 wins.

	NAME	W	SEASON	TM	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Johan Santana J. Santana	19	2006	MIN	6	.760	34	34	2.77	245	1	0	0	233.2	186	72	79	24	47	4	0	0	923	4	9.44	1.81	5.21	0.92	26.5	5.1	1.00	.269	3.04	62	3.03	69	7.16	35.7
2	Chien-Ming Wang C. Wang	19	2006	NYY	6	.760	34	33	3.63	76	2	1	1	218.0	233	88	92	12	52	2	1	4	900	6	3.14	2.15	1.46	0.50	8.4	5.8	1.31	.292	3.80	80	3.90	86	9.62	14.9
3	Jon Garland J. Garland	18	2006	CWS	7	.720	33	32	4.51	112	1	1	0	211.1	247	106	112	26	41	6	0	4	900	4	4.77	1.75	2.73	1.11	12.4	4.6	1.36	.309	4.77	95	4.35	92	10.52	9.2
4	Freddy Garcia F. Garcia	17	2006	CWS	9	.654	33	33	4.53	135	1	0	0	216.1	228	109	116	32	48	7	0	3	917	4	5.62	2.00	2.81	1.33	14.7	5.2	1.28	.282	4.83	96	4.58	97	9.49	4.2
5	Randy Johnson R. Johnson	17	2006	NYY	11	.607	33	33	5.00	172	2	0	0	205.0	194	114	125	28	60	10	0	1	860	3	7.55	2.63	2.87	1.23	20.0	7.0	1.24	.281	5.49	110	4.26	94	8.52	5.8
6	Kenny Rogers K. Rogers	17	2006	DET	8	.680	34	33	3.84	99	0	0	0	204.0	195	87	97	23	62	9	1	2	849	5	4.37	2.74	1.60	1.01	11.7	7.3	1.26	.262	4.28	84	4.68	104	8.60	-3.7
7	Justin Verlander J. Verlander	17	2006	DET	9	.654	30	30	3.63	124	1	1	0	186.0	187	75	78	21	60	6	0	1	776	5	6.00	2.90	2.07	1.02	16.0	7.7	1.33	.294	3.77	80	4.34	96	9.05	3.6
8	Josh Beckett J. Beckett	16	2006	BOS	11	.593	33	33	5.01	158	0	0	0	204.2	191	114	120	36	74	10	0	1	869	11	6.95	3.25	2.14	1.58	18.2	8.5	1.29	.262	5.28	107	5.11	116	8.40	-16.2
9	Joe Blanton J. Blanton	16	2006	OAK	12	.571	32	31	4.82	107	1	1	0	194.1	241	104	111	17	58	5	0	4	856	3	4.96	2.69	1.84	0.79	12.5	6.8	1.54	.335	5.14	108	4.15	92	11.16	7.9
10	Roy Halladay R. Halladay	16	2006	TOR	5	.762	32	32	3.19	132	4	0	0	220.0	208	78	82	19	34	5	0	5	876	3	5.40	1.39	3.88	0.78	15.1	3.9	1.10	.276	3.35	69	3.59	79	8.51	23.5
11	Aaron Harang A. Harang	16	2006	CIN	11	.593	36	35	3.76	216	6	2	0	234.1	242	98	109	28	56	8	0	8	993	6	8.30	2.15	3.86	1.08	21.8	5.6	1.27	.312	4.19	82	3.67	79	9.29	25.4
12	Derek Lowe D. Lowe	16	2006	LAD	8	.667	35	34	3.63	123	1	0	0	218.0	221	88	97	14	55	5	1	2	913	3	5.08	2.27	2.24	0.58	13.5	6.0	1.27	.289	4.00	83	3.67	82	9.12	19.7
13	Kevin Millwood K. Millwood	16	2006	TEX	12	.571	34	34	4.52	157	2	0	0	215.0	228	108	114	23	53	4	0	4	907	6	6.57	2.22	2.96	0.96	17.3	5.8	1.31	.306	4.77	95	3.86	84	9.54	17.5
14	Brad Penny B. Penny	16	2006	LAD	9	.640	34	33	4.33	148	0	0	0	189.0	206	91	94	19	54	9	0	4	813	6	7.05	2.57	2.74	0.90	18.2	6.6	1.38	.321	4.48	99	3.88	87	9.81	12.6
15	Ervin Santana E. Santana	16	2006	LAA	8	.667	33	33	4.28	141	0	0	0	204.0	181	97	106	21	70	11	0	2	846	10	6.22	3.09	2.01	0.93	16.7	8.3	1.23	.265	4.68	95	4.29	96	7.99	4.1
16	John Smoltz J. Smoltz	16	2006	ATL	9	.640	35	35	3.49	211	3	1	0	232.0	221	90	93	23	55	9	0	4	960	5	8.19	2.13	3.84	0.89	22.0	5.7	1.19	.299	3.61	78	3.44	77	8.57	27
17	Brandon Webb B. Webb	16	2006	ARI	8	.667	33	33	3.10	178	5	3	0	235.0	216	81	91	15	50	6	0	4	950	5	6.82	1.91	3.56	0.57	18.7	5.3	1.13	.287	3.49	66	3.17	68	8.27	38.1
18	Carlos Zambrano C. Zambrano	16	2006	CHC	7	.696	33	33	3.41	210	0	0	0	214.0	162	81	91	20	115	9	0	4	917	9	8.83	4.84	1.83	0.84	22.9	12.5	1.29	.252	3.83	73	4.13	89	6.81	11.5
19	Barry Zito B. Zito	16	2006	OAK	10	.615	34	34	3.83	151	0	0	0	221.0	211	94	99	27	99	13	0	5	945	4	6.15	4.03	1.53	1.10	16.0	10.5	1.40	.281	4.03	86	4.88	108	8.59	-9
20	Erik Bedard E. Bedard	15	2006	BAL	11	.577	33	33	3.76	171	0	0	0	196.1	196	82	92	16	69	5	0	0	844	6	7.84	3.16	2.48	0.73	20.3	8.2	1.35	.309	4.22	82	3.59	77	8.98	22.7
21	Chris Carpenter C. Carpenter	15	2006	STL	8	.652	32	32	3.09	184	5	3	0	221.2	194	76	81	21	43	10	0	3	896	3	7.47	1.75	4.28	0.85	20.5	4.8	1.07	.271	3.29	71	3.43	77	7.88	25.1
22	Tom Glavine T. Glavine	15	2006	NYM	7	.682	32	32	3.82	131	0	0	0	198.0	202	84	94	22	62	6	0	7	842	1	5.95	2.82	2.11	1.00	15.6	7.4	1.33	.290	4.27	88	4.29	96	9.18	4.1
23	Ted Lilly T. Lilly	15	2006	TOR	13	.536	32	32	4.31	160	0	0	0	181.2	179	87	98	28	81	4	0	6	797	7	7.93	4.01	1.98	1.39	20.1	10.2	1.43	.288	4.86	94	4.79	105	8.87	-4.4
24	Greg Maddux G. Maddux	15	2006	TOT	14	.517	34	34	4.20	117	0	0	0	210.0	219	98	109	20	37	0	0	7	862	0	5.01	1.59	3.16	0.86	13.6	4.3	1.22	.289	4.67	92	3.79	83	9.39	18
25	Mike Mussina M. Mussina	15	2006	NYY	7	.682	32	32	3.51	172	1	0	0	197.1	184	77	88	22	35	5	0	1	804	3	7.84	1.60	4.91	1.00	21.4	4.4	1.11	.284	4.01	77	3.45	77	8.39	23.3